BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1578554 CC(C)(C)OC(=O)NC12CC3CC(CC(N)(C3)C1)C2 789046 tert-butyl (3-aminoadamantan-1-yl)carbamate::US20250353833, Compound 4 Dipeptidyl peptidase 4 Homo sapiens 10.00 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789046&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 84102059 523966660 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578555 CC(C)(C)OC(=O)NC12CC3CC(CC(N)(C3)C1)C2 789046 tert-butyl (3-aminoadamantan-1-yl)carbamate::US20250353833, Compound 4 Dipeptidyl peptidase 8 Homo sapiens 2200 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789046&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 84102059 523966660 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578556 CC(C)(C)OC(=O)NC12CC3CC(CC(N)(C3)C1)C2 789046 tert-butyl (3-aminoadamantan-1-yl)carbamate::US20250353833, Compound 4 Dipeptidyl peptidase 9 Homo sapiens 230 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789046&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 84102059 523966660 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578557 CC(C)(C)OC(=O)NC12CC3CC(CC(N)(C3)C1)C2 789046 tert-butyl (3-aminoadamantan-1-yl)carbamate::US20250353833, Compound 4 Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789046&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 84102059 523966660 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578558 CC(C)(C)OC(=O)NC12CC3CC(CC(N)(C3)C1)C2 789046 tert-butyl (3-aminoadamantan-1-yl)carbamate::US20250353833, Compound 4 Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789046&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 84102059 523966660 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578559 CC(C)(C)OC(=O)NC12CC3CC(CC(N)(C3)C1)C2 789046 tert-butyl (3-aminoadamantan-1-yl)carbamate::US20250353833, Compound 4 Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789046&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 84102059 523966660 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578560 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789047 (S)-1-((-3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5a Dipeptidyl peptidase 4 Homo sapiens 4.80 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789047&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969861 523966661 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578561 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789047 (S)-1-((-3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5a Dipeptidyl peptidase 8 Homo sapiens 1320 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789047&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969861 523966661 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578562 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789047 (S)-1-((-3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5a Dipeptidyl peptidase 9 Homo sapiens 130 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789047&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969861 523966661 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578563 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789047 (S)-1-((-3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5a Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789047&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969861 523966661 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578564 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789047 (S)-1-((-3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5a Prolyl endopeptidase FAP Homo sapiens 4000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789047&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969861 523966661 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578565 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789047 (S)-1-((-3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5a Presequence protease, mitochondrial Homo sapiens 4300 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789047&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969861 523966661 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578566 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789048 (S)-1-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5b Dipeptidyl peptidase 4 Homo sapiens 5.00 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789048&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969772 523966662 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578567 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789048 (S)-1-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5b Dipeptidyl peptidase 8 Homo sapiens 540 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789048&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969772 523966662 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578568 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789048 (S)-1-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5b Dipeptidyl peptidase 9 Homo sapiens 52.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789048&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969772 523966662 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578569 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789048 (S)-1-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5b Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789048&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969772 523966662 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578570 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789048 (S)-1-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5b Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789048&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969772 523966662 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578571 N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789048 (S)-1-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5b Presequence protease, mitochondrial Homo sapiens 2200 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789048&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969772 523966662 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578572 CCCCOC12CC3CC(CC(NCC(=O)N4CCC[C@H]4C#N)(C3)C1)C2 789049 (2S)-1-((-3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5c Dipeptidyl peptidase 4 Homo sapiens 12.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789049&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969784 523966663 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578573 CCCCOC12CC3CC(CC(NCC(=O)N4CCC[C@H]4C#N)(C3)C1)C2 789049 (2S)-1-((-3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5c Dipeptidyl peptidase 8 Homo sapiens 1250 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789049&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969784 523966663 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578574 CCCCOC12CC3CC(CC(NCC(=O)N4CCC[C@H]4C#N)(C3)C1)C2 789049 (2S)-1-((-3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5c Dipeptidyl peptidase 9 Homo sapiens 150 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789049&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969784 523966663 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578575 CCCCOC12CC3CC(CC(NCC(=O)N4CCC[C@H]4C#N)(C3)C1)C2 789049 (2S)-1-((-3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5c Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789049&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969784 523966663 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578576 CCCCOC12CC3CC(CC(NCC(=O)N4CCC[C@H]4C#N)(C3)C1)C2 789049 (2S)-1-((-3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5c Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789049&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969784 523966663 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578577 CCCCOC12CC3CC(CC(NCC(=O)N4CCC[C@H]4C#N)(C3)C1)C2 789049 (2S)-1-((-3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5c Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789049&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969784 523966663 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578578 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789051 (2S,4S)-4-azido-1-((-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5d Dipeptidyl peptidase 4 Homo sapiens 32.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789051&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969726 523966665 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578579 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789051 (2S,4S)-4-azido-1-((-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5d Dipeptidyl peptidase 8 Homo sapiens 150 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789051&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969726 523966665 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578580 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789051 (2S,4S)-4-azido-1-((-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5d Dipeptidyl peptidase 9 Homo sapiens 16.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789051&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969726 523966665 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578581 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789051 (2S,4S)-4-azido-1-((-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5d Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789051&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969726 523966665 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578582 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789051 (2S,4S)-4-azido-1-((-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5d Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789051&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969726 523966665 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578583 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789051 (2S,4S)-4-azido-1-((-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5d Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789051&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969726 523966665 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578584 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789052 (2S,4S)-4-azido-1-((3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5e Dipeptidyl peptidase 4 Homo sapiens 17.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789052&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 177779207 523966666 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578585 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789052 (2S,4S)-4-azido-1-((3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5e Dipeptidyl peptidase 8 Homo sapiens 60.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789052&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177779207 523966666 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578586 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789052 (2S,4S)-4-azido-1-((3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5e Dipeptidyl peptidase 9 Homo sapiens 10.00 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789052&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 177779207 523966666 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578587 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789052 (2S,4S)-4-azido-1-((3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5e Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789052&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 177779207 523966666 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578588 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789052 (2S,4S)-4-azido-1-((3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5e Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789052&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 177779207 523966666 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578589 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789052 (2S,4S)-4-azido-1-((3-(benzyloxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5e Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789052&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 177779207 523966666 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578590 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789053 (2S,4S)-4-azido-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5f Dipeptidyl peptidase 4 Homo sapiens 24.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789053&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969805 523966667 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578591 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789053 (2S,4S)-4-azido-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5f Dipeptidyl peptidase 8 Homo sapiens 41.