BDBM272583 2-amino-N-(1-(4-chloro- 7-ethoxy-1-(2- hydroxyethyl)-1H- indazol-6- yl)ethyl)pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10065963, Example 6

SMILES CCOc1c(cc(Cl)c2cnn(CCO)c12)C(C)NC(=O)c1c(N)nn2cccnc12

InChI Key InChIKey=WPJKOTCWDKMOTM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272583   

LigandPNGBDBM272583(2-amino-N-(1-(4-chloro- 7-ethoxy-1-(2- hydroxyethy...)
Affinity DataIC50: 100nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
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LigandPNGBDBM272583(2-amino-N-(1-(4-chloro- 7-ethoxy-1-(2- hydroxyethy...)
Affinity DataIC50: 100nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

LigandPNGBDBM272583(2-amino-N-(1-(4-chloro- 7-ethoxy-1-(2- hydroxyethy...)
Affinity DataIC50: 500nMAssay Description:To measure the Phosphorylated Ribosomal Protein S6 (RPS6) in cell lysates, THP-1 cells (Human Acute Monocytic Leukemia) are purchased from ATCC (Mana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent