BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 95622 COc1ccc(COc2ccc(Cc3ccnc4cc(OC)ccc34)cc2OC)cc1 InChI=1S/C24H22N2O6/c1-14-6-8-18(32-14)22(27)20-21(16-7-9-17(30-2)19(11-16)31-3)26(24(29)23(20)28)13-15-5-4-10-25-12-15/h4-12,20-21H,13H2,1-3H3 DNPKYEGYXICBIC-UHFFFAOYSA-N 66880 US20250360145, Example 1 Macrophage colony-stimulating factor 1 receptor Homo sapiens 7.50 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66880&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254678 252645194 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95623 COc1ccc(COc2ccc(Cc3ccnc4cnccc34)cc2OC)cc1 InChI=1S/C18H18ClN5O3S2/c1-10(2)16-23-24-17(28-16)22-15(25)14-13(19)8-20-18(21-14)29(26,27)9-12-6-4-5-11(3)7-12/h4-8,10H,9H2,1-3H3,(H,22,24,25) UMBCEWOZRUBUBU-UHFFFAOYSA-N 66887 US20250360145, Example 2 Macrophage colony-stimulating factor 1 receptor Homo sapiens 13.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66887&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968973 252645201 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95624 COc1ccc(COc2ccc(Cc3ccnc4ccccc34)cc2OC)cc1 InChI=1S/C17H23BrN2O4S/c18-14-3-5-16(6-4-14)25(22,23)20-9-7-13(8-10-20)17(21)19-12-15-2-1-11-24-15/h3-6,13,15H,1-2,7-12H2,(H,19,21) LIWYNOZMEPWZLB-UHFFFAOYSA-N 66897 US20250360145, Example 3 Macrophage colony-stimulating factor 1 receptor Homo sapiens 26.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66897&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968977 252645210 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95625 COc1ccc(COc2ccc(Cc3ccnc4cc(OC)cnc34)cc2OC)cc1 InChI=1S/C19H20N2O3S/c1-3-14-11-17(25-13(14)2)19(23)24-12-18(22)21-10-9-16(20-21)15-7-5-4-6-8-15/h4-8,11H,3,9-10,12H2,1-2H3 PTGPLMZMHWFKRC-UHFFFAOYSA-N 66899 US20250360145, Example 4 Macrophage colony-stimulating factor 1 receptor Homo sapiens 8.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66899&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254692 252645212 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95626 COc1ccc(COc2ccc(Cc3ncnc4cc(OC)ccc34)cc2OC)cc1 InChI=1S/C23H20F2N2O3/c1-27(14-22(28)26-19-12-10-18(25)11-13-19)23(29)20-4-2-3-5-21(20)30-15-16-6-8-17(24)9-7-16/h2-13H,14-15H2,1H3,(H,26,28) YOEMWRUJHXQPHH-UHFFFAOYSA-N 66900 US20250360145, Example 5 Macrophage colony-stimulating factor 1 receptor Homo sapiens 21.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66900&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254693 252645213 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95627 COc1ccc2c(Cc3ccc(OCc4ccn5ccnc5c4)c(OC)c3)ccnc2c1 InChI=1S/C23H26N2O4/c1-29-23(28)19-9-7-18(8-10-19)15-24-22(27)20-11-12-21(26)25(16-20)14-13-17-5-3-2-4-6-17/h2-10,20H,11-16H2,1H3,(H,24,27) QWKGPJQXTBQZCX-UHFFFAOYSA-N 66901 US20250360145, Example 6 Macrophage colony-stimulating factor 1 receptor Homo sapiens 8.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66901&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968980 252645214 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95628 COc1ccc2c(Cc3ccc(OCc4ccc5nccn5c4)c(OC)c3)ccnc2c1 InChI=1S/C22H25N3O5/c1-15-17(23-21(30-15)16-6-7-18(27-2)20(13-16)28-3)14-24-8-10-25(11-9-24)22(26)19-5-4-12-29-19/h4-7,12-13H,8-11,14H2,1-3H3 IONXESWWCOXTFC-UHFFFAOYSA-N 66902 US20250360145, Example 7 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.30 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66902&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254694 252645215 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95629 COc1ccc2c(Cc3ccc(OCc4cccnc4)c(OC)c3)ccnc2c1 InChI=1S/C25H26FN3O3/c1-31-24-14-18(10-11-21(24)26)16-29-13-5-6-19(17-29)25(30)28-22-8-2-3-9-23(22)32-20-7-4-12-27-15-20/h2-4,7-12,14-15,19H,5-6,13,16-17H2,1H3,(H,28,30) AAKSNWHRVQHZEW-UHFFFAOYSA-N 66903 US20250360145, Example 8 Macrophage colony-stimulating factor 1 receptor Homo sapiens 81.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66903&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968978 252645216 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95630 COc1ccc2c(Cc3ccc(OCc4ccccn4)c(OC)c3)ccnc2c1 InChI=1S/C19H15N3O6/c1-27-14-8-9-15(20-19(24)17-3-2-10-28-17)16(11-14)21-18(23)12-4-6-13(7-5-12)22(25)26/h2-11H,1H3,(H,20,24)(H,21,23) NLHKSOASBJKCDF-UHFFFAOYSA-N 66904 US20250360145, Example 9 Macrophage colony-stimulating factor 1 receptor Homo sapiens 169 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66904&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254695 252645217 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95631 COc1ccc2c(Cc3ccc(OCc4ccncc4)c(OC)c3)ccnc2c1 InChI=1S/C16H16N4O5S/c1-10(2)15-18-19-16(26-15)17-13(21)9-25-14(22)8-5-11-3-6-12(7-4-11)20(23)24/h3-8,10H,9H2,1-2H3,(H,17,19,21) DURGAROOKWMFDS-UHFFFAOYSA-N 66905 US20250360145, Example 10 Macrophage colony-stimulating factor 1 receptor Homo sapiens 118 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66905&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254696 252645218 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95632 COc1ccc2c(Cc3ccc(OCc4nc5ccccc5n4C)c(OC)c3)ccnc2c1 InChI=1S/C21H19N3O4S/c1-13-5-7-17(10-14(13)2)29-21-18(4-3-9-22-21)20(26)23-12-15-11-16(24(27)28)6-8-19(15)25/h3-11,25H,12H2,1-2H3,(H,23,26) UANNMXZDXLHHQF-UHFFFAOYSA-N 66906 US20250360145, Example 11 Macrophage colony-stimulating factor 1 receptor Homo sapiens 149 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66906&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254697 252645219 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95633 COc1ccc2c(Cc3ccc(OCc4ccc5cnn(C)c5c4)c(OC)c3)ccnc2c1 InChI=1S/C18H13F4N3O/c1-10(11-2-4-12(5-3-11)25-7-6-23-9-25)24-18(26)13-8-14(19)16(21)17(22)15(13)20/h2-10H,1H3,(H,24,26) VAZWTRSVWFOPEK-UHFFFAOYSA-N 66907 US20250360145, Example 12 Macrophage colony-stimulating factor 1 receptor Homo sapiens 299 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66907&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254698 252645220 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95634 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)ccc34)cc2OC)nc1 InChI=1S/C22H27N3O3S2/c1-16-7-9-18(10-8-16)30(27,28)25-21(12-14-29-2)22(26)23-13-11-17-15-24-20-6-4-3-5-19(17)20/h3-10,15,21,24-25H,11-14H2,1-2H3,(H,23,26) LOKYWESSMYIPST-UHFFFAOYSA-N 66908 US20250360145, Example 13 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.80 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66908&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176311401 252645221 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95635 COc1ccc2c(Cc3ccc(OCc4ccc(C(F)(F)F)cc4)c(OC)c3)ccnc2c1 InChI=1S/C20H25NO4/c1-15-4-7-17(8-5-15)25-13-11-20(22)21-12-10-16-6-9-18(23-2)19(14-16)24-3/h4-9,14H,10-13H2,1-3H3,(H,21,22) BZJBAKQMOVGJJW-UHFFFAOYSA-N 66909 US20250360145, Example 14 Macrophage colony-stimulating factor 1 receptor Homo sapiens 118 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66909&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254699 252645222 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95636 COc1ccc(COc2ncc(Cc3ccnc4cccnc34)cc2OC)nc1 InChI=1S/C21H27NO5S/c1-11-9-14(15(20(24)25)10-12(11)2)18(23)22-19-17(21(26)27-3)13-7-5-4-6-8-16(13)28-19/h14-15H,4-10H2,1-3H3,(H,22,23)(H,24,25) YYFJXWVWFNDEQO-UHFFFAOYSA-N 66911 US20250360145, Example 15 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.80 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66911&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968972 252645224 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95637 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C22H26N2O2/c25-21(19-13-7-4-8-14-19)23-20(17-18-11-5-3-6-12-18)22(26)24-15-9-1-2-10-16-24/h3-8,11-14,20H,1-2,9-10,15-17H2,(H,23,25) GELXWPLRAJVJNR-UHFFFAOYSA-N 66912 US20250360145, Example 16 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66912&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176311404 252645225 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95638 COc1ccc(COc2ccc(Cc3ccnc4ccncc34)cc2OC)cc1 InChI=1S/C23H27N5O2/c1-16(2)14-19(21(29)24-15-17-8-4-3-5-9-17)26-23(30)28-13-12-27-20-11-7-6-10-18(20)25-22(27)28/h3-11,16,19H,12-15H2,1-2H3,(H,24,29)(H,26,30) YLKYOZDWENUEAE-UHFFFAOYSA-N 66913 US20250360145, Example 17 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66913&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254700 252645226 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95639 COc1ccc2c(Cc3ccc(OCc4cn5ccccc5n4)c(OC)c3)ccnc2c1 InChI=1S/C21H22N2O6S/c1-3-4-14-11-20(25)29-18-10-13(2)9-17(21(14)18)28-12-19(24)23-15-5-7-16(8-6-15)30(22,26)27/h5-11H,3-4,12H2,1-2H3,(H,23,24)(H2,22,26,27) PKAFMNGRPDYQKC-UHFFFAOYSA-N 66914 US20250360145, Example 18 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66914&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968983 252645227 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95640 COc1ccc(COc2ncc(Cc3ccnc4cnccc34)cc2OC)nc1 InChI=1S/C22H28N4O5S/c1-16(21(27)24-15-17-7-11-23-12-8-17)25-22(28)18-9-13-26(14-10-18)32(29,30)20-5-3-19(31-2)4-6-20/h3-8,11-12,16,18H,9-10,13-15H2,1-2H3,(H,24,27)(H,25,28) ALGXZJXHMXLHEL-UHFFFAOYSA-N 66915 US20250360145, Example 19 Macrophage colony-stimulating factor 1 receptor Homo sapiens 47.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66915&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968985 252645228 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95641 COc1ccc2c(Cc3ccc(OCc4ccc5ccnn5c4)c(OC)c3)ccnc2c1 InChI=1S/C17H23FN2O2/c1-20(12-13-7-9-15(18)10-8-13)16(21)11-19-17(22)14-5-3-2-4-6-14/h7-10,14H,2-6,11-12H2,1H3,(H,19,22) NPPXRGOSPAQGKG-UHFFFAOYSA-N 66916 US20250360145, Example 20 Macrophage colony-stimulating factor 1 receptor Homo sapiens 11.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66916&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254701 252645229 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95642 COc1ccc2c(Cc3ccc(OCc4ccc5ncnn5c4)c(OC)c3)ccnc2c1 InChI=1S/C25H31N3O4/c1-16(2)23(25(31)26-17(3)18-8-6-5-7-9-18)27-24(30)19-14-22(29)28(15-19)20-10-12-21(32-4)13-11-20/h5-13,16-17,19,23H,14-15H2,1-4H3,(H,26,31)(H,27,30) FOTXUKGIOQXFTE-UHFFFAOYSA-N 66917 US20250360145, Example 21 Macrophage colony-stimulating factor 1 receptor Homo sapiens 12.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66917&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254702 252645230 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95643 COc1ccc(COc2ncc(Cc3ccnc4cncnc34)cc2OC)nc1 InChI=1S/C17H19N3O3/c1-13(15-8-5-11-23-15)19-20-17(22)10-9-16(21)18-12-14-6-3-2-4-7-14/h2-8,11H,9-10,12H2,1H3,(H,18,21)(H,20,22) JYGXPHKHBFYLTO-UHFFFAOYSA-N 66919 US20250360145, Example 22 Macrophage colony-stimulating factor 1 receptor Homo sapiens 64.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66919&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175969011 252645232 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95644 COc1ccc2c(Cc3ccc(OCc4cc(C)nn4C)c(OC)c3)ccnc2c1 InChI=1S/C26H22N2O5/c1-15-10-19-11-18(7-8-21(19)33-15)24(30)22-23(17-5-2-6-20(29)12-17)28(26(32)25(22)31)14-16-4-3-9-27-13-16/h2-9,11-13,15,22-23,29H,10,14H2,1H3 YOEWXZBNIDXWIZ-UHFFFAOYSA-N 66921 US20250360145, Example 23 Macrophage colony-stimulating factor 1 receptor Homo sapiens 8.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66921&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254703 252645234 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95645 COc1ccc(COc2ccc(Cc3ccnc4ccc(F)cc34)cc2OC)cc1 InChI=1S/C22H26N6O3S/c1-3-27-12-14-28(15-13-27)22-21(24-19-6-4-5-7-20(19)25-22)26-32(30,31)18-10-8-17(9-11-18)23-16(2)29/h4-11H,3,12-15H2,1-2H3,(H,23,29)(H,24,26) LEPCWMADTGGEOV-UHFFFAOYSA-N 66922 US20250360145, Example 24 Macrophage colony-stimulating factor 1 receptor Homo sapiens 25.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66922&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254704 252645235 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95646 COc1ccc2c(Cc3ccc(OCc4ccn(C)c(=O)c4)c(OC)c3)ccnc2c1 InChI=1S/C16H14BrFN4OS/c1-8-3-4-10(5-12(8)18)20-14(23)7-24-16-21-13-6-11(17)9(2)19-15(13)22-16/h3-6H,7H2,1-2H3,(H,20,23)(H,19,21,22) KGFUGPDGDDNTHP-UHFFFAOYSA-N 66923 US20250360145, Example 25 Macrophage colony-stimulating factor 1 receptor Homo sapiens 40.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66923&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254705 252645236 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95647 COc1ccc2c(Cc3ccc(OCc4ccc(=O)n(C)c4)c(OC)c3)ccnc2c1 InChI=1S/C13H18N2O4S/c1-19-12-7-6-10(8-11(12)13(14)16)20(17,18)15-9-4-2-3-5-9/h6-9,15H,2-5H2,1H3,(H2,14,16) FUGPIJDGQLOCND-UHFFFAOYSA-N 66924 US20250360145, Example 26 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66924&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254706 252645237 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95648 COc1ccc2c(Cc3ccc(OCc4cccc(C(F)(F)F)c4)c(OC)c3)ccnc2c1 InChI=1S/C26H35N3O2/c1-20(21-7-4-3-5-8-21)27-26(30)22-9-6-10-25(19-22)31-24-13-17-29(18-14-24)23-11-15-28(2)16-12-23/h3-10,19-20,23-24H,11-18H2,1-2H3,(H,27,30) ASMVYMMPTIHPFE-UHFFFAOYSA-N 66925 US20250360145, Example 27 Macrophage colony-stimulating factor 1 receptor Homo sapiens 117 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66925&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254707 252645238 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95649 COc1cccc(COc2ccc(Cc3ccnc4cc(OC)ccc34)cc2OC)c1 InChI=1S/C26H29N5O2/c1-29-17-19(21-7-3-5-9-23(21)29)18-30-15-12-20(13-16-30)31-25(11-14-27-31)28-26(32)22-8-4-6-10-24(22)33-2/h3-11,14,17,20H,12-13,15-16,18H2,1-2H3,(H,28,32) BJTKXFBFOMTTGV-UHFFFAOYSA-N 66926 US20250360145, Example 28 Macrophage colony-stimulating factor 1 receptor Homo sapiens 25.7 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66926&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254708 252645239 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95650 COc1ccc2c(Cc3ccc(OCc4ccccc4OC)c(OC)c3)ccnc2c1 InChI=1S/C16H18N4O3/c21-13-9-15-14(22-11-23-15)8-12(13)10-19-4-6-20(7-5-19)16-17-2-1-3-18-16/h1-3,8-9,21H,4-7,10-11H2 ARCOXMPSRJYGRO-UHFFFAOYSA-N 66927 US20250360145, Example 29 Macrophage colony-stimulating factor 1 receptor Homo sapiens 73.9 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66927 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66927&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254709 252645240 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95651 COc1ccc2c(Cc3ccc(OCc4ccn5nccc5c4)c(OC)c3)ccnc2c1 InChI=1S/C26H30N2O5/c1-3-4-20-15-25(30)33-26-18(2)23(10-9-22(20)26)32-17-24(29)27-21-7-5-19(6-8-21)16-28-11-13-31-14-12-28/h5-10,15H,3-4,11-14,16-17H2,1-2H3,(H,27,29) XOYJNIWANMLYMC-UHFFFAOYSA-N 66928 US20250360145, Example 30 Macrophage colony-stimulating factor 1 receptor Homo sapiens 7.