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789053&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969805 523966667 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578592 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789053 (2S,4S)-4-azido-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5f Dipeptidyl peptidase 9 Homo sapiens 6.00 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789053&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969805 523966667 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578593 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789053 (2S,4S)-4-azido-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5f Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789053&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969805 523966667 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578594 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789053 (2S,4S)-4-azido-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5f Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789053&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969805 523966667 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578595 N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789053 (2S,4S)-4-azido-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5f Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789053&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969805 523966667 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578596 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@@H](N=[N+]=[N-])C[C@H]4C#N)(C3)C1)C2 789054 (2S,4S)-4-azido-1-((3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5g Dipeptidyl peptidase 4 Homo sapiens 13000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789054&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969746 523966668 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578597 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@@H](N=[N+]=[N-])C[C@H]4C#N)(C3)C1)C2 789054 (2S,4S)-4-azido-1-((3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5g Dipeptidyl peptidase 8 Homo sapiens 270 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789054&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969746 523966668 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578598 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@@H](N=[N+]=[N-])C[C@H]4C#N)(C3)C1)C2 789054 (2S,4S)-4-azido-1-((3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5g Dipeptidyl peptidase 9 Homo sapiens 35.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789054&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969746 523966668 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578599 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@@H](N=[N+]=[N-])C[C@H]4C#N)(C3)C1)C2 789054 (2S,4S)-4-azido-1-((3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5g Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789054&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969746 523966668 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578600 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@@H](N=[N+]=[N-])C[C@H]4C#N)(C3)C1)C2 789054 (2S,4S)-4-azido-1-((3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5g Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789054&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969746 523966668 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578601 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@@H](N=[N+]=[N-])C[C@H]4C#N)(C3)C1)C2 789054 (2S,4S)-4-azido-1-((3-butoxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile::US20250353833, Compound 5g Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789054&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969746 523966668 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578602 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(CC(O)(C4)C2)C3)C1 789055 US20250353833, Compound 5h Dipeptidyl peptidase 4 Homo sapiens 230 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789055&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969863 523966669 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578603 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(CC(O)(C4)C2)C3)C1 789055 US20250353833, Compound 5h Dipeptidyl peptidase 8 Homo sapiens 1000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789055&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969863 523966669 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578604 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(CC(O)(C4)C2)C3)C1 789055 US20250353833, Compound 5h Dipeptidyl peptidase 9 Homo sapiens 260 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789055&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969863 523966669 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578605 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(CC(O)(C4)C2)C3)C1 789055 US20250353833, Compound 5h Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789055&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969863 523966669 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578606 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(CC(O)(C4)C2)C3)C1 789055 US20250353833, Compound 5h Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789055&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969863 523966669 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578607 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(CC(O)(C4)C2)C3)C1 789055 US20250353833, Compound 5h Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789055&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969863 523966669 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578608 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccccc2)(C4)C3)C1 789056 (S)-1-((3-(benzyloxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5i Dipeptidyl peptidase 4 Homo sapiens 280 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789056&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969737 523966670 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578609 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccccc2)(C4)C3)C1 789056 (S)-1-((3-(benzyloxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5i Dipeptidyl peptidase 8 Homo sapiens 340 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789056&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969737 523966670 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578610 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccccc2)(C4)C3)C1 789056 (S)-1-((3-(benzyloxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5i Dipeptidyl peptidase 9 Homo sapiens 120 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789056&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969737 523966670 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578611 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccccc2)(C4)C3)C1 789056 (S)-1-((3-(benzyloxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5i Dipeptidyl peptidase 2 Homo sapiens 1270 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789056&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969737 523966670 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578612 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccccc2)(C4)C3)C1 789056 (S)-1-((3-(benzyloxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5i Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789056&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969737 523966670 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578613 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccccc2)(C4)C3)C1 789056 (S)-1-((3-(benzyloxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5i Presequence protease, mitochondrial Homo sapiens 8920 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789056&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969737 523966670 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578614 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccc(F)cc2F)(C4)C3)C1 789057 (2S)-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5j Dipeptidyl peptidase 4 Homo sapiens 410 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789057&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969716 523966671 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578615 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccc(F)cc2F)(C4)C3)C1 789057 (2S)-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5j Dipeptidyl peptidase 8 Homo sapiens 370 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789057&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969716 523966671 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578616 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccc(F)cc2F)(C4)C3)C1 789057 (2S)-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5j Dipeptidyl peptidase 9 Homo sapiens 130 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789057&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969716 523966671 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578617 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccc(F)cc2F)(C4)C3)C1 789057 (2S)-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5j Dipeptidyl peptidase 2 Homo sapiens 1100 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789057&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969716 523966671 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578618 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccc(F)cc2F)(C4)C3)C1 789057 (2S)-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5j Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789057&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969716 523966671 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578619 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCc2ccc(F)cc2F)(C4)C3)C1 789057 (2S)-1-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5j Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789057&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969716 523966671 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578620 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCCCC)(C4)C3)C1 789058 (S)-1-((-3-butoxyadamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5k Dipeptidyl peptidase 4 Homo sapiens 320 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789058&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969796 523966672 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578621 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCCCC)(C4)C3)C1 789058 (S)-1-((-3-butoxyadamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5k Dipeptidyl peptidase 8 Homo sapiens 530 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789058&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969796 523966672 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578622 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCCCC)(C4)C3)C1 789058 (S)-1-((-3-butoxyadamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5k Dipeptidyl peptidase 9 Homo sapiens 210 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789058&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969796 523966672 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578623 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCCCC)(C4)C3)C1 789058 (S)-1-((-3-butoxyadamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5k Dipeptidyl peptidase 2 Homo sapiens 1200 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789058&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969796 523966672 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578624 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCCCC)(C4)C3)C1 789058 (S)-1-((-3-butoxyadamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5k Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789058&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969796 523966672 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578625 C=C1C[C@@H](C#N)N(C(=O)CNC23CC4CC(C2)CC(OCCCC)(C4)C3)C1 789058 (S)-1-((-3-butoxyadamantan-1-yl)glycyl)-4-methylenepyrrolidine-2-carbonitrile::US20250353833, Compound 5k Presequence protease, mitochondrial Homo sapiens 2200 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789058&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969796 523966672 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578626 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789059 US20250353833, Compound 5l Dipeptidyl peptidase 4 Homo sapiens 180 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789059&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969798 523966673 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578627 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789059 US20250353833, Compound 5l Dipeptidyl peptidase 8 Homo sapiens 21400 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789059&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969798 523966673 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578628 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789059 US20250353833, Compound 5l Dipeptidyl peptidase 9 Homo sapiens 1220 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789059&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969798 523966673 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578629 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789059 US20250353833, Compound 5l Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789059&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969798 523966673 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578630 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789059 US20250353833, Compound 5l Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789059&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969798 523966673 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578631 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 789059 US20250353833, Compound 5l Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789059&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969798 523966673 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578632 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789060 (1R,2S,5S)-3-((-3-(benzyloxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5m Dipeptidyl peptidase 4 Homo sapiens 100.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789060&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969850 523966674 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578633 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789060 (1R,2S,5S)-3-((-3-(benzyloxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5m Dipeptidyl peptidase 8 Homo sapiens 5900 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789060&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969850 523966674 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578634 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789060 (1R,2S,5S)-3-((-3-(benzyloxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5m Dipeptidyl peptidase 9 Homo sapiens 670 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789060&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969850 523966674 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578635 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789060 (1R,2S,5S)-3-((-3-(benzyloxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5m Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789060&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969850 523966674 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578636 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789060 (1R,2S,5S)-3-((-3-(benzyloxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5m Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789060&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969850 523966674 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578637 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2 789060 (1R,2S,5S)-3-((-3-(benzyloxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5m Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789060&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969850 523966674 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578638 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789061 (1R,2S,5S)-3-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5n Dipeptidyl peptidase 4 Homo sapiens 200 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789061&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969887 523966675 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578639 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789061 (1R,2S,5S)-3-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5n Dipeptidyl peptidase 8 Homo sapiens 2000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789061&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969887 523966675 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578640 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789061 (1R,2S,5S)-3-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5n Dipeptidyl peptidase 9 Homo sapiens 620 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789061&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969887 523966675 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578641 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789061 (1R,2S,5S)-3-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5n Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789061&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969887 523966675 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578642 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789061 (1R,2S,5S)-3-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5n Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789061&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969887 523966675 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578643 N#C[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2 789061 (1R,2S,5S)-3-((3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5n Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789061&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969887 523966675 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578644 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@H]5C[C@H]5[C@H]4C#N)(C3)C1)C2 789062 (1R,2S,5S)-3-((-3-butoxyadamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5o Dipeptidyl peptidase 4 Homo sapiens 150 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789062&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969865 523966676 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578645 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@H]5C[C@H]5[C@H]4C#N)(C3)C1)C2 789062 (1R,2S,5S)-3-((-3-butoxyadamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5o Dipeptidyl peptidase 8 Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789062&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969865 523966676 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578646 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@H]5C[C@H]5[C@H]4C#N)(C3)C1)C2 789062 (1R,2S,5S)-3-((-3-butoxyadamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5o Dipeptidyl peptidase 9 Homo sapiens 990 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789062&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969865 523966676 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578647 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@H]5C[C@H]5[C@H]4C#N)(C3)C1)C2 789062 (1R,2S,5S)-3-((-3-butoxyadamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5o Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789062&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969865 523966676 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578648 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@H]5C[C@H]5[C@H]4C#N)(C3)C1)C2 789062 (1R,2S,5S)-3-((-3-butoxyadamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5o Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789062&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969865 523966676 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578649 CCCCOC12CC3CC(CC(NCC(=O)N4C[C@H]5C[C@H]5[C@H]4C#N)(C3)C1)C2 789062 (1R,2S,5S)-3-((-3-butoxyadamantan-1-yl)glycyl)-3-azabicyclo[3.1.0]hexane-2-carbonitrile::US20250353833, Compound 5o Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789062&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969865 523966676 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578650 O=C(CNC12CC3CC(CC(O)(C3)C1)C2)N1Cc2ccccc2C1 789063 2-((-3-hydroxyadamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5p Dipeptidyl peptidase 4 Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789063&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969824 523966677 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578651 O=C(CNC12CC3CC(CC(O)(C3)C1)C2)N1Cc2ccccc2C1 789063 2-((-3-hydroxyadamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5p Dipeptidyl peptidase 8 Homo sapiens 17700 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789063&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969824 523966677 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578652 O=C(CNC12CC3CC(CC(O)(C3)C1)C2)N1Cc2ccccc2C1 789063 2-((-3-hydroxyadamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5p Dipeptidyl peptidase 9 Homo sapiens 4100 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789063&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969824 523966677 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578653 O=C(CNC12CC3CC(CC(O)(C3)C1)C2)N1Cc2ccccc2C1 789063 2-((-3-hydroxyadamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5p Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789063&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969824 523966677 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578654 O=C(CNC12CC3CC(CC(O)(C3)C1)C2)N1Cc2ccccc2C1 789063 2-((-3-hydroxyadamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5p Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789063&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969824 523966677 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578655 O=C(CNC12CC3CC(CC(O)(C3)C1)C2)N1Cc2ccccc2C1 789063 2-((-3-hydroxyadamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5p Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789063&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969824 523966677 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578656 O=C(CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2)N1Cc2ccccc2C1 789064 2-((3-(benzyloxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5q Dipeptidyl peptidase 4 Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789064&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969836 523966678 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578657 O=C(CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2)N1Cc2ccccc2C1 789064 2-((3-(benzyloxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5q Dipeptidyl peptidase 8 Homo sapiens 6900 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789064&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969836 523966678 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578658 O=C(CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2)N1Cc2ccccc2C1 789064 2-((3-(benzyloxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5q Dipeptidyl peptidase 9 Homo sapiens 1200 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789064&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969836 523966678 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578659 O=C(CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2)N1Cc2ccccc2C1 789064 2-((3-(benzyloxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5q Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789064&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969836 523966678 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578660 O=C(CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2)N1Cc2ccccc2C1 789064 2-((3-(benzyloxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5q Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789064&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969836 523966678 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578661 O=C(CNC12CC3CC(C1)CC(OCc1ccccc1)(C3)C2)N1Cc2ccccc2C1 789064 2-((3-(benzyloxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5q Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789064&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969836 523966678 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578662 O=C(CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2)N1Cc2ccccc2C1 789065 2-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5r Dipeptidyl peptidase 4 Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789065&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969835 523966679 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578663 O=C(CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2)N1Cc2ccccc2C1 789065 2-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5r Dipeptidyl peptidase 8 Homo sapiens 1540 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789065&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969835 523966679 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578664 O=C(CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2)N1Cc2ccccc2C1 789065 2-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5r Dipeptidyl peptidase 9 Homo sapiens 380 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789065&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969835 523966679 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578665 O=C(CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2)N1Cc2ccccc2C1 789065 2-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5r Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789065&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969835 523966679 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578666 O=C(CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2)N1Cc2ccccc2C1 789065 2-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5r Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789065&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969835 523966679 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578667 O=C(CNC12CC3CC(C1)CC(OCc1ccc(F)cc1F)(C3)C2)N1Cc2ccccc2C1 789065 2-((-3-((2,4-difluorobenzyl)oxy)adamantan-1-yl)amino)-1-(isoindolin-2-yl)ethan-1-one::US20250353833, Compound 5r Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789065&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969835 523966679 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578668 CCCCOC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:4:5:8:12.11.10,THB:13:5:8:12.11.10,13:11:8:27.6.5,14:11:8:27.6.5,6:7:10:27.5.13,6:5:8.7.12:10| 50629039 CHEMBL5440616::US20250353833, Compound 5s Dipeptidyl peptidase 4 Homo sapiens >10000 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629039&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 172471703 505047011 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578669 CCCCOC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:4:5:8:12.11.10,THB:13:5:8:12.11.10,13:11:8:27.6.5,14:11:8:27.6.5,6:7:10:27.5.13,6:5:8.7.12:10| 50629039 CHEMBL5440616::US20250353833, Compound 5s Dipeptidyl peptidase 8 Homo sapiens 3100 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629039&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172471703 505047011 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578670 CCCCOC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:4:5:8:12.11.10,THB:13:5:8:12.11.10,13:11:8:27.6.5,14:11:8:27.6.5,6:7:10:27.5.13,6:5:8.7.12:10| 50629039 CHEMBL5440616::US20250353833, Compound 5s Dipeptidyl peptidase 9 Homo sapiens 490 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629039&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 172471703 505047011 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578671 CCCCOC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:4:5:8:12.11.10,THB:13:5:8:12.11.10,13:11:8:27.6.5,14:11:8:27.6.5,6:7:10:27.5.13,6:5:8.7.12:10| 50629039 CHEMBL5440616::US20250353833, Compound 5s Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629039&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 172471703 505047011 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578672 CCCCOC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:4:5:8:12.11.10,THB:13:5:8:12.11.10,13:11:8:27.6.5,14:11:8:27.6.5,6:7:10:27.5.13,6:5:8.7.12:10| 50629039 CHEMBL5440616::US20250353833, Compound 5s Prolyl endopeptidase FAP Homo sapiens >10000 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629039&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 172471703 505047011 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578673 CCCCOC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:4:5:8:12.11.10,THB:13:5:8:12.11.10,13:11:8:27.6.5,14:11:8:27.6.5,6:7:10:27.5.13,6:5:8.7.12:10| 50629039 