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66928&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254710 252645241 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95652 COc1ccc2c(Cc3cnc(OCc4cnn(C)c4)c(OC)c3)ccnc2c1 InChI=1S/C11H9N3O4S2/c15-14(16)10-1-3-11(4-2-10)20(17,18)13-12-7-9-5-6-19-8-9/h1-8,13H JOBYFKGRQHCJLQ-UHFFFAOYSA-N 66929 US20250360145, Example 31 Macrophage colony-stimulating factor 1 receptor Homo sapiens 21.3 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66929 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66929&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254711 252645242 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95653 COc1cnc2c(Cc3cnc(OCc4ccc(OC)nn4)c(OC)c3)ccnc2c1 InChI=1S/C15H17ClN2O3S/c1-9-4-2-3-7-15(9)13(20)18(14(21)17-15)8-10(19)11-5-6-12(16)22-11/h5-6,9H,2-4,7-8H2,1H3,(H,17,21) FJBQBCDURZYSQK-UHFFFAOYSA-N 66930 US20250360145, Example 32 Macrophage colony-stimulating factor 1 receptor Homo sapiens 20.1 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66930 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66930&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175969012 252645243 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95654 COc1ccc2c(Cc3ccc(OCc4ccc5c(c4)OC(F)(F)O5)c(OC)c3)ccnc2c1 InChI=1S/C23H31N9O2/c1-15-9-11-31(12-10-15)14-18-19(26-30-32(18)21-20(24)28-34-29-21)22(33)27-25-13-16-5-7-17(8-6-16)23(2,3)4/h5-8,13,15H,9-12,14H2,1-4H3,(H2,24,28)(H,27,33) FVYRESBJFDVTOG-UHFFFAOYSA-N 66931 US20250360145, Example 33 Macrophage colony-stimulating factor 1 receptor Homo sapiens 203 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66931&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254712 252645244 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95655 COc1ccc2c(Cc3ccc(OCc4cc(C)no4)c(OC)c3)ccnc2c1 InChI=1S/C21H28N2O3S/c1-18-10-6-7-13-21(18)27(25,26)23(19-11-4-2-5-12-19)17-20(24)16-22-14-8-3-9-15-22/h2,4-7,10-13,20,24H,3,8-9,14-17H2,1H3 MKBRMWNQVUSPSU-UHFFFAOYSA-N 66932 US20250360145, Example 34 Macrophage colony-stimulating factor 1 receptor Homo sapiens 23.2 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66932&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254713 252645245 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95656 COc1ccc2c(Cc3ccc(OCc4cnc(C)s4)c(OC)c3)ccnc2c1 InChI=1S/C26H26N2O7/c1-16-13-24(30)35-25-17(2)19(8-7-18(16)25)33-15-23(29)27-9-11-28(12-10-27)26(31)22-14-32-20-5-3-4-6-21(20)34-22/h3-8,13,22H,9-12,14-15H2,1-2H3 IMSUJZPLLYXTGR-UHFFFAOYSA-N 66933 US20250360145, Example 35 Macrophage colony-stimulating factor 1 receptor Homo sapiens 16.1 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66933&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254714 252645246 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95657 COc1ccc2c(Cc3ccc(OCc4cc(C)on4)c(OC)c3)ccnc2c1 InChI=1S/C25H37N3O4/c1-16(2)21(23(30)26-19-12-8-9-13-19)27-22(29)20-14-17-10-6-7-11-18(17)15-28(20)24(31)32-25(3,4)5/h6-7,10-11,16,19-21H,8-9,12-15H2,1-5H3,(H,26,30)(H,27,29) IYRSIBHLZFSZBG-UHFFFAOYSA-N 66934 US20250360145, Example 36 Macrophage colony-stimulating factor 1 receptor Homo sapiens 39.8 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66934&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254715 252645247 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95658 COc1cnc2c(Cc3cnc(OCc4cnn(C)c4)c(OC)c3)ccnc2c1 InChI=1S/C26H30N2O4/c1-3-20-15-25(30)32-23-14-18(2)13-22(26(20)23)31-17-24(29)27-21-9-11-28(12-10-21)16-19-7-5-4-6-8-19/h4-8,13-15,21H,3,9-12,16-17H2,1-2H3,(H,27,29) POFTVZXAWLFISM-UHFFFAOYSA-N 66935 US20250360145, Example 37 Macrophage colony-stimulating factor 1 receptor Homo sapiens 20.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66935&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254716 252645248 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95659 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)cc1 InChI=1S/C19H22N2O6S2/c1-20(14-8-10-29(25,26)12-14)17(22)7-9-21-18(23)16(28-19(21)24)11-13-3-5-15(27-2)6-4-13/h3-6,11,14H,7-10,12H2,1-2H3 HISNUMGDGYSLQC-UHFFFAOYSA-N 66936 US20250360145, Example 38 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66936&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254717 252645249 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95660 COc1cnc2c(Cc3cnc(OCc4ccc(OC)nc4)c(OC)c3)ccnc2c1 InChI=1S/C17H21ClN2O5/c1-5-24-15(22)19-14(21)17(11(3)4,20(19)16(23)25-6-2)12-7-9-13(18)10-8-12/h7-11H,5-6H2,1-4H3 DCJJAVZZIGQNSD-UHFFFAOYSA-N 66938 US20250360145, Example 39 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66938&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254718 252645250 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95661 COc1cnc(COc2ccc(Cc3ccnc4cc(OC)ccc34)cc2OC)nc1 InChI=1S/C20H22N2O3/c1-14-6-10-16(11-7-14)25-13-12-19(23)22-18-5-3-2-4-17(18)20(24)21-15-8-9-15/h2-7,10-11,15H,8-9,12-13H2,1H3,(H,21,24)(H,22,23) OTOWXFKDXVWQKP-UHFFFAOYSA-N 66939 US20250360145, Example 40 Macrophage colony-stimulating factor 1 receptor Homo sapiens 93.7 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66939&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254719 252645251 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95662 COc1cnc2c(Cc3cnc(OCc4cc(F)cnc4OC)c(OC)c3)ccnc2c1 InChI=1S/C19H14N2O4S/c20-26(23,24)14-8-5-12(6-9-14)18-10-7-13(25-18)11-16-15-3-1-2-4-17(15)21-19(16)22/h1-11H,(H,21,22)(H2,20,23,24) GVLJYOXYVQIXNK-UHFFFAOYSA-N 66940 US20250360145, Example 41 Macrophage colony-stimulating factor 1 receptor Homo sapiens 39.9 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66940&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254720 252645252 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95663 COc1cnc2c(Cc3cnc(OCc4cnc(C)s4)c(OC)c3)ccnc2c1 InChI=1S/C20H20FN3O7S/c1-28-15-10-12(11-16(29-2)18(15)30-3)19-23-24-20(31-19)22-17(25)8-9-32(26,27)14-6-4-13(21)5-7-14/h4-7,10-11H,8-9H2,1-3H3,(H,22,24,25) CRUZQXDUNMWFBO-UHFFFAOYSA-N 66941 US20250360145, Example 42 Macrophage colony-stimulating factor 1 receptor Homo sapiens 14.7 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66941&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254721 252645253 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95664 COc1cnc2c(Cc3cnc(OCc4cnn(C(C)C)c4)c(OC)c3)ccnc2c1 InChI=1S/C22H20N4O3S/c1-3-26-21(29)20-19(16-6-4-5-7-17(16)24-20)25-22(26)30-12-18(28)23-15-10-8-14(9-11-15)13(2)27/h4-11,24H,3,12H2,1-2H3,(H,23,28) VJONUUGXFFUDMV-UHFFFAOYSA-N 66942 US20250360145, Example 43 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.80 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66942&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254722 252645254 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95665 COc1cnc2c(Cc3cnc(OCc4cnc(OC)cn4)c(OC)c3)ccnc2c1 InChI=1S/C19H20N4O5S2/c1-21(2)6-3-7-22(18(24)15-4-5-17(29-15)23(25)26)19-20-12-10-13-14(11-16(12)30-19)28-9-8-27-13/h4-5,10-11H,3,6-9H2,1-2H3 NXIUTMSOSWSBTP-UHFFFAOYSA-N 66943 US20250360145, Example 44 Macrophage colony-stimulating factor 1 receptor Homo sapiens 8.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66943&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254723 252645255 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95666 COc1cnc2c(Cc3cnc(OCc4ccc(C(F)(F)F)nc4)c(OC)c3)ccnc2c1 InChI=1S/C22H24FN3O4S2/c23-18-8-4-9-19-21(18)24-22(31-19)26(11-5-10-25-12-14-30-15-13-25)20(27)16-32(28,29)17-6-2-1-3-7-17/h1-4,6-9H,5,10-16H2 JGQCLAJBUMIBAD-UHFFFAOYSA-N 66947 US20250360145, Example 45 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.31 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66947&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254724 252645259 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95667 COc1cnc2c(Cc3cnc(OCc4cc(C)no4)c(OC)c3)ccnc2c1 InChI=1S/C13H8ClNO4/c14-10-4-1-9(2-5-10)3-6-11(16)12-7-8-13(19-12)15(17)18/h1-8H BWHGGLUTDCVLQU-UHFFFAOYSA-N 66949 US20250360145, Example 46 Macrophage colony-stimulating factor 1 receptor Homo sapiens 22.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66949&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968958 252645261 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95668 CCn1cc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)cn1 InChI=1S/C29H27N3O5S/c1-3-31(4-2)11-12-32(29-30-22-16-24-25(17-26(22)38-29)36-14-13-35-24)27(33)21-15-20-19-8-6-5-7-18(19)9-10-23(20)37-28(21)34/h5-10,15-17H,3-4,11-14H2,1-2H3 IXBPSLWKPGVLHP-UHFFFAOYSA-N 66951 US20250360145, Example 47 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66951&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254725 252645263 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95669 COc1cnc2c(Cc3cnc(OCc4ccn(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C24H24N4O4/c1-16(29)26-18-8-10-19(11-9-18)27-24(31)23(30)25-15-21(22-7-4-14-32-22)28-13-12-17-5-2-3-6-20(17)28/h2-11,14,21H,12-13,15H2,1H3,(H,25,30)(H,26,29)(H,27,31) GRPSYXGLXQDTDB-UHFFFAOYSA-N 66952 US20250360145, Example 48 Macrophage colony-stimulating factor 1 receptor Homo sapiens 8.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66952&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254726 252645264 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95670 COc1cnc2c(Cc3cnc(OCc4ccnn4C)c(OC)c3)ccnc2c1 InChI=1S/C18H18N2O4S/c1-2-19(14-8-4-3-5-9-14)17(21)12-13-20-18(22)15-10-6-7-11-16(15)25(20,23)24/h3-11H,2,12-13H2,1H3 DSFNLCDEJCYMDD-UHFFFAOYSA-N 66954 US20250360145, Example 49 Macrophage colony-stimulating factor 1 receptor Homo sapiens 62.1 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66954&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254727 252645266 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95671 COc1cnc2c(Cc3cnc(OCc4cnc(OC)nc4)c(OC)c3)ccnc2c1 InChI=1S/C23H25F3N2O3/c1-14-10-16(3)19(11-15(14)2)20(29)13-31-22(30)17-6-8-28(9-7-17)21-5-4-18(12-27-21)23(24,25)26/h4-5,10-12,17H,6-9,13H2,1-3H3 WMQDFWWSSZUBQY-UHFFFAOYSA-N 66955 US20250360145, Example 50 Macrophage colony-stimulating factor 1 receptor Homo sapiens 15.2 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66955&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254728 252645267 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95672 COc1cnc2c(Cc3cnc(OCc4cc(C)on4)c(OC)c3)ccnc2c1 InChI=1S/C21H19ClFN3O2S/c1-13-24-21(14-7-9-15(23)10-8-14)18(29-13)11-20(28)26(2)12-19(27)25-17-6-4-3-5-16(17)22/h3-10H,11-12H2,1-2H3,(H,25,27) ZEJDGPFCFJVVHD-UHFFFAOYSA-N 66956 US20250360145, Example 51 Macrophage colony-stimulating factor 1 receptor Homo sapiens 105 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66956&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254729 252645268 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95673 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)ncc34)cc2OC)nc1 InChI=1S/C21H22BrNO3/c1-14-7-8-19(18(22)13-14)26-21(25)16-9-11-23(12-10-16)20(24)17-6-4-3-5-15(17)2/h3-8,13,16H,9-12H2,1-2H3 RGMHCRFTHCKLRB-UHFFFAOYSA-N 66957 US20250360145, Example 52 Macrophage colony-stimulating factor 1 receptor Homo sapiens 49.7 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66957&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254730 252645269 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95674 COc1ccc(COc2ncc(Cc3ccnc4ccc(OC)nc34)cc2OC)nc1 InChI=1S/C29H34N4O5/c1-2-37-23-13-15-24(16-14-23)38-20-25(34)32(18-17-21-9-5-3-6-10-21)26-27(30)33(29(36)31-28(26)35)19-22-11-7-4-8-12-22/h4,7-9,11-16H,2-3,5-6,10,17-20,30H2,1H3,(H,31,35,36) RKIXTKNTYJIKLL-UHFFFAOYSA-N 66958 US20250360145, Example 53 Macrophage colony-stimulating factor 1 receptor Homo sapiens 60.1 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66958&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254731 252645270 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95675 COc1ccc(COc2ncc(Oc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C20H18N2O7/c1-27-12-7-8-15(17(9-12)28-2)16(23)11-29-18(24)10-22-20(26)14-6-4-3-5-13(14)19(25)21-22/h3-9H,10-11H2,1-2H3,(H,21,25) BUJPNXVKPYMLAG-UHFFFAOYSA-N 66959 US20250360145, Example 54 Macrophage colony-stimulating factor 1 receptor Homo sapiens 87.1 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66959&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887921 252645271 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95676 COc1cnc2c(Cc3cnc(OCc4ccc(C)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H24N2O5/c1-20(2,3)22(13-15-8-5-4-6-9-15)17(23)14-27-18(24)12-21-19(25)16-10-7-11-26-16/h4-11H,12-14H2,1-3H3,(H,21,25) RZPJXLYSTMZSGK-UHFFFAOYSA-N 66960 US20250360145, Example 55 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66960&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254732 252645272 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95677 COc1cnc2c(Cc3cnc(OCc4ccc(OC(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H20N2O4/c1-12-9-13(2)11-19(10-12)18(21)17-8-7-16(24-17)14-3-5-15(6-4-14)20(22)23/h3-8,12-13H,9-11H2,1-2H3 QTLSKAASRCRKSN-UHFFFAOYSA-N 66961 US20250360145, Example 56 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66961&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254733 252645273 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95678 CCc1cc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)on1 InChI=1S/C20H19N3O3S/c1-15-10-11-19(21-13-15)23-20(24)17-8-5-9-18(12-17)27(25,26)22-14-16-6-3-2-4-7-16/h2-13,22H,14H2,1H3,(H,21,23,24) SVVUVIFXYKUGPK-UHFFFAOYSA-N 66962 US20250360145, Example 57 Macrophage colony-stimulating factor 1 receptor Homo sapiens 19.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66962&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254734 252645274 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95679 COc1cnc2c(Cc3cnc(OCc4ccc(Cl)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H20BrN3O4/c1-2-28-17-9-7-16(8-10-17)24-12-14(11-18(24)25)20(27)23-22-19(26)13-3-5-15(21)6-4-13/h3-10,14H,2,11-12H2,1H3,(H,22,26)(H,23,27) UGWGSIYIAJNDMV-UHFFFAOYSA-N 66963 US20250360145, Example 58 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66963&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254735 252645275 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95680 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5)cn4)c(OC)c3)ccnc2c1 InChI=1S/C23H21F3N2O3/c1-14-7-8-15(2)18(11-14)27-21(29)13-28(3)22(30)20-10-9-19(31-20)16-5-4-6-17(12-16)23(24,25)26/h4-12H,13H2,1-3H3,(H,27,29) XRCSKUMFSBASQD-UHFFFAOYSA-N 66964 US20250360145, Example 59 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66964&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254736 252645276 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95681 COc1cnc2c(Cc3cnc(OCc4ccc(C(F)F)nc4)c(OC)c3)ccnc2c1 InChI=1S/C21H32N2O4S/c1-20(2)12-17-13-21(3,14-20)15-23(17)28(25,26)18-8-5-7-16(11-18)19(24)22-9-6-10-27-4/h5,7-8,11,17H,6,9-10,12-15H2,1-4H3,(H,22,24) FMEMDTLASPXBPG-UHFFFAOYSA-N 66965 US20250360145, Example 60 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66965&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254737 252645277 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95682 COc1cnc2c(Cc3cnc(OCc4ccc(C(F)(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H24N2O2S/c1-4-12-7-6-8-13(5-2)16(12)19-17(22)14-11-23-18(3)10-9-15(21)20(14)18/h6-8,14H,4-5,9-11H2,1-3H3,(H,19,22) SMIQDZIGQAIRLK-UHFFFAOYSA-N 66967 US20250360145, Example 61 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66967&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254738 252645279 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95683 COc1ccc(COc2ncc(Cc3ccnc4cc(Cl)cnc34)cc2OC)nc1 InChI=1S/C20H21NO7S/c1-14-7-9-15(10-8-14)29(25,26)12-11-19(23)28-13-18(22)21-20(24)16-5-3-4-6-17(16)27-2/h3-10H,11-13H2,1-2H3,(H,21,22,24) FLUZJHHWPPCAIJ-UHFFFAOYSA-N 66968 US20250360145, Example 62 Macrophage colony-stimulating factor 1 receptor Homo sapiens 10.9 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66968&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968971 252645280 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95684 COc1ccc(COc2ncc(Cc3ccnc4cc(C)cnc34)cc2OC)nc1 InChI=1S/C19H19N3O4S2/c1-26-17-5-3-2-4-14(17)6-11-18(23)21-15-7-9-16(10-8-15)28(24,25)22-19-20-12-13-27-19/h2-5,7-10,12-13H,6,11H2,1H3,(H,20,22)(H,21,23) QDZBHKYWFRRSDI-UHFFFAOYSA-N 66969 US20250360145, Example 63 Macrophage colony-stimulating factor 1 receptor Homo sapiens 16.7 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66969&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254739 252645281 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95685 COc1ccc(COc2ncc(Cc3ccnc4cc(F)cnc34)cc2OC)nc1 InChI=1S/C12H13ClO4/c1-16-11-5-3-8(7-9(11)13)10(14)4-6-12(15)17-2/h3,5,7H,4,6H2,1-2H3 GESXDCVYURVJQM-UHFFFAOYSA-N 66970 US20250360145, Example 64 Macrophage colony-stimulating factor 1 receptor Homo sapiens 21.8 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66970&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176311405 252645282 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95686 COc1ccc(COc2ncc(Cc3ccnc4cc(C#N)cnc34)cc2OC)nc1 InChI=1S/C17H19Cl2N3O3S/c1-10-13(11(2)25-21-10)8-26-9-17(24)22(3)7-16(23)20-12-4-5-14(18)15(19)6-12/h4-6H,7-9H2,1-3H3,(H,20,23) SCHQPWPELTVUAM-UHFFFAOYSA-N 66971 US20250360145, Example 65 Macrophage colony-stimulating factor 1 receptor Homo sapiens 26.9 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66971&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968996 252645283 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95687 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C26H38N4O3/c1-4-5-9-19-12-14-21(15-13-19)25(32)29(16-18(2)3)22-23(27)30(26(33)28-24(22)31)17-20-10-7-6-8-11-20/h6-8,10-11,18-19,21H,4-5,9,12-17,27H2,1-3H3,(H,28,31,33) WXCYLYXOCBLNNC-UHFFFAOYSA-N 66972 US20250360145, Example 66 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66972&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254740 252645284 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95688 COc1cnc2c(Cc3cnc(OCc4ccc(=O)n(C)c4)c(OC)c3)ccnc2c1 InChI=1S/C22H26FN3O3S/c23-18-7-9-19(10-8-18)30(28,29)26-15-11-17(12-16-26)22(27)24-20-5-1-2-6-21(20)25-13-3-4-14-25/h1-2,5-10,17H,3-4,11-16H2,(H,24,27) ZZSHMXOHKBOXIN-UHFFFAOYSA-N 66973 US20250360145, Example 67 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.30 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66973&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254741 252645285 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95689 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC(F)F)nc1 InChI=1S/C18H13Cl2N3O4/c19-12-3-1-2-10(17(12)20)4-7-16(25)27-9-15(24)21-11-5-6-13-14(8-11)23-18(26)22-13/h1-8H,9H2,(H,21,24)(H2,22,23,26) XHOQARLPBYPBJL-UHFFFAOYSA-N 66974 US20250360145, Example 68 Macrophage colony-stimulating factor 1 receptor Homo sapiens 99.2 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66974&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968991 252645286 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95690 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5)cn4)c(OC(F)F)c3)ccnc2c1 InChI=1S/C25H26N2O6/c1-5-32-23(29)20-17-12-33-19-11-14(31-4)7-9-16(19)21(17)27-22(28)15-8-6-13(2)10-18(15)26-24(30)25(20,27)3/h6-11,17,20-21H,5,12H2,1-4H3,(H,26,30) SYVYOPSWDAARBQ-UHFFFAOYSA-N 66975 US20250360145, Example 69 Macrophage colony-stimulating factor 1 receptor Homo sapiens 203 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66975&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254742 242053447 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95691 COc1cnc2c(Cc3cnc(OCc4nc(C)no4)c(OC)c3)ccnc2c1 InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29) RLAWWYSOJDYHDC-UHFFFAOYSA-N 66979 US20250360145, Example 70 Macrophage colony-stimulating factor 1 receptor Homo sapiens 272 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66979&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254743 252645290 DB00722 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95692 COCc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C11H16N8O8/c20-2-18-4(6(22)16-10(18)26)14-8(24)12-1-13-9(25)15-5-7(23)17-11(27)19(5)3-21/h4-5,20-21H,1-3H2,(H2,12,14,24)(H2,13,15,25)(H,16,22,26)(H,17,23,27) ZCTXEAQXZGPWFG-UHFFFAOYSA-N 66981 US20250360145, Example 71 Macrophage colony-stimulating factor 1 receptor Homo sapiens 25.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66981&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254744 252645292 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95693 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCC5)c(OC)c3)ccnc2c1 InChI=1S/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19) DDSFKIFGAPZBSR-UHFFFAOYSA-N 66982 US20250360145, Example 72 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66982&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254745 252645293 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95694 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCOC5)c(OC)c3)ccnc2c1 InChI=1S/C17H24N2O3S/c1-13(20)18-15-8-10-16(11-9-15)23(21,22)19-12-4-6-14-5-2-3-7-17(14)19/h8-11,14,17H,2-7,12H2,1H3,(H,18,20) VEOJWDIOGYOBBZ-UHFFFAOYSA-N 66984 US20250360145, Example 73 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.30 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66984&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968999 252645295 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95695 [2H]C([2H])([2H])Oc1cc(Cc2ccnc3cc(OC)cnc23)cnc1OCc1ccc(OC)cn1 InChI=1S/C20H17NO5/c1-12-7-8-13(2)16(9-12)21-18(22)11-25-19(23)15-10-14-5-3-4-6-17(14)26-20(15)24/h3-10H,11H2,1-2H3,(H,21,22) TVLIMDOXMPEQRH-UHFFFAOYSA-N 66985 US20250360145, Example 74 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.30 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66985&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254746 252645296 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95696 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCN(C)C5)c(OC)c3)ccnc2c1 InChI=1S/C18H29N3O3S2/c1-14(2)21(15(3)4)18(22)13-25-17-9-8-16(12-19-17)26(23,24)20-10-6-5-7-11-20/h8-9,12,14-15H,5-7,10-11,13H2,1-4H3 PDFHEIVWZDLOCF-UHFFFAOYSA-N 66986 US20250360145, Example 75 Macrophage colony-stimulating factor 1 receptor Homo sapiens 32.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66986&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254747 252645297 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95697 COc1cnc2c(Cc3cnc(OCc4ccc(C5COC5)cn4)c(OC)c3)ccnc2c1 InChI=1S/C19H24N4OS/c1-12-13(2)16(10-20)18(22-14(12)3)25-15(4)17(24)23-19(11-21)8-6-5-7-9-19/h15H,5-9H2,1-4H3,(H,23,24) QKGQIZXFYQNKMB-UHFFFAOYSA-N 66987 US20250360145, Example 76 Macrophage colony-stimulating factor 1 receptor Homo sapiens 13.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66987&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254748 252645298 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95698 COc1ccc(COc2ncc(C(C)c3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C15H10F2N4O2S/c16-11-2-1-10(7-12(11)17)19-13(22)8-24-15-21-20-14(23-15)9-3-5-18-6-4-9/h1-7H,8H2,(H,19,22) HECLELNRYHDTCV-UHFFFAOYSA-N 66988 US20250360145, Example 77 Macrophage colony-stimulating factor 1 receptor Homo sapiens 101 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66988&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254749 252645299 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95699 [2H]C([2H])([2H])Oc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C20H20F2N2O2/c1-3-24(19(26)12-11-15-9-7-14(2)8-10-15)13-18(25)23-20-16(21)5-4-6-17(20)22/h4-12H,3,13H2,1-2H3,(H,23,25) SUEJESRVIGEHJW-UHFFFAOYSA-N 66989 US20250360145, Example 78 Macrophage colony-stimulating factor 1 receptor Homo sapiens 6.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66989&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254750 252645300 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95700 [2H]C([2H])([2H])Oc1cnc2c(Cc3cnc(OCc4ccc(OC)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H22ClN3O3/c1-4-15-17(12(3)25-21-15)18(24)22(5-2)11-16(23)20-10-13-6-8-14(19)9-7-13/h6-9H,4-5,10-11H2,1-3H3,(H,20,23) BKTCPWZDCPQGHN-UHFFFAOYSA-N 66990 US20250360145, Example 79 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66990&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254751 252645301 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95701 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H25F3N2O3S/c21-20(22,23)17-3-1-2-4-18(17)29(27,28)25-9-7-24(8-10-25)19(26)13-16-12-14-5-6-15(16)11-14/h1-4,14-16H,5-13H2 UFUSJNCXBKQYCU-UHFFFAOYSA-N 66991 US20250360145, Example 80 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66991&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645302 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95702 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C21H25N3O7S/c1-2-30-18-8-4-5-9-19(18)31-16-11-21(25)22-12-14-23(15-13-22)32(28,29)20-10-6-3-7-17(20)24(26)27/h3-10H,2,11-16H2,1H3 RMOZJXHYTBVEFS-UHFFFAOYSA-N 66992 US20250360145, Example 81 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66992&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645303 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95703 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O5S/c1-12(23)20-17-11-14(9-10-18(17)27-2)28(25,26)22-16-6-4-3-5-15(16)19(24)21-13-7-8-13/h3-6,9-11,13,22H,7-8H2,1-2H3,(H,20,23)(H,21,24) BEFVONVQJATKOC-UHFFFAOYSA-N 66993 US20250360145, Example 82 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66993&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254753 252645304 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95704 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)no4)c(OC)c3)ccnc2c1 InChI=1S/C20H17Br2N3O2/c1-13-9-17(21)19(18(22)10-13)27-12-14-4-6-15(7-5-14)20(26)25-24-11-16-3-2-8-23-16/h2-11,23H,12H2,1H3,(H,25,26) OKCDKESLNZVCFU-UHFFFAOYSA-N 66994 US20250360145, Example 83 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66994&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254754 252645305 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95705 COc1ccc(COc2ncc(C(F)c3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C19H27NO4/c1-14(2)24-17-11-9-15(10-12-17)19(22)23-13-18(21)20-16-7-5-3-4-6-8-16/h9-12,14,16H,3-8,13H2,1-2H3,(H,20,21) IWCOTUSRCAXMJX-UHFFFAOYSA-N 66995 US20250360145, Example 84 Macrophage colony-stimulating factor 1 receptor Homo sapiens 28.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66995&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968984 252645306 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95706 COc1cnc2c(Cc3cnc(OCc4ccc(CN(C)C)cn4)c(OC)c3)ccnc2c1 InChI=1S/C21H22N4O5S/c1-15-6-7-16(12-19(15)31(28,29)24-8-10-30-11-9-24)23-20(26)14-25-18-5-3-2-4-17(18)22-13-21(25)27/h2-7,12-13H,8-11,14H2,1H3,(H,23,26) HAVWLOVYALXAHS-UHFFFAOYSA-N 66996 US20250360145, Example 85 Macrophage colony-stimulating factor 1 receptor Homo sapiens 110 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66996&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254755 252645307 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95707 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCCO5)c(OC)c3)ccnc2c1 InChI=1S/C20H19FN2O4/c21-16-7-9-17(10-8-16)22-18(24)13-27-20(26)15-5-3-14(4-6-15)12-23-11-1-2-19(23)25/h3-10H,1-2,11-13H2,(H,22,24) BMTQOJQTCHVQRH-UHFFFAOYSA-N 66997 US20250360145, Example 86 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66997&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254756 252645308 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95708 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)OCCN5C)c(OC)c3)ccnc2c1 InChI=1S/C22H27N3O5S/c1-15-6-4-5-13-25(15)31(28,29)21-14-17(7-12-20(21)30-3)22(27)24-19-10-8-18(9-11-19)23-16(2)26/h7-12,14-15H,4-6,13H2,1-3H3,(H,23,26)(H,24,27) JGEINCVVCAMCGY-UHFFFAOYSA-N 66998 US20250360145, Example 87 Macrophage colony-stimulating factor 1 receptor Homo sapiens 0.830 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66998&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254757 252645309 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95709 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C5COC5)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O4S/c1-14(15-4-6-16(7-5-15)22-11-10-20-13-22)21-27(23,24)19-12-17(25-2)8-9-18(19)26-3/h4-14,21H,1-3H3 JBCIHWMMLFETPZ-UHFFFAOYSA-N 66999 US20250360145, Example 88 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66999&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254758 252645310 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95710 COc1cnc2c(Cc3cnc(OCc4ccc(C5CN(C)C5)cn4)c(OC)c3)ccnc2c1 InChI=1S/C17H20FN3O3/c18-12-6-5-7-13(10-12)19-14(22)11-21-15(23)17(20-16(21)24)8-3-1-2-4-9-17/h5-7,10H,1-4,8-9,11H2,(H,19,22)(H,20,24) CZGBDBAAACVCFU-UHFFFAOYSA-N 67001 US20250360145, Example 89 Macrophage colony-stimulating factor 1 receptor Homo sapiens 286 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67001&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254759 252645312 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95711 COc1cnc2c(Cc3cnc(OCc4cc(C5COC5)no4)c(OC)c3)ccnc2c1 InChI=1S/C12H13BrN2O2/c13-9-3-1-8(2-4-9)12(17)14-7-11(16)15-10-5-6-10/h1-4,10H,5-7H2,(H,14,17)(H,15,16) JTZSTPPBIOZXGZ-UHFFFAOYSA-N 67002 US20250360145, Example 90 Macrophage colony-stimulating factor 1 receptor Homo sapiens 17.