CHEMBL5440616::US20250353833, Compound 5s Presequence protease, mitochondrial Homo sapiens >10000 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629039&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 172471703 505047011 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578674 CC(C)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789067 1-(isoindolin-2-yl)-2-((-3-isopropoxyadamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5t Dipeptidyl peptidase 4 Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789067&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969916 523966681 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578675 CC(C)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789067 1-(isoindolin-2-yl)-2-((-3-isopropoxyadamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5t Dipeptidyl peptidase 8 Homo sapiens 4000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789067&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969916 523966681 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578676 CC(C)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789067 1-(isoindolin-2-yl)-2-((-3-isopropoxyadamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5t Dipeptidyl peptidase 9 Homo sapiens 610 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789067&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969916 523966681 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578677 CC(C)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789067 1-(isoindolin-2-yl)-2-((-3-isopropoxyadamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5t Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789067&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969916 523966681 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578678 CC(C)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789067 1-(isoindolin-2-yl)-2-((-3-isopropoxyadamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5t Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789067&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969916 523966681 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578679 CC(C)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789067 1-(isoindolin-2-yl)-2-((-3-isopropoxyadamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5t Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789067&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969916 523966681 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578680 CCCCCCCCOC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789068 1-(isoindolin-2-yl)-2-((-3-(octyloxy)adamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5u Dipeptidyl peptidase 4 Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1234&target=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789068&enzyme=Dipeptidyl+peptidase+4&column=ki&startPg=0&Increment=50&submit=Search 175969880 523966682 1 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP 9D56,9CAR,2BGR,2JID,3F8S,2QJR,3W2T,3VJM,3VJL,3VJK,1WCY,1J2E,1PFQ,8ZDX,2RIP,9JMM,9JMJ,5Y7K,5Y7J,5Y7H,4LKO,4L72,4JH0,4J3J,4DTC,4DSZ,4DSA,3OC0,3KWJ,3KWF,3H0C,3EIO,3BJM,2OQI,2OLE,2OGZ,2BUB,2BGN,2AJL,1W1I,1TKR,1TK3,1RWQ,1NU8,1NU6,1N1M,8WKU,4QZV,3SX4,3SWW,3Q0T,3NOX,2RGU,1R9N,9GOH,5KBY,4KR0,4G1F,3OPM,3O9V,3O95,3G0G,3G0D,3G0C,3G0B,3CCC,3CCB,1U8E,1R9M,3WQH,9V2P,9V2L,6B1O,6B1E,5T4H,5T4F,5T4E,5T4B,5ISM,5I7U,4PNZ,4N8E,4N8D,4A5S,3HAC,3HAB,3D4L,3C45,3C43,2QOE,2QKY,2P8S,2OPH,2IIV,2IIT,2HHA,2FJP,1X70,2ONC,8Z4T,5ZID,5J3J,2OQV,2OAG,2I78,2I03,2G63,2G5T,2G5P,3Q8W,9LBT,5LLS Dipeptidyl peptidase 4 DPP4_HUMAN P27487 Q53TN1 1578681 CCCCCCCCOC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789068 1-(isoindolin-2-yl)-2-((-3-(octyloxy)adamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5u Dipeptidyl peptidase 8 Homo sapiens 3300 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789068&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969880 523966682 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578682 CCCCCCCCOC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789068 1-(isoindolin-2-yl)-2-((-3-(octyloxy)adamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5u Dipeptidyl peptidase 9 Homo sapiens 500 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789068&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969880 523966682 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578683 CCCCCCCCOC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789068 1-(isoindolin-2-yl)-2-((-3-(octyloxy)adamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5u Dipeptidyl peptidase 2 Homo sapiens >5000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5468&target=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789068&enzyme=Dipeptidyl+peptidase+2&column=ki&startPg=0&Increment=50&submit=Search 175969880 523966682 1 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 4EBB,3N0T,3JYH Dipeptidyl peptidase 2 DPP2_HUMAN Q9UHL4 A8K7U7 Q5VSF1 Q969X4 1578684 CCCCCCCCOC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789068 1-(isoindolin-2-yl)-2-((-3-(octyloxy)adamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5u Prolyl endopeptidase FAP Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5699&target=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789068&enzyme=Prolyl+endopeptidase+FAP&column=ki&startPg=0&Increment=50&submit=Search 175969880 523966682 1 MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 9DVR,9DVQ,6Y0F,1Z68 Prolyl endopeptidase FAP SEPR_HUMAN Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4 1578685 CCCCCCCCOC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789068 1-(isoindolin-2-yl)-2-((-3-(octyloxy)adamantan-1-yl)amino)ethan-1-one::US20250353833, Compound 5u Presequence protease, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006502&target=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789068&enzyme=Presequence+protease%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 175969880 523966682 1 MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ 4RPU,4NGE,4L3T Presequence protease, mitochondrial PREP_HUMAN Q5JRX3 B3KMJ6 B4E0J8 C9JSL2 E7ES23 O95204 Q2M2G6 Q4VBR1 Q5JRW7 Q7L5Z7 Q9BSI6 Q9BVJ5 Q9UPP8 1578686 CCCCNC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1Cc2ccccc2C1 |TLB:4:5:8:11.12.13,10:5:8.9.11:13,THB:14:5:8:11.12.13,14:12:8:6.10.5,15:12:8:6.10.5,10:9:13:6.5.14| 50628991 CHEMBL5414516::US20250353833, Compound 25 Dipeptidyl peptidase 8 Homo sapiens >10000 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50628991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50628991&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172451192 505046963 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578687 CCCCNC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1Cc2ccccc2C1 |TLB:4:5:8:11.12.13,10:5:8.9.11:13,THB:14:5:8:11.12.13,14:12:8:6.10.5,15:12:8:6.10.5,10:9:13:6.5.14| 50628991 CHEMBL5414516::US20250353833, Compound 25 Dipeptidyl peptidase 8 Homo sapiens 477 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50628991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50628991&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172451192 505046963 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578688 N#Cc1ccc(CNC23CC4CC(CC(NCC(=O)N5Cc6ccccc6C5)(C4)C2)C3)cc1 789071 UAMC-000-3916::US20250353833, Compound 26 Dipeptidyl peptidase 8 Homo sapiens 672 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789071&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606027 523966685 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578689 N#Cc1ccc(CNC23CC4CC(CC(NCC(=O)N5Cc6ccccc6C5)(C4)C2)C3)cc1 789071 UAMC-000-3916::US20250353833, Compound 26 Dipeptidyl peptidase 8 Homo sapiens 50.6 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789071&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606027 523966685 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578690 O=C(CNC12CC3CC(C1)CC(NCc1ccc(-c4ccccc4)cc1)(C3)C2)N1Cc2ccccc2C1 789072 UAMC-000-3929::US20250353833, Compound 27 Dipeptidyl peptidase 8 Homo sapiens 1540 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789072&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606013 523966686 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578691 O=C(CNC12CC3CC(C1)CC(NCc1ccc(-c4ccccc4)cc1)(C3)C2)N1Cc2ccccc2C1 789072 UAMC-000-3929::US20250353833, Compound 27 Dipeptidyl peptidase 8 Homo sapiens 93.2 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789072&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606013 523966686 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578692 CC(C)(C)OC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:30.9.8,17:14:11:30.9.8,9:10:13:30.8.16,9:8:11.10.15:13| 50629021 CHEMBL5399745::US20250353833, Compound 28 Dipeptidyl peptidase 8 Homo sapiens 1140 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629021&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605922 505046993 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578693 CC(C)(C)OC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:30.9.8,17:14:11:30.9.8,9:10:13:30.8.16,9:8:11.10.15:13| 50629021 CHEMBL5399745::US20250353833, Compound 28 Dipeptidyl peptidase 8 Homo sapiens 4.73 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629021&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605922 505046993 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578694 OCCCCNC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:8:9:12:16.15.14,THB:17:9:12:16.15.14,17:15:12:31.10.9,18:15:12:31.10.9,10:11:14:31.9.17,10:9:12.11.16:14| 50629001 CHEMBL5431471::US20250353833, Compound 29 Dipeptidyl peptidase 8 Homo sapiens 2600 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629001&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605970 505046973 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578695 OCCCCNC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:8:9:12:16.15.14,THB:17:9:12:16.15.14,17:15:12:31.10.9,18:15:12:31.10.9,10:11:14:31.9.17,10:9:12.11.16:14| 50629001 CHEMBL5431471::US20250353833, Compound 29 Dipeptidyl peptidase 8 Homo sapiens 243 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629001&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605970 505046973 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578696 CC(C)(C)NC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:30.9.8,17:14:11:30.9.8,9:10:13:30.8.16,9:8:11.10.15:13| 50628998 CHEMBL5426720::US20250353833, Compound 30 Dipeptidyl peptidase 8 Homo sapiens 2590 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50628998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50628998&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172463062 505046970 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578697 CC(C)(C)NC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:30.9.8,17:14:11:30.9.8,9:10:13:30.8.16,9:8:11.10.15:13| 50628998 CHEMBL5426720::US20250353833, Compound 30 Dipeptidyl peptidase 8 Homo sapiens 1.98 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50628998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50628998&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172463062 505046970 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578698 CCC(C)(C)OC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789078 UAMC-000-4289::US20250353833, Compound 31 Dipeptidyl peptidase 8 Homo sapiens 4710 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789078&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184810 523966692 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578699 CCC(C)(C)OC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 789078 UAMC-000-4289::US20250353833, Compound 31 Dipeptidyl peptidase 8 Homo sapiens 378 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789078&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184810 523966692 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578700 Fc1ccc(cc1)C(NC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2)c1ccc(F)cc1 |TLB:11:12:15:19.18.17,THB:20:12:15:19.18.17,20:18:15:34.13.12,21:18:15:34.13.12,13:14:17:34.12.20,13:12:15.14.19:17| 50629014 CHEMBL5408720::US20250353833, Compound 32 Dipeptidyl peptidase 8 Homo sapiens 667 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629014&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605960 505046986 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578701 Fc1ccc(cc1)C(NC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2)c1ccc(F)cc1 |TLB:11:12:15:19.18.17,THB:20:12:15:19.18.17,20:18:15:34.13.12,21:18:15:34.13.12,13:14:17:34.12.20,13:12:15.14.19:17| 50629014 CHEMBL5408720::US20250353833, Compound 32 Dipeptidyl peptidase 8 Homo sapiens 7.66 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629014&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605960 505046986 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578702 O=C(NC(c1ccccc1)c1ccccc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:16:17:20:24.23.22,THB:25:17:20:24.23.22,25:23:20:39.18.17,26:23:20:39.18.17,18:19:22:39.17.25,18:17:20.19.24:22| 50629013 CHEMBL5406353::US20250353833, Compound 33 Dipeptidyl peptidase 8 Homo sapiens 175 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629013&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605907 505046985 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578703 O=C(NC(c1ccccc1)c1ccccc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:16:17:20:24.23.22,THB:25:17:20:24.23.22,25:23:20:39.18.17,26:23:20:39.18.17,18:19:22:39.17.25,18:17:20.19.24:22| 50629013 CHEMBL5406353::US20250353833, Compound 33 Dipeptidyl peptidase 8 Homo sapiens 2.52 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629013&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605907 505046985 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578704 O=C(NCCCC[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2)C(=O)O)OCc1ccccc1 789086 UAMC-000-4060::US20250353833, Compound 34 Dipeptidyl peptidase 8 Homo sapiens 9.06 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789086&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174306696 