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67002&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254760 252645313 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95712 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C5CN(C)C5)n4)c(OC)c3)ccnc2c1 InChI=1S/C43H70N16O7/c1-3-5-10-34-32-58(52-50-34)36(11-6-8-15-44)39(62)54-18-22-56(23-19-54)42-47-41(46-17-27-65-29-31-66-30-28-64-26-4-2)48-43(49-42)57-24-20-55(21-25-57)40(63)37(12-7-9-16-45)59-33-35(51-53-59)13-14-38(60)61/h2,32-33,36-37H,3,5-31,44-45H2,1H3,(H,60,61)(H,46,47,48,49)/p+2 ZPGKYIWWEZCCJI-UHFFFAOYSA-P 67003 US20250360145, Example 91 Macrophage colony-stimulating factor 1 receptor Homo sapiens 40.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67003&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254761 242053448 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95713 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)CCC5OC)c(OC)c3)ccnc2c1 InChI=1S/C24H31N3O3S/c1-19-10-11-22(31(29,30)27-14-6-7-15-27)16-23(19)24(28)25-17-20-8-2-3-9-21(20)18-26-12-4-5-13-26/h2-3,8-11,16H,4-7,12-15,17-18H2,1H3,(H,25,28) PTFIDPVNFKUGMI-UHFFFAOYSA-N 67004 US20250360145, Example 92 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.80 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67004&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254762 252645314 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95714 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C23H23FN4O3S/c24-18-5-4-8-20(15-18)32(30,31)27-13-11-26(12-14-27)23(29)22-16-21(17-9-10-17)25-28(22)19-6-2-1-3-7-19/h1-8,15-17H,9-14H2 DYTFCWLSZFELGG-UHFFFAOYSA-N 67005 US20250360145, Example 93 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67005&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254763 252645315 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95715 COc1cnc2c(Cc3cnc(OCc4cn5c(n4)CN(C)CC5)c(OC)c3)ccnc2c1 InChI=1S/C17H18ClN3O6/c1-9-6-10(18)4-5-12(9)26-8-13(23)27-7-11(22)14-15(19)20(2)17(25)21(3)16(14)24/h4-6H,7-8,19H2,1-3H3 HUYDZCKXKHTYOA-UHFFFAOYSA-N 67006 US20250360145, Example 94 Macrophage colony-stimulating factor 1 receptor Homo sapiens 14.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67006&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254764 252645316 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95716 [2H]C([2H])(c1cnc(OCc2ccc(OC)cn2)c(OC)c1)c1ccnc2cc(OC)cnc12 InChI=1S/C21H24ClN3O5S/c1-30-19-5-3-2-4-18(19)21(27)23-11-10-20(26)24-12-14-25(15-13-24)31(28,29)17-8-6-16(22)7-9-17/h2-9H,10-15H2,1H3,(H,23,27) VZRPHEVSSUPCIS-UHFFFAOYSA-N 67007 US20250360145, Example 95 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67007&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254765 252645317 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95717 COCc1cc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nn1C InChI=1S/C19H20O2/c1-14(15-10-6-5-7-11-15)18(20)21-17-13-9-8-12-16(17)19(2,3)4/h5-13H,1H2,2-4H3 FRAMXRUXDPNDAP-UHFFFAOYSA-N 67008 US20250360145, Example 96 Macrophage colony-stimulating factor 1 receptor Homo sapiens 16.2 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67008&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254766 252645318 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95718 COc1cnc2c(Cc3cnc(OCc4cc(C(F)(F)F)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C21H33NO3/c1-18-10-6-15-19(2)8-5-9-20(3,17(23)25-4)14(19)7-11-21(15,13-18)12-16(18)22-24/h14-15,24H,5-13H2,1-4H3 SIEBAZVBQXPWFH-UHFFFAOYSA-N 67009 US20250360145, Example 97 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67009&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254767 242053449 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95719 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCOC5C)c(OC)c3)ccnc2c1 InChI=1S/C31H20ClF3N4O4S/c32-24-9-7-18(15-23(24)31(33,34)35)19-6-8-21-26(16-19)44(42,43)25-5-1-4-22(27(25)28(21)40)30(41)39-13-11-38(12-14-39)29-20(17-36)3-2-10-37-29/h1-10,15-16H,11-14H2 OSBZGDFAJKVCLW-UHFFFAOYSA-N 67011 US20250360145, Example 98 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67011&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254768 252645320 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95720 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCOC5(C)C)c(OC)c3)ccnc2c1 InChI=1S/C32H26FNO6S/c33-22-12-14-24(27(17-22)40-19-20-6-2-1-3-7-20)21-11-13-25-29(16-21)41(37,38)28-10-4-9-26(30(28)31(25)35)32(36)34-18-23-8-5-15-39-23/h1-4,6-7,9-14,16-17,23H,5,8,15,18-19H2,(H,34,36) YKYKNLZRVTYVBQ-UHFFFAOYSA-N 67012 US20250360145, Example 99 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67012&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254769 252645321 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95721 COc1ccc(COc2ncc(Cc3ccnc4cc(N(C)C)cnc34)cc2OC)nc1 InChI=1S/C37H30FNO8S/c1-45-27-12-14-28(15-13-27)46-22-26(40)20-39-37(42)31-8-5-9-33-35(31)36(41)30-16-10-24(18-34(30)48(33,43)44)29-17-11-25(38)19-32(29)47-21-23-6-3-2-4-7-23/h2-19,26,40H,20-22H2,1H3,(H,39,42) DDVWCRQXQALMIQ-UHFFFAOYSA-N 67013 US20250360145, Example 100 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67013&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887928 252645322 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95722 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CC4CC54)c(OC)c3)ccnc2c1 InChI=1S/C27H25NO7S/c1-33-21-11-9-16(13-22(21)34-2)17-8-10-19-24(14-17)36(31,32)23-7-3-6-20(25(23)26(19)29)27(30)28-15-18-5-4-12-35-18/h3,6-11,13-14,18H,4-5,12,15H2,1-2H3,(H,28,30) LEOCGDXQCOGAPF-UHFFFAOYSA-N 67014 US20250360145, Example 101 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67014&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254770 252645323 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95723 COc1cnc2c(Cc3cnc(OCc4cc(C(C)OC)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C34H24FNO6S/c1-41-25-14-12-24(13-15-25)36-34(38)28-8-5-9-30-32(28)33(37)27-16-10-22(18-31(27)43(30,39)40)26-17-11-23(35)19-29(26)42-20-21-6-3-2-4-7-21/h2-19H,20H2,1H3,(H,36,38) FHEOHOAKCIZCGJ-UHFFFAOYSA-N 67016 US20250360145, Example 102 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67016&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254771 252645325 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95724 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C(C)COC5)c(OC)c3)ccnc2c1 67017 US20250360145, Example 103 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67017&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254772 252645326 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95725 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)CC[C@H]5OC)c(OC)c3)ccnc2c1 InChI=1S/C21H24F2N2O4/c1-29-20(27)19-16(15-4-2-12(22)10-17(15)23)11-13-3-5-18(19)25(13)21(28)24-8-6-14(26)7-9-24/h2,4,10,13-14,18,26H,3,5-9,11H2,1H3 UYEXDWQDMHWJTF-UHFFFAOYSA-N 67018 US20250360145, Example 104 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67018&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254773 252645327 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95726 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)CC[C@H]5OC)c(OC)c3)ccnc2c1 InChI=1S/C30H22F3NO7S/c1-39-23-12-10-18(14-24(23)40-2)19-9-11-21-26(15-19)42(37,38)25-8-4-7-22(27(25)28(21)35)29(36)34-16-17-5-3-6-20(13-17)41-30(31,32)33/h3-15H,16H2,1-2H3,(H,34,36) OWLAVFZCLXNHOO-UHFFFAOYSA-N 67019 US20250360145, Example 105 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67019&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254773 252645328 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95727 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)nn4C)c(OC)c3)ccnc2c1 InChI=1S/C21H17NO2S/c1-16-11-13-18(14-12-16)25(23,24)22-15-20(17-7-3-2-4-8-17)19-9-5-6-10-21(19)22/h2-15H,1H3 USCFLFQFEHGOSL-UHFFFAOYSA-N 67020 US20250360145, Example 106 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67020&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254774 252645329 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95728 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCCOC5)c(OC)c3)ccnc2c1 InChI=1S/C15H19NO3/c1-15(2,3)19-14(18)16-10-11(8-9-17)12-6-4-5-7-13(12)16/h4-7,10,17H,8-9H2,1-3H3 VTFPZEDGWAEVDL-UHFFFAOYSA-N 67021 US20250360145, Example 107 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67021&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254775 252645330 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95729 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CC4(CC4)C5)c(OC)c3)ccnc2c1 InChI=1S/C17H14F3NO2/c1-11-7-3-4-8-12(11)16(2)15(22)21(23-16)14-10-6-5-9-13(14)17(18,19)20/h3-10H,1-2H3 VXHXMOMFUNERDY-UHFFFAOYSA-N 67022 US20250360145, Example 108 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67022&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254776 252645331 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95730 COc1cnc2c(Cc3cnc(OCc4cc(C5CC5)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H19N3O5/c23-18(12-14-3-1-6-17(11-14)22(25)26)20-16-5-2-4-15(13-16)19(24)21-7-9-27-10-8-21/h1-6,11,13H,7-10,12H2,(H,20,23) SBJMMYBOFODSAO-UHFFFAOYSA-N 67023 US20250360145, Example 109 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67023&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254777 252645332 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95731 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](C(F)(F)F)C5)c(OC)c3)ccnc2c1 InChI=1S/C22H31N3O4/c1-22(2,3)29-21(28)25-13-5-6-16(14-25)19(26)23-17-9-7-15(8-10-17)20(27)24(4)18-11-12-18/h7-10,16,18H,5-6,11-14H2,1-4H3,(H,23,26) NJMBEGWSLRZUGH-UHFFFAOYSA-N 67024 US20250360145, Example 110 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67024&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254778 252645333 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95732 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)[C@H]4C[C@H]4C5)c(OC)c3)ccnc2c1 InChI=1S/C24H23N3O4/c1-26(14-13-18-7-3-2-4-8-18)24(29)20-10-6-11-21(17-20)25-23(28)16-19-9-5-12-22(15-19)27(30)31/h2-12,15,17H,13-14,16H2,1H3,(H,25,28) PCJUBXIIOHQWSW-UHFFFAOYSA-N 67025 US20250360145, Example 111 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67025&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254779 252645334 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95733 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](F)C5)c(OC)c3)ccnc2c1 InChI=1S/C20H30N2O2S/c1-15(23)21-17-6-8-18(9-7-17)25-14-13-22-12-11-16(20(2,3)4)5-10-19(22)24/h6-9,16H,5,10-14H2,1-4H3,(H,21,23) SPTOBYMWCCVNAY-UHFFFAOYSA-N 67026 US20250360145, Example 112 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67026&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254780 252645335 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95734 COc1cnc2c(Cc3cnc(OCc4cc(C(C)(C)OC)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C27H36N2O2S/c1-20(30)28-23-11-13-25(14-12-23)32-19-24(18-21-8-6-5-7-9-21)29-17-16-22(27(2,3)4)10-15-26(29)31/h5-9,11-14,22,24H,10,15-19H2,1-4H3,(H,28,30) KUOBJHKTSNZISM-UHFFFAOYSA-N 67027 US20250360145, Example 113 Macrophage colony-stimulating factor 1 receptor Homo sapiens 12.3 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67027&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254781 252645336 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95735 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCO[C@H]5C)c(OC)c3)ccnc2c1 InChI=1S/C32H50O8/c1-19-13-20(2)15-28-27(40-28)12-10-8-9-11-21(3)31(37)39-24(6)16-22(4)29(35)30(36)26(34)17-25(33)18-32(7,38)23(5)14-19/h10-12,14,20,22,24-25,27-30,33,35-36,38H,1,8-9,13,15-18H2,2-7H3 PYXZGBVSQBXPDQ-UHFFFAOYSA-N 67029 US20250360145, Example 114 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67029&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254782 252645337 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95736 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCO[C@H]5C)c(OC)c3)ccnc2c1 InChI=1S/C18H19N3O8S2/c22-21(23)15-3-1-2-4-18(15)31(26,27)20-9-7-19(8-10-20)30(24,25)14-5-6-16-17(13-14)29-12-11-28-16/h1-6,13H,7-12H2 QXQZYSGHLQEFCB-UHFFFAOYSA-N 67030 US20250360145, Example 115 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67030&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254782 252645338 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95737 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCN(C)CC5)cnc34)cc2OC)nc1 InChI=1S/C20H12N6S3/c1-26-20(23-24-25-26)29-19-16-14(9-27-18(16)21-10-22-19)13-7-4-6-12-11-5-2-3-8-15(11)28-17(12)13/h2-10H,1H3 DEVPNNKKGPZYFO-UHFFFAOYSA-N 67031 US20250360145, Example 116 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67031&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254783 252645339 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95738 COc1cnc2c(Cc3cnc(OCc4cccc(C(=O)N(C)C)n4)c(OC)c3)ccnc2c1 InChI=1S/C24H18F3NO2/c1-29-20-12-17-14-28-23(15-7-4-3-5-8-15)22(19(17)13-21(20)30-2)16-9-6-10-18(11-16)24(25,26)27/h3-14H,1-2H3 NOPDHOZGIJMWDL-UHFFFAOYSA-N 67032 US20250360145, Example 117 Macrophage colony-stimulating factor 1 receptor Homo sapiens 21.1 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67032&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254784 252645340 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95739 COc1cnc2c(Cc3cnc(OCc4cccc(N5CCC5)n4)c(OC)c3)ccnc2c1 InChI=1S/C26H21NO7/c1-31-19-10-8-17(9-11-19)25-20(12-7-16-5-4-6-18(13-16)27(29)30)21-14-23(32-2)24(33-3)15-22(21)26(28)34-25/h4-15H,1-3H3 SQDQJJQPARSQQC-UHFFFAOYSA-N 67033 US20250360145, Example 118 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67033&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254785 252645341 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95740 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCOCC5)cnc34)cc2OC)nc1 InChI=1S/C24H30N2O7/c1-4-31-22(28)20-17-13-33-18-8-7-14(30-3)10-16(18)21(17)26-19(27)12-25(23(29)24(20,26)2)11-15-6-5-9-32-15/h7-8,10,15,17,20-21H,4-6,9,11-13H2,1-3H3 GHPJFHVSFNKMSR-UHFFFAOYSA-N 67034 US20250360145, Example 119 Macrophage colony-stimulating factor 1 receptor Homo sapiens 0.730 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67034&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887925 242053451 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95741 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)[C@@H]4C[C@@H]4C5)c(OC)c3)ccnc2c1 InChI=1S/C20H24N2O2/c1-2-13-21-20(24)18(14-16-9-5-3-6-10-16)22-19(23)15-17-11-7-4-8-12-17/h3-12,18H,2,13-15H2,1H3,(H,21,24)(H,22,23) CCLFKESIHCRQOU-UHFFFAOYSA-N 67035 US20250360145, Example 120 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67035&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254786 252645342 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95742 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C18H20FN3O2/c1-2-10-21-17(23)16(12-13-7-3-4-8-14(13)19)22-18(24)15-9-5-6-11-20-15/h3-9,11,16H,2,10,12H2,1H3,(H,21,23)(H,22,24) UFZWBWHQNILYST-UHFFFAOYSA-N 67036 US20250360145, Example 121 Macrophage colony-stimulating factor 1 receptor Homo sapiens 19.9 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67036&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254787 252645343 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95743 COc1cnc2c(Cc3cnc(OCc4ccc5cnn(C)c5n4)c(OC)c3)ccnc2c1 InChI=1S/C19H13N5O3S/c1-10-20-16-11-5-2-3-8-14(11)27-18(16)19(21-10)28-9-15-22-12-6-4-7-13(24(25)26)17(12)23-15/h2-8H,9H2,1H3,(H,22,23) FHZIEBDKFDMIAE-UHFFFAOYSA-N 67037 US20250360145, Example 122 Macrophage colony-stimulating factor 1 receptor Homo sapiens 14.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67037&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254788 252645344 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95744 COc1cnc2c(Cc3cnc(OCc4cccc(N(C)C(C)=O)n4)c(OC)c3)ccnc2c1 InChI=1S/C28H27NO4S/c1-17(2)18-7-5-8-19(15-18)20-13-14-22-25(16-20)34(32,33)24-12-6-11-23(26(24)27(22)30)28(31)29-21-9-3-4-10-21/h5-8,11-17,21H,3-4,9-10H2,1-2H3,(H,29,31) MPHMHKSGQBOWRZ-UHFFFAOYSA-N 67038 US20250360145, Example 123 Macrophage colony-stimulating factor 1 receptor Homo sapiens 52.5 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67038&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254789 252645345 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95745 COc1cnc2c(Cc3cnc(OCc4cccn(C)c4=O)c(OC)c3)ccnc2c1 InChI=1S/C27H22F3NO5S/c28-27(29,30)36-19-12-9-16(10-13-19)17-11-14-20-23(15-17)37(34,35)22-8-4-7-21(24(22)25(20)32)26(33)31-18-5-2-1-3-6-18/h4,7-15,18H,1-3,5-6H2,(H,31,33) KCLJPQZSKLADRO-UHFFFAOYSA-N 67039 US20250360145, Example 124 Macrophage colony-stimulating factor 1 receptor Homo sapiens 320 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67039&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254790 252645346 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95746 COc1cnc2c(Cc3cnc(OCc4cccc(=O)n4C)c(OC)c3)ccnc2c1 InChI=1S/C28H17ClF3NO5S/c29-22-6-2-1-4-18(22)15-33-27(35)21-5-3-7-23-25(21)26(34)20-13-10-17(14-24(20)39(23,36)37)16-8-11-19(12-9-16)38-28(30,31)32/h1-14H,15H2,(H,33,35) DJDOURNTDXYZQW-UHFFFAOYSA-N 67040 US20250360145, Example 125 Macrophage colony-stimulating factor 1 receptor Homo sapiens 522 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67040&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254791 252645347 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95747 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCC(OC)C5)cnc34)cc2OC)nc1 InChI=1S/C27H23NO4S/c29-26-21-16-15-19(14-13-18-7-2-1-3-8-18)17-24(21)33(31,32)23-12-6-11-22(25(23)26)27(30)28-20-9-4-5-10-20/h1-3,6-8,11-17,20H,4-5,9-10H2,(H,28,30) FQUYRGBXXUVLKD-UHFFFAOYSA-N 67041 US20250360145, Example 126 Macrophage colony-stimulating factor 1 receptor Homo sapiens 12.2 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67041&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254792 252645348 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95748 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCC5)cnc34)cc2OC)nc1 InChI=1S/C30H24ClNO4S/c1-18(2)19-8-5-9-20(15-19)21-13-14-23-27(16-21)37(35,36)26-12-6-10-24(28(26)29(23)33)30(34)32-17-22-7-3-4-11-25(22)31/h3-16,18H,17H2,1-2H3,(H,32,34) SYDDVTBVEIWGDH-UHFFFAOYSA-N 67042 US20250360145, Example 127 Macrophage colony-stimulating factor 1 receptor Homo sapiens 22.3 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67042&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254793 252645349 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95749 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@@H](F)C5)c(OC)c3)ccnc2c1 InChI=1S/C20H17F3O2/c1-25-17-8-6-13(7-9-17)14-10-15(12-16(24)11-14)18-4-2-3-5-19(18)20(21,22)23/h2-9,12,14H,10-11H2,1H3 WNSCQIZFBIZGRC-UHFFFAOYSA-N 67043 US20250360145, Example 128 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67043&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254794 252645350 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95750 COc1cnc2c(Cc3cnc(OCc4ccc5nccn5n4)c(OC)c3)ccnc2c1 InChI=1S/C28H17BrF3NO5S/c29-22-6-2-1-4-18(22)15-33-27(35)21-5-3-7-23-25(21)26(34)20-13-10-17(14-24(20)39(23,36)37)16-8-11-19(12-9-16)38-28(30,31)32/h1-14H,15H2,(H,33,35) CDRCVKBHIRWKOR-UHFFFAOYSA-N 67044 US20250360145, Example 129 Macrophage colony-stimulating factor 1 receptor Homo sapiens 42.7 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67044&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254795 252645351 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95751 COc1ccc(COc2ncc(Cc3ccnc4cc(-c5cnn(C)c5)cnc34)cc2OC)nc1 InChI=1S/C30H50O4/c1-25(2)14-19-18-8-9-21-27(5)12-11-22(32)26(3,4)20(27)10-13-28(21,6)29(18,7)16-24(34)30(19,17-31)23(33)15-25/h8,19-24,31-34H,9-17H2,1-7H3 CTNHZEZBBGIUJB-UHFFFAOYSA-N 67045 US20250360145, Example 130 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67045&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254796 252645352 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95752 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CC6CC(C5)O6)cnc34)cc2OC)nc1 InChI=1S/C21H20ClN3O2/c1-25(14-21(27)24-19-11-5-4-10-17(19)22)13-20(26)23-18-12-6-8-15-7-2-3-9-16(15)18/h2-12H,13-14H2,1H3,(H,23,26)(H,24,27) AIRCKNQDAQMBNX-UHFFFAOYSA-N 67046 US20250360145, Example 131 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67046&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254797 252645353 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95753 COc1cnc2c(Cc3cnc(OCc4nc5cccnc5n4C)c(OC)c3)ccnc2c1 InChI=1S/C21H20N4O6/c1-13-10-17(18(25(29)30)11-14(13)2)22-19(26)12-31-21(28)16-8-9-20(27)24(23-16)15-6-4-3-5-7-15/h3-7,10-11H,8-9,12H2,1-2H3,(H,22,26) PHRBMYPKLVAPLP-UHFFFAOYSA-N 67047 US20250360145, Example 132 Macrophage colony-stimulating factor 1 receptor Homo sapiens 879 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67047&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254798 252645354 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 95754 COc1ccc(COc2ncc(Cc3ccnc4cc(C(=O)N(C)C)cnc34)cc2OC)nc1 InChI=1S/C24H29N3O5S/c1-17-7-12-21(33(29,30)26-15-20-6-5-13-32-20)14-22(17)24(28)25-16-23(27(2)3)18-8-10-19(31-4)11-9-18/h5-14,23,26H,15-16H2,1-4H3,(H,25,28) ADNUVTVBWBLJMP-UHFFFAOYSA-N 67048 US20250360145, Example 133 Macrophage colony-stimulating factor 1 receptor Homo sapiens 58.8 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67048&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254799 252645355 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 96164 COc1ccc(COc2ncc(Cc3ccnc4cc(-c5ccn(C)n5)cnc34)cc2OC)nc1 InChI=1S/C22H25N3O5S/c26-21(27)13-12-20(17-8-3-1-4-9-17)23-24-22(28)18-10-7-11-19(16-18)31(29,30)25-14-5-2-6-15-25/h1,3-4,7-11,16H,2,5-6,12-15H2,(H,24,28)(H,26,27) ZOBWWXCAAXOJSD-UHFFFAOYSA-N 67049 US20250360145, Example 134 Macrophage colony-stimulating factor 1 receptor Homo sapiens 6.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67049&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 171714247 252645356 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 96165 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCNCC5)cnc34)cc2OC)nc1 InChI=1S/C13H18N2O2S/c16-12(14-11-6-2-1-3-7-11)10-18-13-8-4-5-9-15(13)17/h4-5,8-9,11H,1-3,6-7,10H2,(H,14,16) GMLXBJTWFNRQAK-UHFFFAOYSA-N 67051 US20250360145, Example 135 Macrophage colony-stimulating factor 1 receptor Homo sapiens 22.4 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67051&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254800 252645358 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 96166 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C29H42O7/c1-17(30)33-16-29-13-9-22-27(5)11-7-10-26(3,4)21(27)8-12-28(22,6)23(29)15-20(36-29)19-14-24(32)35-25(19)34-18(2)31/h14,20-23,25H,7-13,15-16H2,1-6H3 RJZULDNPMPWJSC-UHFFFAOYSA-N 67052 US20250360145, Example 136 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67052&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887927 252645359 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 96167 COc1ccc(COc2ncc(Cc3ccnc4cc(C5CC5)cnc34)cc2OC)nc1 InChI=1S/C29H42O7/c1-17(30)33-16-29-13-9-22-27(5)11-7-10-26(3,4)21(27)8-12-28(22,6)23(29)15-20(36-29)19-14-24(32)35-25(19)34-18(2)31/h14,20-23,25H,7-13,15-16H2,1-6H3 RJZULDNPMPWJSC-UHFFFAOYSA-N 67053 US20250360145, Example 137 Macrophage colony-stimulating factor 1 receptor Homo sapiens 21.9 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67053&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254801 252645360 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115595 COc1ccc(COc2ncc(Cc3ccnc4cc(-c5cnc(C)s5)cnc34)cc2OC)nc1 InChI=1S/C36H48N2O7/c1-6-14-28(22-32(40)37-30(24-39)20-26-16-10-8-11-17-26)34(42)38-31(21-27-18-12-9-13-19-27)25-44-35(43)29(15-7-2)23-33(41)45-36(3,4)5/h6-13,16-19,28-31,39H,1-2,14-15,20-25H2,3-5H3,(H,37,40)(H,38,42) QQUMCRNRBXZTAY-UHFFFAOYSA-N 67054 US20250360145, Example 138 Macrophage colony-stimulating factor 1 receptor Homo sapiens 12.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67054&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887929 252645361 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115596 COc1ccc(COc2ncc(Cc3ccnc4cc(-c5ccccn5)cnc34)cc2OC)nc1 InChI=1S/C12H13NO2/c1-3-6-13-10-5-4-8(2)7-9(10)11(14)12(13)15/h4-5,7H,3,6H2,1-2H3 VFFQBMUPSVPUOR-UHFFFAOYSA-N 67055 US20250360145, Example 139 Macrophage colony-stimulating factor 1 receptor Homo sapiens 11.3 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67055&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254802 252645362 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115597 COc1ccc(COc2ncc(Cc3ccnc4cc(-c5cccnc5)cnc34)cc2OC)nc1 InChI=1S/C16H12ClNO2/c1-10-2-7-14-13(8-10)15(19)16(20)18(14)9-11-3-5-12(17)6-4-11/h2-8H,9H2,1H3 VSQRATQPXJILRW-UHFFFAOYSA-N 67057 US20250360145, Example 140 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67057&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887922 252645364 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115598 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CC(OC)C5)cnc34)cc2OC)nc1 InChI=1S/C26H25NO2S/c1-2-6-21(7-3-1)26-25(23-8-4-5-9-24(23)30-26)20-10-12-22(13-11-20)29-19-16-27-14-17-28-18-15-27/h1-13H,14-19H2 GCSDETSBIAIBBS-UHFFFAOYSA-N 67059 US20250360145, Example 141 Macrophage colony-stimulating factor 1 receptor Homo sapiens 7.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67059&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254803 252645366 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115599 COc1ccc(COc2ncc(Cc3ccnc4cc(-n5cc(C)cn5)cnc34)cc2OC)nc1 InChI=1S/C25H33F3N4O7S/c1-14-11-32(15(2)13-33)24(35)19-10-18(29-22(34)8-9-25(26,27)28)6-7-20(19)38-21(14)12-31(5)40(36,37)23-16(3)30-39-17(23)4/h6-7,10,14-15,21,33H,8-9,11-13H2,1-5H3,(H,29,34) HTHMUEIVNNEIFG-UHFFFAOYSA-N 67061 US20250360145, Example 142 Macrophage colony-stimulating factor 1 receptor Homo sapiens 13.8 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67061&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254804 252645368 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115600 COc1ccc(COc2ncc(Cc3ccnc4cc(-n5ccnc5C)cnc34)cc2OC)nc1 InChI=1S/C27H39N3O5S2/c1-19-15-30(20(2)18-31)27(32)22-11-7-12-23(28-37(33,34)25-13-8-14-36-25)26(22)35-24(19)17-29(3)16-21-9-5-4-6-10-21/h7-8,11-14,19-21,24,28,31H,4-6,9-10,15-18H2,1-3H3 RRUJRRCVAXHNFX-UHFFFAOYSA-N 67062 US20250360145, Example 143 Macrophage colony-stimulating factor 1 receptor Homo sapiens 15.7 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67062&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254805 252645369 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115601 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CC(F)(F)C5)cnc34)cc2OC)nc1 InChI=1S/C28H33ClN4O5S/c1-19-15-33(20(2)18-34)28(35)25-14-23(31-39(36,37)24-7-4-22(29)5-8-24)6-9-26(25)38-27(19)17-32(3)16-21-10-12-30-13-11-21/h4-14,19-20,27,31,34H,15-18H2,1-3H3 RTDBYDGQKCGXQZ-UHFFFAOYSA-N 67063 US20250360145, Example 144 Macrophage colony-stimulating factor 1 receptor Homo sapiens 11.3 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67063&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254806 252645370 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115602 COc1cnc2c(Cc3cnc(OCc4cc5cnccn5n4)c(OC)c3)ccnc2c1 InChI=1S/C36H41N3O5S/c1-26-22-39(27(2)25-40)36(41)21-31-20-32(37-45(42,43)33-12-8-5-9-13-33)18-19-34(31)44-35(26)24-38(3)23-28-14-16-30(17-15-28)29-10-6-4-7-11-29/h4-20,26-27,35,37,40H,21-25H2,1-3H3 QMWRRMYICQUONI-UHFFFAOYSA-N 67064 US20250360145, Example 145 Macrophage colony-stimulating factor 1 receptor Homo sapiens 39.1 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67064&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254807 252645371 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115603 COc1ccc(COc2ncc(Cc3c(F)cnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C29H37N5O8S/c1-17-14-34(18(2)16-35)28(36)24-13-21(30-29(37)31-27-19(3)32-42-20(27)4)7-12-25(24)41-26(17)15-33(5)43(38,39)23-10-8-22(40-6)9-11-23/h7-13,17-18,26,35H,14-16H2,1-6H3,(H2,30,31,37) KAIFSXNQEUFTRX-UHFFFAOYSA-N 67065 US20250360145, Example 146 Macrophage colony-stimulating factor 1 receptor Homo sapiens 208 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67065&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254808 252645372 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115604 COc1cnc2c(Cc3cnc(OCc4ccn5nccc5c4)c(OC)c3)ccnc2c1 InChI=1S/C27H40N6O6S/c1-18-13-33(19(2)16-34)26(35)21-11-8-12-22(30-40(37,38)24-15-31(3)17-28-24)25(21)39-23(18)14-32(4)27(36)29-20-9-6-5-7-10-20/h8,11-12,15,17-20,23,30,34H,5-7,9-10,13-14,16H2,1-4H3,(H,29,36) IKTNJFSBNTVRMI-UHFFFAOYSA-N 67066 US20250360145, Example 147 Macrophage colony-stimulating factor 1 receptor Homo sapiens 7.