523966700 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578705 O=C(NCCCC[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2)C(=O)O)OCc1ccccc1 789086 UAMC-000-4060::US20250353833, Compound 34 Dipeptidyl peptidase 8 Homo sapiens 1.74 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789086&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174306696 523966700 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578706 O[C@H]1CC[C@@H](CC1)NC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |r,wU:4.7,wD:1.0,TLB:10:11:14:18.17.16,THB:19:11:14:18.17.16,19:17:14:33.12.11,20:17:14:33.12.11,12:13:16:33.11.19,12:11:14.13.18:16,(6.23,-4.67,;4.74,-5.07,;3.65,-3.98,;2.15,-4.38,;1.75,-5.87,;2.85,-6.96,;4.34,-6.56,;.26,-6.27,;-.83,-5.18,;-.43,-3.68,;-2.32,-5.58,;-3.41,-4.48,;-4.45,-4.97,;-5.16,-4.18,;-6.23,-3.98,;-5.08,-3.55,;-4.62,-2.61,;-3.63,-2.73,;-4.66,-3.18,;-2.93,-3.53,;-2.29,-1.96,;-2.29,-.42,;-.96,.35,;.38,-.42,;-.96,1.9,;.27,2.78,;-.2,4.28,;.57,5.63,;-.21,6.96,;-1.74,6.96,;-2.51,5.62,;-1.75,4.28,;-2.21,2.82,;-4.4,-4.27,)| 50629002 CHEMBL5405991::US20250353833, Compound 35 Dipeptidyl peptidase 8 Homo sapiens 399 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629002&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605877 505046974 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578707 O[C@H]1CC[C@@H](CC1)NC(=O)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |r,wU:4.7,wD:1.0,TLB:10:11:14:18.17.16,THB:19:11:14:18.17.16,19:17:14:33.12.11,20:17:14:33.12.11,12:13:16:33.11.19,12:11:14.13.18:16,(6.23,-4.67,;4.74,-5.07,;3.65,-3.98,;2.15,-4.38,;1.75,-5.87,;2.85,-6.96,;4.34,-6.56,;.26,-6.27,;-.83,-5.18,;-.43,-3.68,;-2.32,-5.58,;-3.41,-4.48,;-4.45,-4.97,;-5.16,-4.18,;-6.23,-3.98,;-5.08,-3.55,;-4.62,-2.61,;-3.63,-2.73,;-4.66,-3.18,;-2.93,-3.53,;-2.29,-1.96,;-2.29,-.42,;-.96,.35,;.38,-.42,;-.96,1.9,;.27,2.78,;-.2,4.28,;.57,5.63,;-.21,6.96,;-1.74,6.96,;-2.51,5.62,;-1.75,4.28,;-2.21,2.82,;-4.4,-4.27,)| 50629002 CHEMBL5405991::US20250353833, Compound 35 Dipeptidyl peptidase 8 Homo sapiens 7.31 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629002&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605877 505046974 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578708 O=C(NCc1ccccc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:10:11:14:18.17.16,THB:19:11:14:18.17.16,19:17:14:33.12.11,20:17:14:33.12.11,12:13:16:33.11.19,12:11:14.13.18:16| 50629007 CHEMBL5404995::US20250353833, Compound 36 Dipeptidyl peptidase 8 Homo sapiens 1150 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629007&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605938 505046979 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578709 O=C(NCc1ccccc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:10:11:14:18.17.16,THB:19:11:14:18.17.16,19:17:14:33.12.11,20:17:14:33.12.11,12:13:16:33.11.19,12:11:14.13.18:16| 50629007 CHEMBL5404995::US20250353833, Compound 36 Dipeptidyl peptidase 8 Homo sapiens 73.8 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629007&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605938 505046979 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578710 O=C(NCc1ccncc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:10:11:14:18.17.16,THB:19:11:14:18.17.16,19:17:14:33.12.11,20:17:14:33.12.11,12:13:16:33.11.19,12:11:14.13.18:16| 50629009 CHEMBL5438110::US20250353833, Compound 37 Dipeptidyl peptidase 8 Homo sapiens 1110 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629009&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605878 505046981 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578711 O=C(NCc1ccncc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:10:11:14:18.17.16,THB:19:11:14:18.17.16,19:17:14:33.12.11,20:17:14:33.12.11,12:13:16:33.11.19,12:11:14.13.18:16| 50629009 CHEMBL5438110::US20250353833, Compound 37 Dipeptidyl peptidase 8 Homo sapiens 90.8 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629009&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605878 505046981 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578712 O=C(NCCCc1ccccc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:12:13:16:20.19.18,THB:21:13:16:20.19.18,21:19:16:35.14.13,22:19:16:35.14.13,14:15:18:35.13.21,14:13:16.15.20:18| 50629012 CHEMBL5422425::US20250353833, Compound 38 Dipeptidyl peptidase 8 Homo sapiens 1010 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629012&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172456730 505046984 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578713 O=C(NCCCc1ccccc1)OC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:12:13:16:20.19.18,THB:21:13:16:20.19.18,21:19:16:35.14.13,22:19:16:35.14.13,14:15:18:35.13.21,14:13:16.15.20:18| 50629012 CHEMBL5422425::US20250353833, Compound 38 Dipeptidyl peptidase 8 Homo sapiens 3.79 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629012&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172456730 505046984 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578714 Fc1ccc(CNC(=O)OC23CC4CC(CC(C4)(C2)NCC(=O)N2Cc4ccccc4C2)C3)c(F)c1 |TLB:9:10:13:17.16.15,THB:18:10:13:17.16.15,18:16:13:32.11.10,19:16:13:32.11.10,11:12:15:32.10.18,11:10:13.12.17:15| 50629008 CHEMBL5401877::US20250353833, Compound 39 Dipeptidyl peptidase 8 Homo sapiens 823 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629008&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172444496 505046980 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578715 Fc1ccc(CNC(=O)OC23CC4CC(CC(C4)(C2)NCC(=O)N2Cc4ccccc4C2)C3)c(F)c1 |TLB:9:10:13:17.16.15,THB:18:10:13:17.16.15,18:16:13:32.11.10,19:16:13:32.11.10,11:12:15:32.10.18,11:10:13.12.17:15| 50629008 CHEMBL5401877::US20250353833, Compound 39 Dipeptidyl peptidase 8 Homo sapiens 6.03 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629008&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172444496 505046980 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578716 CC(C)(C)NC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:30.9.8,17:14:11:30.9.8,9:10:13:30.8.16,9:8:11.10.15:13| 50629027 CHEMBL5403872::US20250353833, Compound 40 Dipeptidyl peptidase 8 Homo sapiens 1050 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629027&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172444051 505046999 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578717 CC(C)(C)NC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:30.9.8,17:14:11:30.9.8,9:10:13:30.8.16,9:8:11.10.15:13| 50629027 CHEMBL5403872::US20250353833, Compound 40 Dipeptidyl peptidase 8 Homo sapiens 51.8 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629027&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172444051 505046999 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578718 O=C(CNC12CC3CC(C1)CC(C3)(C2)NC(=O)NC12CC3CC(CC(C3)C1)C2)N1Cc2ccccc2C1 |TLB:14:11:7:5.4.9,12:11:7.6.5:9,21:22:19.20.25:26,THB:13:11:7:5.4.9,13:4:7:10.12.11,23:22:19:25.24.26,23:24:19:27.21.22,3:4:7:10.12.11,12:6:9:10.11.13,21:20:26:27.22.23| 50629030 CHEMBL5400525::US20250353833, Compound 41 Dipeptidyl peptidase 8 Homo sapiens 592 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629030&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172440017 505047002 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578719 O=C(CNC12CC3CC(C1)CC(C3)(C2)NC(=O)NC12CC3CC(CC(C3)C1)C2)N1Cc2ccccc2C1 |TLB:14:11:7:5.4.9,12:11:7.6.5:9,21:22:19.20.25:26,THB:13:11:7:5.4.9,13:4:7:10.12.11,23:22:19:25.24.26,23:24:19:27.21.22,3:4:7:10.12.11,12:6:9:10.11.13,21:20:26:27.22.23| 50629030 CHEMBL5400525::US20250353833, Compound 41 Dipeptidyl peptidase 8 Homo sapiens 1.05 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629030&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172440017 505047002 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578720 O=C(CNC12CC3CC(C1)CC(C3)(C2)NC(=O)NCc1ccccc1)N1Cc2ccccc2C1 |TLB:14:11:7:5.4.9,12:11:7.6.5:9,THB:13:11:7:5.4.9,13:4:7:10.12.11,3:4:7:10.12.11,12:6:9:10.11.13| 50629031 CHEMBL5437013::US20250353833, Compound 42 Dipeptidyl peptidase 8 Homo sapiens 505 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629031&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606012 505047003 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578721 O=C(CNC12CC3CC(C1)CC(C3)(C2)NC(=O)NCc1ccccc1)N1Cc2ccccc2C1 |TLB:14:11:7:5.4.9,12:11:7.6.5:9,THB:13:11:7:5.4.9,13:4:7:10.12.11,3:4:7:10.12.11,12:6:9:10.11.13| 50629031 CHEMBL5437013::US20250353833, Compound 42 Dipeptidyl peptidase 8 Homo sapiens 37.8 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629031&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606012 505047003 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578722 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2)C1C2CC3CC(C2)CC1C3 789095 UAMC-000-4151::US20250353833, Compound 43 Dipeptidyl peptidase 8 Homo sapiens 5700 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789095&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184814 523966709 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578723 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2)C1C2CC3CC(C2)CC1C3 789095 UAMC-000-4151::US20250353833, Compound 43 Dipeptidyl peptidase 8 Homo sapiens 186 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789095&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184814 523966709 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578724 O=C(CCc1ccc(cc1)C#N)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:12:13:16:20.19.18,THB:21:13:16:20.19.18,21:19:16:35.14.13,22:19:16:35.14.13,14:15:18:35.13.21,14:13:16.15.20:18| 50629036 CHEMBL5401924::US20250353833, Compound 44 Dipeptidyl peptidase 8 Homo sapiens 638 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629036&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605860 505047008 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578725 O=C(CCc1ccc(cc1)C#N)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccccc3C1)C2 |TLB:12:13:16:20.19.18,THB:21:13:16:20.19.18,21:19:16:35.14.13,22:19:16:35.14.13,14:15:18:35.13.21,14:13:16.15.20:18| 50629036 CHEMBL5401924::US20250353833, Compound 44 Dipeptidyl peptidase 8 Homo sapiens 1.80 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629036&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605860 505047008 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578726 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C1C2CC3CC(C2)CC1C3 789097 UAMC-000-4290::US20250353833, Compound 45 Dipeptidyl peptidase 8 Homo sapiens 1176 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789097&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184815 523966711 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578727 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C1C2CC3CC(C2)CC1C3 789097 UAMC-000-4290::US20250353833, Compound 45 Dipeptidyl peptidase 8 Homo sapiens 38.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789097&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184815 523966711 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578728 CC(C)(C)OC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccc(F)cc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:31.9.8,17:14:11:31.9.8,9:10:13:31.8.16,9:8:11.10.15:13| 50629022 CHEMBL5421476::US20250353833, Compound 46 Dipeptidyl peptidase 8 Homo sapiens 824 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629022&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172455865 505046994 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578729 CC(C)(C)OC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccc(F)cc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:31.9.8,17:14:11:31.9.8,9:10:13:31.8.16,9:8:11.10.15:13| 50629022 CHEMBL5421476::US20250353833, Compound 46 Dipeptidyl peptidase 8 Homo sapiens 2.44 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629022&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172455865 505046994 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578730 NC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1Cc2ccc(F)cc2C1 |TLB:0:1:4:7.8.9,6:1:4.5.7:9,THB:10:1:4:7.8.9,10:8:4:2.6.1,11:8:4:2.6.1,6:5:9:2.1.10| 50628989 CHEMBL5433274::US20250353833, Compound 47 Dipeptidyl peptidase 8 Homo sapiens 2620 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50628989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50628989&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172463369 505046961 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578731 NC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1Cc2ccc(F)cc2C1 |TLB:0:1:4:7.8.9,6:1:4.5.7:9,THB:10:1:4:7.8.9,10:8:4:2.6.1,11:8:4:2.6.1,6:5:9:2.1.10| 50628989 CHEMBL5433274::US20250353833, Compound 47 Dipeptidyl peptidase 8 Homo sapiens 259 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50628989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50628989&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172463369 505046961 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578732 CC(C)(C)NC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccc(F)cc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:31.9.8,17:14:11:31.9.8,9:10:13:31.8.16,9:8:11.10.15:13| 50629028 CHEMBL5398643::US20250353833, Compound 48 Dipeptidyl peptidase 8 Homo sapiens 369 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629028&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172440470 505047000 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578733 CC(C)(C)NC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3ccc(F)cc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:31.9.8,17:14:11:31.9.8,9:10:13:31.8.16,9:8:11.10.15:13| 50629028 CHEMBL5398643::US20250353833, Compound 48 Dipeptidyl peptidase 8 Homo sapiens 4.00 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629028&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172440470 505047000 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578734 CC(C)(C)OC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3cc(F)c(F)cc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:32.9.8,17:14:11:32.9.8,9:10:13:32.8.16,9:8:11.10.15:13| 