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67066&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254809 252645373 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115605 COc1cnc2c(Cc3cnc(OCc4ccc5ccnn5c4)c(OC)c3)ccnc2c1 InChI=1S/C28H35N5O6S/c1-18-15-33(20(3)17-34)28(36)22-12-9-13-23(29-27(35)24-14-19(2)30-32(24)5)26(22)39-25(18)16-31(4)40(37,38)21-10-7-6-8-11-21/h6-14,18,20,25,34H,15-17H2,1-5H3,(H,29,35) URKRDHSWJLVIPT-UHFFFAOYSA-N 67067 US20250360145, Example 148 Macrophage colony-stimulating factor 1 receptor Homo sapiens 6.30 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67067&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254810 252645374 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115606 COc1cnc2c(Cc3cnc(OCc4cc5cccnc5[nH]4)c(OC)c3)ccnc2c1 InChI=1S/C23H20N4O3/c1-27(23(30)17-9-11-18(12-10-17)25-21(28)13-14-24)15-22(29)26-20-8-4-6-16-5-2-3-7-19(16)20/h2-12H,13,15H2,1H3,(H,25,28)(H,26,29) MZERHWNOMRFKEX-UHFFFAOYSA-N 67068 US20250360145, Example 149 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67068&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254811 252645375 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115607 COc1cnc2c(Cc3cc(OC)c4nc(N5CCC(OC)CC5)ncc4c3)ccnc2c1 InChI=1S/C24H24ClN3O5S/c1-32-21-9-6-19(7-10-21)27-34(30,31)23-16-20(8-11-22(23)28-12-14-33-15-13-28)26-24(29)17-2-4-18(25)5-3-17/h2-11,16,27H,12-15H2,1H3,(H,26,29) LYBMZQCVMDMKFI-UHFFFAOYSA-N 67069 US20250360145, Example 150 Macrophage colony-stimulating factor 1 receptor Homo sapiens 947 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67069&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254812 252645376 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115608 COc1ccc(COc2ccc(Cc3ccnc4cc(OC)cnc34)cn2)nc1 InChI=1S/C19H29N3O4S/c1-15(2)19(23)20-17-14-16(27(24,25)22-10-12-26-13-11-22)6-7-18(17)21-8-4-3-5-9-21/h6-7,14-15H,3-5,8-13H2,1-2H3,(H,20,23) VFDJYMDBVTXVRB-UHFFFAOYSA-N 67070 US20250360145, Example 151 Macrophage colony-stimulating factor 1 receptor Homo sapiens 22.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67070&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968965 252645377 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115609 COc1cnc2c(Cc3ccc4nc(N5CCC(OC)CC5)ncc4c3)ccnc2c1 InChI=1S/C24H21FN4O6S2/c1-15-16(2)27-35-24(15)29-37(33,34)20-13-9-18(10-14-20)26-23(30)21-5-3-4-6-22(21)28-36(31,32)19-11-7-17(25)8-12-19/h3-14,28-29H,1-2H3,(H,26,30) UIVWNTAOLBKFDO-UHFFFAOYSA-N 67071 US20250360145, Example 152 Macrophage colony-stimulating factor 1 receptor Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67071&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254813 252645378 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115610 COc1cnc2c(Cc3ccc4nc(N5CCC(OC)CC5)cnc4c3)ccnc2c1 InChI=1S/C21H25ClN2O5S/c1-24(30(27,28)20-12-2-15(22)3-13-20)17-6-10-19(11-7-17)29-14-21(26)23-16-4-8-18(25)9-5-16/h2-3,6-7,10-13,16,18,25H,4-5,8-9,14H2,1H3,(H,23,26) GTVIWHFYZOVQJE-UHFFFAOYSA-N 67072 US20250360145, Example 153 Macrophage colony-stimulating factor 1 receptor Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67072&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968961 252645379 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115611 COc1cnc2c(Cc3ccc4nc([C@H]5CC[C@@H](OC)CC5)cnc4c3)ccnc2c1 InChI=1S/C16H15N5O2S/c1-10-8-11(2)21-15(17-10)19-16(20-21)24-9-13(22)18-14(23)12-6-4-3-5-7-12/h3-8H,9H2,1-2H3,(H,18,22,23) FBCSTYKTQQTGBD-UHFFFAOYSA-N 67073 US20250360145, Example 154 Macrophage colony-stimulating factor 1 receptor Homo sapiens 28.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67073&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254814 252645380 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115612 COc1cnc2c(Cc3ccc4nc([C@H]5CC[C@@H](OC)CC5)cnc4c3)ccnc2c1 InChI=1S/C19H22FN3O7S2/c1-12(2)18(23-32(28,29)16-9-4-3-8-15(16)20)19(25)30-11-17(24)22-13-6-5-7-14(10-13)31(21,26)27/h3-10,12,18,23H,11H2,1-2H3,(H,22,24)(H2,21,26,27) VQHXLYZYANMSQB-UHFFFAOYSA-N 67074 US20250360145, Example 155 Macrophage colony-stimulating factor 1 receptor Homo sapiens 258 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67074&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254814 252645381 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115613 COc1cnc2c(Cc3ccc4nc(C5CCOCC5)cn4c3)ccnc2c1 InChI=1S/C16H16N2O6S/c1-18-9-3-4-13(18)15(20)17-14(19)10-24-16(21)11-5-7-12(8-6-11)25(2,22)23/h3-9H,10H2,1-2H3,(H,17,19,20) PUPNGCOZLLITKR-UHFFFAOYSA-N 67075 US20250360145, Example 156 Macrophage colony-stimulating factor 1 receptor Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67075&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254815 252645382 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115614 COc1cnc2c(Cc3ccc4nc(C5CCOCC5)cnc4c3)ccnc2c1 InChI=1S/C17H16Cl2N2O4/c1-24-13-4-2-11(3-5-13)6-7-20-15(22)10-25-17(23)12-8-14(18)16(19)21-9-12/h2-5,8-9H,6-7,10H2,1H3,(H,20,22) VSOOACOIJIZKKX-UHFFFAOYSA-N 67077 US20250360145, Example 157 Macrophage colony-stimulating factor 1 receptor Homo sapiens 543 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67077&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254816 252645384 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115615 COc1cnc2c(Cc3ccn4nc(C5CCOCC5)cc4c3)ccnc2c1 InChI=1S/C15H20N6O3S2/c1-3-7(2)17-13-19-20-15(26-13)25-6-9(22)10-11(16)21(8-4-5-8)14(24)18-12(10)23/h7-8H,3-6,16H2,1-2H3,(H,17,19)(H,18,23,24) WMWXCHLCUCQYJJ-UHFFFAOYSA-N 67078 US20250360145, Example 158 Macrophage colony-stimulating factor 1 receptor Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67078&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968966 252645385 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115616 COc1ccc(COc2ccc(Cc3ccnc4cc(OC)ccc34)cc2OC)cc1 InChI=1S/C24H22N2O6/c1-14-6-8-18(32-14)22(27)20-21(16-7-9-17(30-2)19(11-16)31-3)26(24(29)23(20)28)13-15-5-4-10-25-12-15/h4-12,20-21H,13H2,1-3H3 DNPKYEGYXICBIC-UHFFFAOYSA-N 66880 US20250360145, Example 1 Macrophage colony-stimulating factor 1 receptor Homo sapiens 7.50 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66880&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254678 252645194 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115617 COc1ccc(COc2ccc(Cc3ccnc4cc(OC)ccc34)cc2OC)cc1 InChI=1S/C24H22N2O6/c1-14-6-8-18(32-14)22(27)20-21(16-7-9-17(30-2)19(11-16)31-3)26(24(29)23(20)28)13-15-5-4-10-25-12-15/h4-12,20-21H,13H2,1-3H3 DNPKYEGYXICBIC-UHFFFAOYSA-N 66880 US20250360145, Example 1 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66880&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254678 252645194 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115618 COc1ccc(COc2ccc(Cc3ccnc4cc(OC)ccc34)cc2OC)cc1 InChI=1S/C24H22N2O6/c1-14-6-8-18(32-14)22(27)20-21(16-7-9-17(30-2)19(11-16)31-3)26(24(29)23(20)28)13-15-5-4-10-25-12-15/h4-12,20-21H,13H2,1-3H3 DNPKYEGYXICBIC-UHFFFAOYSA-N 66880 US20250360145, Example 1 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66880&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254678 252645194 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115619 COc1ccc(COc2ccc(Cc3ccnc4cc(OC)ccc34)cc2OC)cc1 InChI=1S/C24H22N2O6/c1-14-6-8-18(32-14)22(27)20-21(16-7-9-17(30-2)19(11-16)31-3)26(24(29)23(20)28)13-15-5-4-10-25-12-15/h4-12,20-21H,13H2,1-3H3 DNPKYEGYXICBIC-UHFFFAOYSA-N 66880 US20250360145, Example 1 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66880&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254678 252645194 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115620 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)ccc34)cc2OC)nc1 InChI=1S/C22H27N3O3S2/c1-16-7-9-18(10-8-16)30(27,28)25-21(12-14-29-2)22(26)23-13-11-17-15-24-20-6-4-3-5-19(17)20/h3-10,15,21,24-25H,11-14H2,1-2H3,(H,23,26) LOKYWESSMYIPST-UHFFFAOYSA-N 66908 US20250360145, Example 13 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.80 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66908&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176311401 252645221 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115621 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)ccc34)cc2OC)nc1 InChI=1S/C22H27N3O3S2/c1-16-7-9-18(10-8-16)30(27,28)25-21(12-14-29-2)22(26)23-13-11-17-15-24-20-6-4-3-5-19(17)20/h3-10,15,21,24-25H,11-14H2,1-2H3,(H,23,26) LOKYWESSMYIPST-UHFFFAOYSA-N 66908 US20250360145, Example 13 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66908&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 176311401 252645221 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115622 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)ccc34)cc2OC)nc1 InChI=1S/C22H27N3O3S2/c1-16-7-9-18(10-8-16)30(27,28)25-21(12-14-29-2)22(26)23-13-11-17-15-24-20-6-4-3-5-19(17)20/h3-10,15,21,24-25H,11-14H2,1-2H3,(H,23,26) LOKYWESSMYIPST-UHFFFAOYSA-N 66908 US20250360145, Example 13 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66908&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 176311401 252645221 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115623 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)ccc34)cc2OC)nc1 InChI=1S/C22H27N3O3S2/c1-16-7-9-18(10-8-16)30(27,28)25-21(12-14-29-2)22(26)23-13-11-17-15-24-20-6-4-3-5-19(17)20/h3-10,15,21,24-25H,11-14H2,1-2H3,(H,23,26) LOKYWESSMYIPST-UHFFFAOYSA-N 66908 US20250360145, Example 13 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66908&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 176311401 252645221 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115624 COc1ccc(COc2ncc(Cc3ccnc4cccnc34)cc2OC)nc1 InChI=1S/C21H27NO5S/c1-11-9-14(15(20(24)25)10-12(11)2)18(23)22-19-17(21(26)27-3)13-7-5-4-6-8-16(13)28-19/h14-15H,4-10H2,1-3H3,(H,22,23)(H,24,25) YYFJXWVWFNDEQO-UHFFFAOYSA-N 66911 US20250360145, Example 15 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.80 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66911&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968972 252645224 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115625 COc1ccc(COc2ncc(Cc3ccnc4cccnc34)cc2OC)nc1 InChI=1S/C21H27NO5S/c1-11-9-14(15(20(24)25)10-12(11)2)18(23)22-19-17(21(26)27-3)13-7-5-4-6-8-16(13)28-19/h14-15H,4-10H2,1-3H3,(H,22,23)(H,24,25) YYFJXWVWFNDEQO-UHFFFAOYSA-N 66911 US20250360145, Example 15 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66911&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 175968972 252645224 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115626 COc1ccc(COc2ncc(Cc3ccnc4cccnc34)cc2OC)nc1 InChI=1S/C21H27NO5S/c1-11-9-14(15(20(24)25)10-12(11)2)18(23)22-19-17(21(26)27-3)13-7-5-4-6-8-16(13)28-19/h14-15H,4-10H2,1-3H3,(H,22,23)(H,24,25) YYFJXWVWFNDEQO-UHFFFAOYSA-N 66911 US20250360145, Example 15 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66911&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 175968972 252645224 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115627 COc1ccc(COc2ncc(Cc3ccnc4cccnc34)cc2OC)nc1 InChI=1S/C21H27NO5S/c1-11-9-14(15(20(24)25)10-12(11)2)18(23)22-19-17(21(26)27-3)13-7-5-4-6-8-16(13)28-19/h14-15H,4-10H2,1-3H3,(H,22,23)(H,24,25) YYFJXWVWFNDEQO-UHFFFAOYSA-N 66911 US20250360145, Example 15 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66911&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 175968972 252645224 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115628 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C22H26N2O2/c25-21(19-13-7-4-8-14-19)23-20(17-18-11-5-3-6-12-18)22(26)24-15-9-1-2-10-16-24/h3-8,11-14,20H,1-2,9-10,15-17H2,(H,23,25) GELXWPLRAJVJNR-UHFFFAOYSA-N 66912 US20250360145, Example 16 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66912&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176311404 252645225 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115629 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C22H26N2O2/c25-21(19-13-7-4-8-14-19)23-20(17-18-11-5-3-6-12-18)22(26)24-15-9-1-2-10-16-24/h3-8,11-14,20H,1-2,9-10,15-17H2,(H,23,25) GELXWPLRAJVJNR-UHFFFAOYSA-N 66912 US20250360145, Example 16 Mast/stem cell growth factor receptor Kit Homo sapiens 881 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66912&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 176311404 252645225 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115630 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C22H26N2O2/c25-21(19-13-7-4-8-14-19)23-20(17-18-11-5-3-6-12-18)22(26)24-15-9-1-2-10-16-24/h3-8,11-14,20H,1-2,9-10,15-17H2,(H,23,25) GELXWPLRAJVJNR-UHFFFAOYSA-N 66912 US20250360145, Example 16 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66912&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 176311404 252645225 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115631 COc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C22H26N2O2/c25-21(19-13-7-4-8-14-19)23-20(17-18-11-5-3-6-12-18)22(26)24-15-9-1-2-10-16-24/h3-8,11-14,20H,1-2,9-10,15-17H2,(H,23,25) GELXWPLRAJVJNR-UHFFFAOYSA-N 66912 US20250360145, Example 16 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66912&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 176311404 252645225 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115632 COc1cnc2c(Cc3cnc(OCc4ccc(C)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H24N2O5/c1-20(2,3)22(13-15-8-5-4-6-9-15)17(23)14-27-18(24)12-21-19(25)16-10-7-11-26-16/h4-11H,12-14H2,1-3H3,(H,21,25) RZPJXLYSTMZSGK-UHFFFAOYSA-N 66960 US20250360145, Example 55 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66960&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254732 252645272 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115633 COc1cnc2c(Cc3cnc(OCc4ccc(C)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H24N2O5/c1-20(2,3)22(13-15-8-5-4-6-9-15)17(23)14-27-18(24)12-21-19(25)16-10-7-11-26-16/h4-11H,12-14H2,1-3H3,(H,21,25) RZPJXLYSTMZSGK-UHFFFAOYSA-N 66960 US20250360145, Example 55 Mast/stem cell growth factor receptor Kit Homo sapiens 785 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66960&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254732 252645272 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115634 COc1cnc2c(Cc3cnc(OCc4ccc(C)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H24N2O5/c1-20(2,3)22(13-15-8-5-4-6-9-15)17(23)14-27-18(24)12-21-19(25)16-10-7-11-26-16/h4-11H,12-14H2,1-3H3,(H,21,25) RZPJXLYSTMZSGK-UHFFFAOYSA-N 66960 US20250360145, Example 55 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66960&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254732 252645272 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115635 COc1cnc2c(Cc3cnc(OCc4ccc(C)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H24N2O5/c1-20(2,3)22(13-15-8-5-4-6-9-15)17(23)14-27-18(24)12-21-19(25)16-10-7-11-26-16/h4-11H,12-14H2,1-3H3,(H,21,25) RZPJXLYSTMZSGK-UHFFFAOYSA-N 66960 US20250360145, Example 55 Platelet-derived growth factor receptor beta Homo sapiens 322 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66960&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254732 252645272 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115636 COc1cnc2c(Cc3cnc(OCc4ccc(OC(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H20N2O4/c1-12-9-13(2)11-19(10-12)18(21)17-8-7-16(24-17)14-3-5-15(6-4-14)20(22)23/h3-8,12-13H,9-11H2,1-2H3 QTLSKAASRCRKSN-UHFFFAOYSA-N 66961 US20250360145, Example 56 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66961&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254733 252645273 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115637 COc1cnc2c(Cc3cnc(OCc4ccc(OC(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H20N2O4/c1-12-9-13(2)11-19(10-12)18(21)17-8-7-16(24-17)14-3-5-15(6-4-14)20(22)23/h3-8,12-13H,9-11H2,1-2H3 QTLSKAASRCRKSN-UHFFFAOYSA-N 66961 US20250360145, Example 56 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66961&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254733 252645273 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115638 COc1cnc2c(Cc3cnc(OCc4ccc(OC(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H20N2O4/c1-12-9-13(2)11-19(10-12)18(21)17-8-7-16(24-17)14-3-5-15(6-4-14)20(22)23/h3-8,12-13H,9-11H2,1-2H3 QTLSKAASRCRKSN-UHFFFAOYSA-N 66961 US20250360145, Example 56 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66961&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254733 252645273 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115639 COc1cnc2c(Cc3cnc(OCc4ccc(OC(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H20N2O4/c1-12-9-13(2)11-19(10-12)18(21)17-8-7-16(24-17)14-3-5-15(6-4-14)20(22)23/h3-8,12-13H,9-11H2,1-2H3 QTLSKAASRCRKSN-UHFFFAOYSA-N 66961 US20250360145, Example 56 Platelet-derived growth factor receptor beta Homo sapiens 312 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66961&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254733 252645273 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115640 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5)cn4)c(OC)c3)ccnc2c1 InChI=1S/C23H21F3N2O3/c1-14-7-8-15(2)18(11-14)27-21(29)13-28(3)22(30)20-10-9-19(31-20)16-5-4-6-17(12-16)23(24,25)26/h4-12H,13H2,1-3H3,(H,27,29) XRCSKUMFSBASQD-UHFFFAOYSA-N 66964 US20250360145, Example 59 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.40 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66964&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254736 252645276 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115641 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5)cn4)c(OC)c3)ccnc2c1 InChI=1S/C23H21F3N2O3/c1-14-7-8-15(2)18(11-14)27-21(29)13-28(3)22(30)20-10-9-19(31-20)16-5-4-6-17(12-16)23(24,25)26/h4-12H,13H2,1-3H3,(H,27,29) XRCSKUMFSBASQD-UHFFFAOYSA-N 66964 US20250360145, Example 59 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66964&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254736 252645276 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115642 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5)cn4)c(OC)c3)ccnc2c1 InChI=1S/C23H21F3N2O3/c1-14-7-8-15(2)18(11-14)27-21(29)13-28(3)22(30)20-10-9-19(31-20)16-5-4-6-17(12-16)23(24,25)26/h4-12H,13H2,1-3H3,(H,27,29) XRCSKUMFSBASQD-UHFFFAOYSA-N 66964 US20250360145, Example 59 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66964&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254736 252645276 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115643 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5)cn4)c(OC)c3)ccnc2c1 InChI=1S/C23H21F3N2O3/c1-14-7-8-15(2)18(11-14)27-21(29)13-28(3)22(30)20-10-9-19(31-20)16-5-4-6-17(12-16)23(24,25)26/h4-12H,13H2,1-3H3,(H,27,29) XRCSKUMFSBASQD-UHFFFAOYSA-N 66964 US20250360145, Example 59 Platelet-derived growth factor receptor beta Homo sapiens 349 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66964&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254736 252645276 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115644 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C26H38N4O3/c1-4-5-9-19-12-14-21(15-13-19)25(32)29(16-18(2)3)22-23(27)30(26(33)28-24(22)31)17-20-10-7-6-8-11-20/h6-8,10-11,18-19,21H,4-5,9,12-17,27H2,1-3H3,(H,28,31,33) WXCYLYXOCBLNNC-UHFFFAOYSA-N 66972 US20250360145, Example 66 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66972&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254740 252645284 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115645 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C26H38N4O3/c1-4-5-9-19-12-14-21(15-13-19)25(32)29(16-18(2)3)22-23(27)30(26(33)28-24(22)31)17-20-10-7-6-8-11-20/h6-8,10-11,18-19,21H,4-5,9,12-17,27H2,1-3H3,(H,28,31,33) WXCYLYXOCBLNNC-UHFFFAOYSA-N 66972 US20250360145, Example 66 Mast/stem cell growth factor receptor Kit Homo sapiens 948 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66972&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254740 252645284 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115646 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C26H38N4O3/c1-4-5-9-19-12-14-21(15-13-19)25(32)29(16-18(2)3)22-23(27)30(26(33)28-24(22)31)17-20-10-7-6-8-11-20/h6-8,10-11,18-19,21H,4-5,9,12-17,27H2,1-3H3,(H,28,31,33) WXCYLYXOCBLNNC-UHFFFAOYSA-N 66972 US20250360145, Example 66 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66972&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254740 252645284 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115647 COc1cnc2c(Cc3cnc(OCc4ccc(C5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C26H38N4O3/c1-4-5-9-19-12-14-21(15-13-19)25(32)29(16-18(2)3)22-23(27)30(26(33)28-24(22)31)17-20-10-7-6-8-11-20/h6-8,10-11,18-19,21H,4-5,9,12-17,27H2,1-3H3,(H,28,31,33) WXCYLYXOCBLNNC-UHFFFAOYSA-N 66972 US20250360145, Example 66 Platelet-derived growth factor receptor beta Homo sapiens 73.6 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66972&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254740 252645284 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115648 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCC5)c(OC)c3)ccnc2c1 InChI=1S/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19) DDSFKIFGAPZBSR-UHFFFAOYSA-N 66982 US20250360145, Example 72 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66982&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254745 252645293 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115649 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCC5)c(OC)c3)ccnc2c1 InChI=1S/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19) DDSFKIFGAPZBSR-UHFFFAOYSA-N 66982 US20250360145, Example 72 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66982&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254745 252645293 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115650 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCC5)c(OC)c3)ccnc2c1 InChI=1S/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19) DDSFKIFGAPZBSR-UHFFFAOYSA-N 66982 US20250360145, Example 72 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66982&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254745 252645293 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115651 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCC5)c(OC)c3)ccnc2c1 InChI=1S/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19) DDSFKIFGAPZBSR-UHFFFAOYSA-N 66982 US20250360145, Example 72 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66982&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254745 252645293 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115652 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCOC5)c(OC)c3)ccnc2c1 InChI=1S/C17H24N2O3S/c1-13(20)18-15-8-10-16(11-9-15)23(21,22)19-12-4-6-14-5-2-3-7-17(14)19/h8-11,14,17H,2-7,12H2,1H3,(H,18,20) VEOJWDIOGYOBBZ-UHFFFAOYSA-N 66984 US20250360145, Example 73 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.30 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66984&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 175968999 252645295 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115653 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCOC5)c(OC)c3)ccnc2c1 InChI=1S/C17H24N2O3S/c1-13(20)18-15-8-10-16(11-9-15)23(21,22)19-12-4-6-14-5-2-3-7-17(14)19/h8-11,14,17H,2-7,12H2,1H3,(H,18,20) VEOJWDIOGYOBBZ-UHFFFAOYSA-N 66984 US20250360145, Example 73 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66984&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 175968999 252645295 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115654 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCOC5)c(OC)c3)ccnc2c1 InChI=1S/C17H24N2O3S/c1-13(20)18-15-8-10-16(11-9-15)23(21,22)19-12-4-6-14-5-2-3-7-17(14)19/h8-11,14,17H,2-7,12H2,1H3,(H,18,20) VEOJWDIOGYOBBZ-UHFFFAOYSA-N 66984 US20250360145, Example 73 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66984&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 175968999 252645295 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115655 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CCOC5)c(OC)c3)ccnc2c1 InChI=1S/C17H24N2O3S/c1-13(20)18-15-8-10-16(11-9-15)23(21,22)19-12-4-6-14-5-2-3-7-17(14)19/h8-11,14,17H,2-7,12H2,1H3,(H,18,20) VEOJWDIOGYOBBZ-UHFFFAOYSA-N 66984 US20250360145, Example 73 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66984&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 175968999 252645295 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115656 [2H]C([2H])([2H])Oc1cc(Cc2ccnc3cc(OC)cnc23)cnc1OCc1ccc(OC)cn1 InChI=1S/C20H17NO5/c1-12-7-8-13(2)16(9-12)21-18(22)11-25-19(23)15-10-14-5-3-4-6-17(14)26-20(15)24/h3-10H,11H2,1-2H3,(H,21,22) TVLIMDOXMPEQRH-UHFFFAOYSA-N 66985 US20250360145, Example 74 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.30 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66985&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254746 252645296 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115657 [2H]C([2H])([2H])Oc1cc(Cc2ccnc3cc(OC)cnc23)cnc1OCc1ccc(OC)cn1 InChI=1S/C20H17NO5/c1-12-7-8-13(2)16(9-12)21-18(22)11-25-19(23)15-10-14-5-3-4-6-17(14)26-20(15)24/h3-10H,11H2,1-2H3,(H,21,22) TVLIMDOXMPEQRH-UHFFFAOYSA-N 66985 US20250360145, Example 74 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66985&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254746 252645296 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115658 [2H]C([2H])([2H])Oc1cc(Cc2ccnc3cc(OC)cnc23)cnc1OCc1ccc(OC)cn1 InChI=1S/C20H17NO5/c1-12-7-8-13(2)16(9-12)21-18(22)11-25-19(23)15-10-14-5-3-4-6-17(14)26-20(15)24/h3-10H,11H2,1-2H3,(H,21,22) TVLIMDOXMPEQRH-UHFFFAOYSA-N 66985 US20250360145, Example 74 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66985&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254746 252645296 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115659 [2H]C([2H])([2H])Oc1cc(Cc2ccnc3cc(OC)cnc23)cnc1OCc1ccc(OC)cn1 InChI=1S/C20H17NO5/c1-12-7-8-13(2)16(9-12)21-18(22)11-25-19(23)15-10-14-5-3-4-6-17(14)26-20(15)24/h3-10H,11H2,1-2H3,(H,21,22) TVLIMDOXMPEQRH-UHFFFAOYSA-N 66985 US20250360145, Example 74 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66985&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254746 252645296 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115660 [2H]C([2H])([2H])Oc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C20H20F2N2O2/c1-3-24(19(26)12-11-15-9-7-14(2)8-10-15)13-18(25)23-20-16(21)5-4-6-17(20)22/h4-12H,3,13H2,1-2H3,(H,23,25) SUEJESRVIGEHJW-UHFFFAOYSA-N 66989 US20250360145, Example 78 Macrophage colony-stimulating factor 1 receptor Homo sapiens 6.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66989&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254750 252645300 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115661 [2H]C([2H])([2H])Oc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C20H20F2N2O2/c1-3-24(19(26)12-11-15-9-7-14(2)8-10-15)13-18(25)23-20-16(21)5-4-6-17(20)22/h4-12H,3,13H2,1-2H3,(H,23,25) SUEJESRVIGEHJW-UHFFFAOYSA-N 66989 US20250360145, Example 78 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66989&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254750 252645300 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115662 [2H]C([2H])([2H])Oc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C20H20F2N2O2/c1-3-24(19(26)12-11-15-9-7-14(2)8-10-15)13-18(25)23-20-16(21)5-4-6-17(20)22/h4-12H,3,13H2,1-2H3,(H,23,25) SUEJESRVIGEHJW-UHFFFAOYSA-N 66989 US20250360145, Example 78 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66989&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254750 252645300 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115663 [2H]C([2H])([2H])Oc1ccc(COc2ncc(Cc3ccnc4cc(OC)cnc34)cc2OC)nc1 InChI=1S/C20H20F2N2O2/c1-3-24(19(26)12-11-15-9-7-14(2)8-10-15)13-18(25)23-20-16(21)5-4-6-17(20)22/h4-12H,3,13H2,1-2H3,(H,23,25) SUEJESRVIGEHJW-UHFFFAOYSA-N 66989 US20250360145, Example 78 Platelet-derived growth factor receptor beta Homo sapiens 947 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66989&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254750 252645300 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115664 [2H]C([2H])([2H])Oc1cnc2c(Cc3cnc(OCc4ccc(OC)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H22ClN3O3/c1-4-15-17(12(3)25-21-15)18(24)22(5-2)11-16(23)20-10-13-6-8-14(19)9-7-13/h6-9H,4-5,10-11H2,1-3H3,(H,20,23) BKTCPWZDCPQGHN-UHFFFAOYSA-N 66990 US20250360145, Example 79 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66990&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254751 252645301 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115665 [2H]C([2H])([2H])Oc1cnc2c(Cc3cnc(OCc4ccc(OC)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H22ClN3O3/c1-4-15-17(12(3)25-21-15)18(24)22(5-2)11-16(23)20-10-13-6-8-14(19)9-7-13/h6-9H,4-5,10-11H2,1-3H3,(H,20,23) BKTCPWZDCPQGHN-UHFFFAOYSA-N 66990 US20250360145, Example 79 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66990&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254751 252645301 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115666 [2H]C([2H])([2H])Oc1cnc2c(Cc3cnc(OCc4ccc(OC)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H22ClN3O3/c1-4-15-17(12(3)25-21-15)18(24)22(5-2)11-16(23)20-10-13-6-8-14(19)9-7-13/h6-9H,4-5,10-11H2,1-3H3,(H,20,23) BKTCPWZDCPQGHN-UHFFFAOYSA-N 66990 US20250360145, Example 79 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66990&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254751 252645301 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115667 [2H]C([2H])([2H])Oc1cnc2c(Cc3cnc(OCc4ccc(OC)cn4)c(OC)c3)ccnc2c1 InChI=1S/C18H22ClN3O3/c1-4-15-17(12(3)25-21-15)18(24)22(5-2)11-16(23)20-10-13-6-8-14(19)9-7-13/h6-9H,4-5,10-11H2,1-3H3,(H,20,23) BKTCPWZDCPQGHN-UHFFFAOYSA-N 66990 US20250360145, Example 79 Platelet-derived growth factor receptor beta Homo sapiens 684 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66990&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254751 252645301 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115668 