50629023 CHEMBL5402430::US20250353833, Compound 49 Dipeptidyl peptidase 8 Homo sapiens 613 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629023&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172439227 505046995 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578735 CC(C)(C)OC(=O)NC12CC3CC(CC(C3)(C1)NCC(=O)N1Cc3cc(F)c(F)cc3C1)C2 |TLB:7:8:11:15.14.13,THB:16:8:11:15.14.13,16:14:11:32.9.8,17:14:11:32.9.8,9:10:13:32.8.16,9:8:11.10.15:13| 50629023 CHEMBL5402430::US20250353833, Compound 49 Dipeptidyl peptidase 8 Homo sapiens 3.40 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629023&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172439227 505046995 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578736 O=C([O-])[C@@H]1CCCN1C(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789104 UAMC-000-4913::US20250353833, Compound 50 Dipeptidyl peptidase 8 Homo sapiens 920 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789104&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184816 523966718 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578737 O=C([O-])[C@@H]1CCCN1C(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789104 UAMC-000-4913::US20250353833, Compound 50 Dipeptidyl peptidase 8 Homo sapiens 8.03 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789104&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184816 523966718 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578738 CC(C)C[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(=O)[O-] 789105 UAMC-000-4912::US20250353833, Compound 51 Dipeptidyl peptidase 8 Homo sapiens 1080 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789105&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184817 523966719 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578739 CC(C)C[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(=O)[O-] 789105 UAMC-000-4912::US20250353833, Compound 51 Dipeptidyl peptidase 8 Homo sapiens 2.79 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789105&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184817 523966719 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578740 CSCC[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(=O)[O-] 789106 UAMC-000-4911::US20250353833, Compound 52 Dipeptidyl peptidase 8 Homo sapiens 504 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789106&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605914 523966720 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578741 CSCC[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(=O)[O-] 789106 UAMC-000-4911::US20250353833, Compound 52 Dipeptidyl peptidase 8 Homo sapiens 9.13 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789106&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605914 523966720 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578742 O=C([O-])CNC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789107 UAMC-000-4909::US20250353833, Compound 53 Dipeptidyl peptidase 8 Homo sapiens 1740 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789107&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184819 523966721 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578743 O=C([O-])CNC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789107 UAMC-000-4909::US20250353833, Compound 53 Dipeptidyl peptidase 8 Homo sapiens 4.70 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789107&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184819 523966721 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578744 NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789108 UAMC-000-4801::US20250353833, Compound 54 Dipeptidyl peptidase 8 Homo sapiens 243 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789108&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174306869 523966722 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578745 NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789108 UAMC-000-4801::US20250353833, Compound 54 Dipeptidyl peptidase 8 Homo sapiens 8.88 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789108&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174306869 523966722 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578746 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[O-])OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789109 UAMC-000-4910::US20250353833, Compound 55 Dipeptidyl peptidase 8 Homo sapiens 4.37 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789109&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184820 523966723 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578747 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[O-])OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789109 UAMC-000-4910::US20250353833, Compound 55 Dipeptidyl peptidase 8 Homo sapiens 6.55 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789109&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184820 523966723 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578748 CC[C@H](C)[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(=O)OC 789110 UAMC-000-4798::US20250353833, Compound 56 Dipeptidyl peptidase 8 Homo sapiens 2080 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789110&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606014 523966724 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578749 CC[C@H](C)[C@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(=O)OC 789110 UAMC-000-4798::US20250353833, Compound 56 Dipeptidyl peptidase 8 Homo sapiens 2.29 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789110&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606014 523966724 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578750 COC(=O)[C@@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(C)C 789111 UAMC-000-4796::US20250353833, Compound 57 Dipeptidyl peptidase 8 Homo sapiens 2180 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789111&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174306901 523966725 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578751 COC(=O)[C@@H](NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)C(C)C 789111 UAMC-000-4796::US20250353833, Compound 57 Dipeptidyl peptidase 8 Homo sapiens 1.72 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789111&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174306901 523966725 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578752 COc1ccc2c(c1)CN(C(=O)CNC13CC4CC(C1)CC(NC(=O)OC(C)(C)C)(C4)C3)C2 789112 UAMC-000-4927::US20250353833, Compound 59 Dipeptidyl peptidase 8 Homo sapiens 5220 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789112&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605989 523966726 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578753 COc1ccc2c(c1)CN(C(=O)CNC13CC4CC(C1)CC(NC(=O)OC(C)(C)C)(C4)C3)C2 789112 UAMC-000-4927::US20250353833, Compound 59 Dipeptidyl peptidase 8 Homo sapiens 309 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789112&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605989 523966726 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578754 COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789115 UAMC-000-4800::US20250353833, Compound 60 Dipeptidyl peptidase 8 Homo sapiens 689 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789115&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605856 523966729 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578755 COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789115 UAMC-000-4800::US20250353833, Compound 60 Dipeptidyl peptidase 8 Homo sapiens 4.71 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789115&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605856 523966729 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578756 COC(=O)[C@H](CCSC)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789116 UAMC-000-4794::US20250353833, Compound 61 Dipeptidyl peptidase 8 Homo sapiens 705 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789116&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605935 523966730 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578757 COC(=O)[C@H](CCSC)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789116 UAMC-000-4794::US20250353833, Compound 61 Dipeptidyl peptidase 8 Homo sapiens 6.12 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789116&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605935 523966730 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578758 COC(=O)[C@H](C)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789117 UAMC-000-4797::US20250353833, Compound 62 Dipeptidyl peptidase 8 Homo sapiens 1290 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789117&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605852 523966731 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578759 COC(=O)[C@H](C)NC(=O)OC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789117 UAMC-000-4797::US20250353833, Compound 62 Dipeptidyl peptidase 8 Homo sapiens 93.8 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789117&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605852 523966731 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578760 CC12CC3CC(C)(C1)CC(NCC(=O)N1Cc4ccc(F)cc4C1)(C3)C2 789118 UAMC-000-4803::US20250353833, Compound 63 Dipeptidyl peptidase 8 Homo sapiens 4780 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789118&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605918 523966732 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578761 CC12CC3CC(C)(C1)CC(NCC(=O)N1Cc4ccc(F)cc4C1)(C3)C2 789118 UAMC-000-4803::US20250353833, Compound 63 Dipeptidyl peptidase 8 Homo sapiens 443 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789118&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605918 523966732 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578762 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 50634823 CHEMBL5558218::US20250353833, Compound 73 Dipeptidyl peptidase 8 Homo sapiens 457 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634823&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605934 519655226 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578763 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 50634823 CHEMBL5558218::US20250353833, Compound 73 Dipeptidyl peptidase 8 Homo sapiens 16.0 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634823&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605934 519655226 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578764 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 50634824 CHEMBL5505931::US20250353833, Compound 74 Dipeptidyl peptidase 8 Homo sapiens 310 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634824&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605892 519655227 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578765 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 50634824 CHEMBL5505931::US20250353833, Compound 74 Dipeptidyl peptidase 8 Homo sapiens 19.0 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634824&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605892 519655227 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578766 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789126 UAMC-000-4925::US20250353833, Compound 75 Dipeptidyl peptidase 8 Homo sapiens 495 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789126&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969730 523966740 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578767 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 789126 UAMC-000-4925::US20250353833, Compound 75 Dipeptidyl peptidase 8 Homo sapiens 43.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789126&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969730 523966740 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578768 O=C1CCC(N2C(=O)c3cccc(NCCOCCOC(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)c3C2=O)C(=O)N1 789127 UAMC-000-4923::US20250353833, Compound 76 Dipeptidyl peptidase 8 Homo sapiens 8.00 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789127&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177779349 523966741 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578769 O=C1CCC(N2C(=O)c3cccc(NCCOCCOC(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)c3C2=O)C(=O)N1 789127 UAMC-000-4923::US20250353833, Compound 76 Dipeptidyl peptidase 8 Homo sapiens 1.40 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789127&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177779349 523966741 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578770 O=C1CCC(N2C(=O)c3cccc(NCCOCCNC(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)c3C2=O)C(=O)N1 789128 UAMC-000-4921::US20250353833, Compound 77 Dipeptidyl peptidase 8 Homo sapiens 21.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789128&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605916 523966742 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578771 O=C1CCC(N2C(=O)c3cccc(NCCOCCNC(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)c3C2=O)C(=O)N1 789128 UAMC-000-4921::US20250353833, Compound 77 Dipeptidyl peptidase 8 Homo sapiens 2.40 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789128&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605916 523966742 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578772 O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCNC(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)c3C2=O)C(=O)N1 789129 UAMC-000-4922::US20250353833, Compound 78 Dipeptidyl peptidase 8 Homo sapiens 79.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789129&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177779187 523966743 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578773 O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCNC(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)c3C2=O)C(=O)N1 789129 UAMC-000-4922::US20250353833, Compound 78 Dipeptidyl peptidase 8 Homo sapiens 12.0 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789129&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177779187 523966743 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578774 Cc1ccc2c(c1)CN(C(=O)CNC13CC4CC(C1)CC(NC(=O)OC(C)(C)C)(C4)C3)C2 789136 UAMC-000-5033::US20250353833, Inhibitor NF-2022-071 Dipeptidyl peptidase 8 Homo sapiens 4.71 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789136&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308164 523966750 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578775 Cc1ccc2c(c1)CN(C(=O)CNC13CC4CC(C1)CC(NC(=O)OC(C)(C)C)(C4)C3)C2 789136 UAMC-000-5033::US20250353833, Inhibitor NF-2022-071 Dipeptidyl peptidase 9 Homo sapiens 0.208 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789136&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308164 523966750 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578776 CC(C)(C)NC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 789137 UAMC-000-5036::US20250353833, Inhibitor UAMC0005036 Dipeptidyl peptidase 8 Homo sapiens 1.33 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789137&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 172453993 523966751 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578777 CC(C)(C)NC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 789137 UAMC-000-5036::US20250353833, Inhibitor UAMC0005036 Dipeptidyl peptidase 9 Homo sapiens 0.006 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789137&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 172453993 523966751 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578778 CC(C)(C)CC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 789138 UAMC-000-50 37::US20250353833, Inhibitor UAMC0005037 Dipeptidyl peptidase 8 Homo sapiens 1.30 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789138&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308165 523966752 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578779 CC(C)(C)CC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 789138 UAMC-000-50 37::US20250353833, Inhibitor UAMC0005037 Dipeptidyl peptidase 9 Homo sapiens 0.006 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789138&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308165 523966752 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578780 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2)cc1 789139 UAMC-000-5035::US20250353833, Inhibitor UAMC0005035 Dipeptidyl peptidase 8 Homo sapiens 0.276 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789139&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308222 523966753 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578781 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2)cc1 789139 UAMC-000-5035::US20250353833, Inhibitor UAMC0005035 Dipeptidyl peptidase 9 Homo sapiens 0.005 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789139&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308222 523966753 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578782 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2cccnc2)cc1 789140 UAMC-000-5111::US20250353833, Inhibitor UAMC0005111 Dipeptidyl peptidase 8 Homo sapiens 0.051 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789140&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308223 523966754 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578783 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2cccnc2)cc1 789140 UAMC-000-5111::US20250353833, Inhibitor UAMC0005111 Dipeptidyl peptidase 9 Homo sapiens 0.002 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789140&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308223 523966754 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578784 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2)nc1 789141 UAMC-000-5112::US20250353833, Inhibitor NF-2023-048 Dipeptidyl peptidase 8 Homo sapiens 0.145 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789141&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308224 523966755 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578785 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2)nc1 789141 UAMC-000-5112::US20250353833, Inhibitor NF-2023-048 Dipeptidyl peptidase 9 Homo sapiens 0.005 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789141&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308224 523966755 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578786 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccn2)cc1 789142 UAMC-000-5113::US20250353833, Inhibitor NF-2023-069 Dipeptidyl peptidase 8 Homo sapiens 0.127 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789142&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308226 523966756 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578787 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccn2)cc1 789142 UAMC-000-5113::US20250353833, Inhibitor NF-2023-069 Dipeptidyl peptidase 9 Homo sapiens 0.003 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789142&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308226 523966756 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578788 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccncc2)cc1 789143 UAMC-000-5114::US20250353833, Inhibitor UAMC-0005114 Dipeptidyl peptidase 8 Homo sapiens 0.102 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789143&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308253 523966757 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578789 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccncc2)cc1 789143 UAMC-000-5114::US20250353833, Inhibitor UAMC-0005114 Dipeptidyl peptidase 9 Homo sapiens 0.008 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789143&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308253 523966757 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578790 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2cccs2)cc1 789144 UAMC-000-5116::US20250353833, Inhibitor NF-2023-049 Dipeptidyl peptidase 8 Homo sapiens 0.222 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789144&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308254 523966758 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578791 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2cccs2)cc1 789144 UAMC-000-5116::US20250353833, Inhibitor NF-2023-049 Dipeptidyl peptidase 9 Homo sapiens 0.008 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789144&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308254 523966758 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578792 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccc(F)cc2)cc1 789146 UAMC-000-5356::US20250353833, Inhibitor NF-2023-050 Dipeptidyl peptidase 8 Homo sapiens 0.757 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789146&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308257 523966760 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578793 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccc(F)cc2)cc1 789146 UAMC-000-5356::US20250353833, Inhibitor NF-2023-050 Dipeptidyl peptidase 9 Homo sapiens 0.001 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789146&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308257 523966760 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578794 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2F)cc1 789147 UAMC-000-5357::US20250353833, Inhibitor NF-2023-051 Dipeptidyl peptidase 8 Homo sapiens 0.403 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789147&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174307447 523966761 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578795 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2F)cc1 789147 UAMC-000-5357::US20250353833, Inhibitor NF-2023-051 Dipeptidyl peptidase 9 Homo sapiens 0.002 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789147&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174307447 523966761 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578796 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(F)cc1 789149 UAMC-000-5359::US20250353833, Inhibitor NF-2023-053 Dipeptidyl peptidase 8 Homo sapiens 0.295 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789149&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308317 523966763 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578797 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(F)cc1 789149 UAMC-000-5359::US20250353833, Inhibitor NF-2023-053 Dipeptidyl peptidase 9 Homo sapiens 0.007 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789149&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308317 523966763 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578798 N#Cc1ccc(C(=O)NC23CC4CC(CC(NCC(=O)N5Cc6ccc(F)cc6C5)(C4)C2)C3)cc1 789155 UAMC-000-5360::US20250353833, Inhibitor NF-2023-054 Dipeptidyl peptidase 8 Homo sapiens 0.161 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789155&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605910 523966769 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578799 N#Cc1ccc(C(=O)NC23CC4CC(CC(NCC(=O)N5Cc6ccc(F)cc6C5)(C4)C2)C3)cc1 789155 UAMC-000-5360::US20250353833, Inhibitor NF-2023-054 Dipeptidyl peptidase 9 Homo sapiens 0.001 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789155&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605910 523966769 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578800 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2)s1 789156 UAMC-000-5361::US20250353833, Inhibitor NF-2023-055 Dipeptidyl peptidase 8 Homo sapiens 0.244 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789156&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308319 523966770 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578801 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccccc2)s1 789156 UAMC-000-5361::US20250353833, Inhibitor NF-2023-055 Dipeptidyl peptidase 9 Homo sapiens 0.002 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789156&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308319 523966770 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578802 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1cccnc1 789159 UAMC-000-5363::US20250353833, Inhibitor NF-2023-057 Dipeptidyl peptidase 8 Homo sapiens 0.270 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789159&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170606003 523966773 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578803 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1cccnc1 789159 UAMC-000-5363::US20250353833, Inhibitor NF-2023-057 Dipeptidyl peptidase 9 Homo sapiens 0.088 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789159&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170606003 523966773 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578804 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1cnc2ccccc2c1 789160 UAMC-000-5364::US20250353833, Inhibitor NF-2023-058 Dipeptidyl peptidase 8 Homo sapiens 0.001 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789160&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308320 523966774 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578805 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1cnc2ccccc2c1 789160 UAMC-000-5364::US20250353833, Inhibitor NF-2023-058 Dipeptidyl peptidase 9 Homo sapiens 0.003 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789160&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308320 523966774 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578806 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2cccs2)nc1 789162 UAMC-000-5365::US20250353833, Inhibitor NF-2023-059 Dipeptidyl peptidase 8 Homo sapiens 0.117 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789162&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308379 523966776 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578807 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2cccs2)nc1 789162 UAMC-000-5365::US20250353833, Inhibitor NF-2023-059 Dipeptidyl peptidase 9 Homo sapiens 0.005 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789162&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308379 523966776 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578808 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1cccc(-c2ccccc2)c1 789163 UAMC-000-5366::US20250353833, Inhibitor NF-2023-060 Dipeptidyl peptidase 8 Homo sapiens 0.006 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789163&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308382 523966777 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578809 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1cccc(-c2ccccc2)c1 789163 UAMC-000-5366::US20250353833, Inhibitor NF-2023-060 Dipeptidyl peptidase 9 Homo sapiens 0.004 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789163&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308382 523966777 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578810 O=C(CNC12CC3CC(C1)CC(NS(=O)(=O)c1ccc(-c4ccccc4)cc1)(C3)C2)N1Cc2ccc(F)cc2C1 789164 UAMC-000-5444::US20250353833, Inhibitor UAMC-0005444 Dipeptidyl peptidase 8 Homo sapiens 5.12 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789164&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308387 523966778 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578811 O=C(CNC12CC3CC(C1)CC(NS(=O)(=O)c1ccc(-c4ccccc4)cc1)(C3)C2)N1Cc2ccc(F)cc2C1 789164 UAMC-000-5444::US20250353833, Inhibitor UAMC-0005444 Dipeptidyl peptidase 9 Homo sapiens 1.25 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789164&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308387 523966778 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578812 COC(=O)c1csc(-c2ccc(C(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)cc2)c1 789165 UAMC-000-5377::US20250353833, Inhibitor MFE-2022-192 Dipeptidyl peptidase 8 Homo sapiens 0.005 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789165&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605885 523966779 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578813 COC(=O)c1csc(-c2ccc(C(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)cc2)c1 789165 UAMC-000-5377::US20250353833, Inhibitor MFE-2022-192 Dipeptidyl peptidase 9 Homo sapiens 0.002 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789165&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605885 523966779 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578814 COC(=O)c1ccc(-c2ccc(C(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)cc2)cc1 789167 UAMC-000-5376::US20250353833, Inhibitor MFE-2022-186 Dipeptidyl peptidase 8 Homo sapiens 0.005 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789167&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174308393 523966781 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578815 COC(=O)c1ccc(-c2ccc(C(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)cc2)cc1 789167 UAMC-000-5376::US20250353833, Inhibitor MFE-2022-186 Dipeptidyl peptidase 9 Homo sapiens 0.001 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789167&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174308393 523966781 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578816 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccc(O)cc2)cc1 789168 UAMC-000-5378::US20250353833, Inhibitor MFE-2022-203 Dipeptidyl peptidase 8 Homo sapiens 0.476 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789168&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605979 523966782 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578817 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2)c1ccc(-c2ccc(O)cc2)cc1 789168 UAMC-000-5378::US20250353833, Inhibitor MFE-2022-203 Dipeptidyl peptidase 9 Homo sapiens 0.001 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789168&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605979 523966782 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578818 O=C(CNC12CC3CC(C1)CC(Nc1ccc(-c4ccccc4)nc1)(C3)C2)N1Cc2ccc(F)cc2C1 789169 UAMC-000-5379::US20250353833, Inhibitor MFE-2022-212 Dipeptidyl peptidase 8 Homo sapiens 0.009 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789169&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605871 523966783 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578819 O=C(CNC12CC3CC(C1)CC(Nc1ccc(-c4ccccc4)nc1)(C3)C2)N1Cc2ccc(F)cc2C1 789169 UAMC-000-5379::US20250353833, Inhibitor MFE-2022-212 Dipeptidyl peptidase 9 Homo sapiens 0.006 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789169&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605871 523966783 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578820 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 50634827 CHEMBL5558204::US20250353833, Inhibitor MFE-2022-119 Dipeptidyl peptidase 8 Homo sapiens 0.541 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634827&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969780 519655230 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578821 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 50634827 CHEMBL5558204::US20250353833, Inhibitor MFE-2022-119 Dipeptidyl peptidase 9 Homo sapiens 0.050 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634827&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969780 519655230 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578822 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 50634826 CHEMBL5555956::US20250353833, Inhibitor MFE-2022-122 Dipeptidyl peptidase 8 Homo sapiens 0.876 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634826&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969840 519655229 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578823 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 50634826 CHEMBL5555956::US20250353833, Inhibitor MFE-2022-122 Dipeptidyl peptidase 9 Homo sapiens 0.004 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634826&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969840 519655229 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578824 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 789172 UAMC-000-5032::US20250353833, Inhibitor MFE-2022-124 Dipeptidyl peptidase 8 Homo sapiens 0.812 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789172&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969747 523966786 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578825 O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOCCOCCNC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 789172 UAMC-000-5032::US20250353833, Inhibitor MFE-2022-124 Dipeptidyl peptidase 9 Homo sapiens 0.113 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789172&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969747 523966786 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578826 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2)OCCOCCNc1ccc([N+](=O)[O-])c2nonc12 50634819 CHEMBL5527979::US20250353833, Inhibitor MFE-2022-109 Dipeptidyl peptidase 8 Homo sapiens 0.210 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634819&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605998 519655222 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578827 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2)OCCOCCNc1ccc([N+](=O)[O-])c2nonc12 50634819 CHEMBL5527979::US20250353833, Inhibitor MFE-2022-109 Dipeptidyl peptidase 9 Homo sapiens 0.004 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634819&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605998 519655222 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578828 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2)OCCOCCNc1ccc([N+](=O)[O-])c2nonc12 50634819 CHEMBL5527979::US20250353833, Inhibitor MFE-2022-109 Dipeptidyl peptidase 8 Homo sapiens 0.418 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634819&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605998 519655222 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578829 O=C(NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2)OCCOCCNc1ccc([N+](=O)[O-])c2nonc12 50634819 CHEMBL5527979::US20250353833, Inhibitor MFE-2022-109 Dipeptidyl peptidase 9 Homo sapiens 0.002 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634819&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605998 519655222 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578830 CN(C)c1cccc2c(S(=O)(=O)NCCOCCOC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)cccc12 50634820 CHEMBL5559023::US20250353833, Inhibitor MFE-2022-101 Dipeptidyl peptidase 8 Homo sapiens 0.066 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634820&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 174307716 519655223 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578831 CN(C)c1cccc2c(S(=O)(=O)NCCOCCOC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)cccc12 50634820 CHEMBL5559023::US20250353833, Inhibitor MFE-2022-101 Dipeptidyl peptidase 9 Homo sapiens 0.004 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634820&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 174307716 519655223 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578832 CN(C)c1cccc2c(S(=O)(=O)NCCOCCOC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7cc(F)c(F)cc7C6)(C5)C3)C4)cccc12 50634821 CHEMBL5555335::US20250353833, Inhibitor MFE-2022-114 Dipeptidyl peptidase 8 Homo sapiens 0.007 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634821&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605941 519655224 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578833 CN(C)c1cccc2c(S(=O)(=O)NCCOCCOC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7cc(F)c(F)cc7C6)(C5)C3)C4)cccc12 50634821 CHEMBL5555335::US20250353833, Inhibitor MFE-2022-114 Dipeptidyl peptidase 9 Homo sapiens 0.007 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634821&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605941 519655224 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578834 CC[N+]1=C(/C=C/C=C2/N(CCCCCC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)c3ccc(S(=O)(=O)O)cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)[O-])ccc21 789177 UAMC-000-5156::US20250353833, Inhibitor MFE-2022-126 Dipeptidyl peptidase 8 Homo sapiens 0.835 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789177&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 178184823 523966791 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578835 CC[N+]1=C(/C=C/C=C2/N(CCCCCC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7ccc(F)cc7C6)(C5)C3)C4)c3ccc(S(=O)(=O)O)cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)[O-])ccc21 789177 UAMC-000-5156::US20250353833, Inhibitor MFE-2022-126 Dipeptidyl peptidase 9 Homo sapiens 0.005 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789177&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 178184823 523966791 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578836 CC[N+]1=C(/C=C/C=C2/N(CCCCCC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7cc(F)c(F)cc7C6)(C5)C3)C4)c3ccc(S(=O)(=O)O)cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)[O-])ccc21 50634822 CHEMBL5558252::US20250353833, Inhibitor MFE-2022-136 Dipeptidyl peptidase 8 Homo sapiens 1.12 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634822&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177373700 519655225 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578837 CC[N+]1=C(/C=C/C=C2/N(CCCCCC(=O)NC34CC5CC(CC(NCC(=O)N6Cc7cc(F)c(F)cc7C6)(C5)C3)C4)c3ccc(S(=O)(=O)O)cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)[O-])ccc21 50634822 CHEMBL5558252::US20250353833, Inhibitor MFE-2022-136 Dipeptidyl peptidase 9 Homo sapiens 0.054 US Patent US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50634822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50634822&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 177373700 519655225 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578838 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)c2csc(-c3ccc(C(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)cc3)c2)C(C)(C)C)cc1 789179 UAMC-000-5381::US20250353833, Inhibitor MFE-2022-197 Dipeptidyl peptidase 8 Homo sapiens 0.793 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789179&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177779334 523966793 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578839 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)c2csc(-c3ccc(C(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)cc3)c2)C(C)(C)C)cc1 789179 UAMC-000-5381::US20250353833, Inhibitor MFE-2022-197 Dipeptidyl peptidase 9 Homo sapiens 0.070 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789179&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 177779334 523966793 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578840 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)c2ccc(-c3ccc(C(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)cc3)cc2)C(C)(C)C)cc1 789180 UAMC-000-5380::US20250353833, Inhibitor MFE-2022-189 Dipeptidyl peptidase 8 Homo sapiens 0.008 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789180&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 170605888 523966794 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578841 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)c2ccc(-c3ccc(C(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)cc3)cc2)C(C)(C)C)cc1 789180 UAMC-000-5380::US20250353833, Inhibitor MFE-2022-189 Dipeptidyl peptidase 9 Homo sapiens 0.173 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789180&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 170605888 523966794 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578842 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCC(=O)NC23CC4CC(CC(NCC(=O)N5Cc6ccc(F)cc6C5)(C4)C2)C3)C(C)(C)C)cc1 789181 UAMC-000-5215::US20250353833, Inhibitor MFE-2022-147 Dipeptidyl peptidase 8 Homo sapiens 0.094 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789181&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 175969872 523966795 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578843 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCC(=O)NC23CC4CC(CC(NCC(=O)N5Cc6ccc(F)cc6C5)(C4)C2)C3)C(C)(C)C)cc1 789181 UAMC-000-5215::US20250353833, Inhibitor MFE-2022-147 Dipeptidyl peptidase 9 Homo sapiens 0.009 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789181&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 175969872 523966795 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 1578844 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOc2ccc(-c3ccc(C(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)cc3)cc2)C(C)(C)C)cc1 789182 UAMC-000-5382::US20250353833, Inhibitor MFE-2022-217 Dipeptidyl peptidase 8 Homo sapiens 0.127 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1236&target=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789182&enzyme=Dipeptidyl+peptidase+8&column=ki&startPg=0&Increment=50&submit=Search 177779346 523966796 1 MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI 7SVO,6TRX,6TRW,7SVM,7OZ7,7OR4,7AYR,7AYQ,7A3L,7A3K,7A3J,7A3I,7A3G,6QZW,6HP8,6EOT,6EOS,6EOP,6EOO Dipeptidyl peptidase 8 DPP8_HUMAN Q6V1X1 Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5 Q9NXF4 N/A A0A024R5Z6 1578845 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOc2ccc(-c3ccc(C(=O)NC45CC6CC(CC(NCC(=O)N7Cc8ccc(F)cc8C7)(C6)C4)C5)cc3)cc2)C(C)(C)C)cc1 789182 UAMC-000-5382::US20250353833, Inhibitor MFE-2022-217 Dipeptidyl peptidase 9 Homo sapiens 0.001 US Patent 10.7270/Q29C7377 US20250353833 AUGUSTYNS, K; BENRAMDANE, S; BEYENS, O; DE LOOSE, J; DE MEESTER, I; DE WINTER, H; ESPADINHA, M; FILIPPI, N; VAN DER VEKEN, P 11/20/2025 3/10/2026 UNIVERSITEIT ANTWERPEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1237&target=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789182&enzyme=Dipeptidyl+peptidase+9&column=ki&startPg=0&Increment=50&submit=Search 177779346 523966796 1 MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL 7JN7,7A3F,6X6C,6QZV,7JKQ,6X6A,7SVN,7SVL,6EOR,6EOQ,9GON,9GOD,7ZXS,7CRW Dipeptidyl peptidase 9 DPP9_HUMAN Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3