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H25F3N2O3S/c21-20(22,23)17-3-1-2-4-18(17)29(27,28)25-9-7-24(8-10-25)19(26)13-16-12-14-5-6-15(16)11-14/h1-4,14-16H,5-13H2 UFUSJNCXBKQYCU-UHFFFAOYSA-N 66991 US20250360145, Example 80 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66991&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645302 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115669 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H25F3N2O3S/c21-20(22,23)17-3-1-2-4-18(17)29(27,28)25-9-7-24(8-10-25)19(26)13-16-12-14-5-6-15(16)11-14/h1-4,14-16H,5-13H2 UFUSJNCXBKQYCU-UHFFFAOYSA-N 66991 US20250360145, Example 80 Mast/stem cell growth factor receptor Kit Homo sapiens 214 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66991&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645302 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115670 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H25F3N2O3S/c21-20(22,23)17-3-1-2-4-18(17)29(27,28)25-9-7-24(8-10-25)19(26)13-16-12-14-5-6-15(16)11-14/h1-4,14-16H,5-13H2 UFUSJNCXBKQYCU-UHFFFAOYSA-N 66991 US20250360145, Example 80 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66991&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645302 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115671 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C20H25F3N2O3S/c21-20(22,23)17-3-1-2-4-18(17)29(27,28)25-9-7-24(8-10-25)19(26)13-16-12-14-5-6-15(16)11-14/h1-4,14-16H,5-13H2 UFUSJNCXBKQYCU-UHFFFAOYSA-N 66991 US20250360145, Example 80 Platelet-derived growth factor receptor beta Homo sapiens 49.0 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66991&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645302 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115672 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C21H25N3O7S/c1-2-30-18-8-4-5-9-19(18)31-16-11-21(25)22-12-14-23(15-13-22)32(28,29)20-10-6-3-7-17(20)24(26)27/h3-10H,2,11-16H2,1H3 RMOZJXHYTBVEFS-UHFFFAOYSA-N 66992 US20250360145, Example 81 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66992&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645303 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115673 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C21H25N3O7S/c1-2-30-18-8-4-5-9-19(18)31-16-11-21(25)22-12-14-23(15-13-22)32(28,29)20-10-6-3-7-17(20)24(26)27/h3-10H,2,11-16H2,1H3 RMOZJXHYTBVEFS-UHFFFAOYSA-N 66992 US20250360145, Example 81 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66992&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645303 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115674 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C21H25N3O7S/c1-2-30-18-8-4-5-9-19(18)31-16-11-21(25)22-12-14-23(15-13-22)32(28,29)20-10-6-3-7-17(20)24(26)27/h3-10H,2,11-16H2,1H3 RMOZJXHYTBVEFS-UHFFFAOYSA-N 66992 US20250360145, Example 81 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66992&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645303 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115675 COc1cnc2c(Cc3cnc(OCc4ccc([C@H]5CC5(F)F)cn4)c(OC)c3)ccnc2c1 InChI=1S/C21H25N3O7S/c1-2-30-18-8-4-5-9-19(18)31-16-11-21(25)22-12-14-23(15-13-22)32(28,29)20-10-6-3-7-17(20)24(26)27/h3-10H,2,11-16H2,1H3 RMOZJXHYTBVEFS-UHFFFAOYSA-N 66992 US20250360145, Example 81 Platelet-derived growth factor receptor beta Homo sapiens 371 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66992&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254752 252645303 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115676 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O5S/c1-12(23)20-17-11-14(9-10-18(17)27-2)28(25,26)22-16-6-4-3-5-15(16)19(24)21-13-7-8-13/h3-6,9-11,13,22H,7-8H2,1-2H3,(H,20,23)(H,21,24) BEFVONVQJATKOC-UHFFFAOYSA-N 66993 US20250360145, Example 82 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66993&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254753 252645304 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115677 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O5S/c1-12(23)20-17-11-14(9-10-18(17)27-2)28(25,26)22-16-6-4-3-5-15(16)19(24)21-13-7-8-13/h3-6,9-11,13,22H,7-8H2,1-2H3,(H,20,23)(H,21,24) BEFVONVQJATKOC-UHFFFAOYSA-N 66993 US20250360145, Example 82 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66993&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254753 252645304 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115678 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O5S/c1-12(23)20-17-11-14(9-10-18(17)27-2)28(25,26)22-16-6-4-3-5-15(16)19(24)21-13-7-8-13/h3-6,9-11,13,22H,7-8H2,1-2H3,(H,20,23)(H,21,24) BEFVONVQJATKOC-UHFFFAOYSA-N 66993 US20250360145, Example 82 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66993&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254753 252645304 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115679 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O5S/c1-12(23)20-17-11-14(9-10-18(17)27-2)28(25,26)22-16-6-4-3-5-15(16)19(24)21-13-7-8-13/h3-6,9-11,13,22H,7-8H2,1-2H3,(H,20,23)(H,21,24) BEFVONVQJATKOC-UHFFFAOYSA-N 66993 US20250360145, Example 82 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66993&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254753 252645304 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115680 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)no4)c(OC)c3)ccnc2c1 InChI=1S/C20H17Br2N3O2/c1-13-9-17(21)19(18(22)10-13)27-12-14-4-6-15(7-5-14)20(26)25-24-11-16-3-2-8-23-16/h2-11,23H,12H2,1H3,(H,25,26) OKCDKESLNZVCFU-UHFFFAOYSA-N 66994 US20250360145, Example 83 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66994&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254754 252645305 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115681 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)no4)c(OC)c3)ccnc2c1 InChI=1S/C20H17Br2N3O2/c1-13-9-17(21)19(18(22)10-13)27-12-14-4-6-15(7-5-14)20(26)25-24-11-16-3-2-8-23-16/h2-11,23H,12H2,1H3,(H,25,26) OKCDKESLNZVCFU-UHFFFAOYSA-N 66994 US20250360145, Example 83 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66994&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254754 252645305 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115682 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)no4)c(OC)c3)ccnc2c1 InChI=1S/C20H17Br2N3O2/c1-13-9-17(21)19(18(22)10-13)27-12-14-4-6-15(7-5-14)20(26)25-24-11-16-3-2-8-23-16/h2-11,23H,12H2,1H3,(H,25,26) OKCDKESLNZVCFU-UHFFFAOYSA-N 66994 US20250360145, Example 83 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66994&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254754 252645305 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115683 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)no4)c(OC)c3)ccnc2c1 InChI=1S/C20H17Br2N3O2/c1-13-9-17(21)19(18(22)10-13)27-12-14-4-6-15(7-5-14)20(26)25-24-11-16-3-2-8-23-16/h2-11,23H,12H2,1H3,(H,25,26) OKCDKESLNZVCFU-UHFFFAOYSA-N 66994 US20250360145, Example 83 Platelet-derived growth factor receptor beta Homo sapiens 158 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66994&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254754 252645305 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115684 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)OCCN5C)c(OC)c3)ccnc2c1 InChI=1S/C22H27N3O5S/c1-15-6-4-5-13-25(15)31(28,29)21-14-17(7-12-20(21)30-3)22(27)24-19-10-8-18(9-11-19)23-16(2)26/h7-12,14-15H,4-6,13H2,1-3H3,(H,23,26)(H,24,27) JGEINCVVCAMCGY-UHFFFAOYSA-N 66998 US20250360145, Example 87 Macrophage colony-stimulating factor 1 receptor Homo sapiens 0.830 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66998&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254757 252645309 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115685 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)OCCN5C)c(OC)c3)ccnc2c1 InChI=1S/C22H27N3O5S/c1-15-6-4-5-13-25(15)31(28,29)21-14-17(7-12-20(21)30-3)22(27)24-19-10-8-18(9-11-19)23-16(2)26/h7-12,14-15H,4-6,13H2,1-3H3,(H,23,26)(H,24,27) JGEINCVVCAMCGY-UHFFFAOYSA-N 66998 US20250360145, Example 87 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66998&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254757 252645309 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115686 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)OCCN5C)c(OC)c3)ccnc2c1 InChI=1S/C22H27N3O5S/c1-15-6-4-5-13-25(15)31(28,29)21-14-17(7-12-20(21)30-3)22(27)24-19-10-8-18(9-11-19)23-16(2)26/h7-12,14-15H,4-6,13H2,1-3H3,(H,23,26)(H,24,27) JGEINCVVCAMCGY-UHFFFAOYSA-N 66998 US20250360145, Example 87 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66998&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254757 252645309 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115687 COc1cnc2c(Cc3cnc(OCc4cnc5c(c4)OCCN5C)c(OC)c3)ccnc2c1 InChI=1S/C22H27N3O5S/c1-15-6-4-5-13-25(15)31(28,29)21-14-17(7-12-20(21)30-3)22(27)24-19-10-8-18(9-11-19)23-16(2)26/h7-12,14-15H,4-6,13H2,1-3H3,(H,23,26)(H,24,27) JGEINCVVCAMCGY-UHFFFAOYSA-N 66998 US20250360145, Example 87 Platelet-derived growth factor receptor beta Homo sapiens 208 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66998&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254757 252645309 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115688 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C5COC5)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O4S/c1-14(15-4-6-16(7-5-15)22-11-10-20-13-22)21-27(23,24)19-12-17(25-2)8-9-18(19)26-3/h4-14,21H,1-3H3 JBCIHWMMLFETPZ-UHFFFAOYSA-N 66999 US20250360145, Example 88 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66999&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254758 252645310 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115689 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C5COC5)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O4S/c1-14(15-4-6-16(7-5-15)22-11-10-20-13-22)21-27(23,24)19-12-17(25-2)8-9-18(19)26-3/h4-14,21H,1-3H3 JBCIHWMMLFETPZ-UHFFFAOYSA-N 66999 US20250360145, Example 88 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66999&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254758 252645310 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115690 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C5COC5)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O4S/c1-14(15-4-6-16(7-5-15)22-11-10-20-13-22)21-27(23,24)19-12-17(25-2)8-9-18(19)26-3/h4-14,21H,1-3H3 JBCIHWMMLFETPZ-UHFFFAOYSA-N 66999 US20250360145, Example 88 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66999&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254758 252645310 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115691 COc1cnc2c(Cc3cnc(OCc4cc(C)n(C5COC5)n4)c(OC)c3)ccnc2c1 InChI=1S/C19H21N3O4S/c1-14(15-4-6-16(7-5-15)22-11-10-20-13-22)21-27(23,24)19-12-17(25-2)8-9-18(19)26-3/h4-14,21H,1-3H3 JBCIHWMMLFETPZ-UHFFFAOYSA-N 66999 US20250360145, Example 88 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66999&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254758 252645310 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115692 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C23H23FN4O3S/c24-18-5-4-8-20(15-18)32(30,31)27-13-11-26(12-14-27)23(29)22-16-21(17-9-10-17)25-28(22)19-6-2-1-3-7-19/h1-8,15-17H,9-14H2 DYTFCWLSZFELGG-UHFFFAOYSA-N 67005 US20250360145, Example 93 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67005&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254763 252645315 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115693 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C23H23FN4O3S/c24-18-5-4-8-20(15-18)32(30,31)27-13-11-26(12-14-27)23(29)22-16-21(17-9-10-17)25-28(22)19-6-2-1-3-7-19/h1-8,15-17H,9-14H2 DYTFCWLSZFELGG-UHFFFAOYSA-N 67005 US20250360145, Example 93 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67005&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254763 252645315 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115694 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C23H23FN4O3S/c24-18-5-4-8-20(15-18)32(30,31)27-13-11-26(12-14-27)23(29)22-16-21(17-9-10-17)25-28(22)19-6-2-1-3-7-19/h1-8,15-17H,9-14H2 DYTFCWLSZFELGG-UHFFFAOYSA-N 67005 US20250360145, Example 93 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67005&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254763 252645315 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115695 COc1cnc2c(Cc3cnc(OCc4cc(C(C)C)n(C)n4)c(OC)c3)ccnc2c1 InChI=1S/C23H23FN4O3S/c24-18-5-4-8-20(15-18)32(30,31)27-13-11-26(12-14-27)23(29)22-16-21(17-9-10-17)25-28(22)19-6-2-1-3-7-19/h1-8,15-17H,9-14H2 DYTFCWLSZFELGG-UHFFFAOYSA-N 67005 US20250360145, Example 93 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67005&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254763 252645315 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115696 COc1ccc(COc2ncc(Cc3ccnc4cc(N(C)C)cnc34)cc2OC)nc1 InChI=1S/C37H30FNO8S/c1-45-27-12-14-28(15-13-27)46-22-26(40)20-39-37(42)31-8-5-9-33-35(31)36(41)30-16-10-24(18-34(30)48(33,43)44)29-17-11-25(38)19-32(29)47-21-23-6-3-2-4-7-23/h2-19,26,40H,20-22H2,1H3,(H,39,42) DDVWCRQXQALMIQ-UHFFFAOYSA-N 67013 US20250360145, Example 100 Macrophage colony-stimulating factor 1 receptor Homo sapiens 2.20 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67013&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887928 252645322 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115697 COc1ccc(COc2ncc(Cc3ccnc4cc(N(C)C)cnc34)cc2OC)nc1 InChI=1S/C37H30FNO8S/c1-45-27-12-14-28(15-13-27)46-22-26(40)20-39-37(42)31-8-5-9-33-35(31)36(41)30-16-10-24(18-34(30)48(33,43)44)29-17-11-25(38)19-32(29)47-21-23-6-3-2-4-7-23/h2-19,26,40H,20-22H2,1H3,(H,39,42) DDVWCRQXQALMIQ-UHFFFAOYSA-N 67013 US20250360145, Example 100 Mast/stem cell growth factor receptor Kit Homo sapiens 875 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67013&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 176887928 252645322 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115698 COc1ccc(COc2ncc(Cc3ccnc4cc(N(C)C)cnc34)cc2OC)nc1 InChI=1S/C37H30FNO8S/c1-45-27-12-14-28(15-13-27)46-22-26(40)20-39-37(42)31-8-5-9-33-35(31)36(41)30-16-10-24(18-34(30)48(33,43)44)29-17-11-25(38)19-32(29)47-21-23-6-3-2-4-7-23/h2-19,26,40H,20-22H2,1H3,(H,39,42) DDVWCRQXQALMIQ-UHFFFAOYSA-N 67013 US20250360145, Example 100 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67013&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 176887928 252645322 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115699 COc1ccc(COc2ncc(Cc3ccnc4cc(N(C)C)cnc34)cc2OC)nc1 InChI=1S/C37H30FNO8S/c1-45-27-12-14-28(15-13-27)46-22-26(40)20-39-37(42)31-8-5-9-33-35(31)36(41)30-16-10-24(18-34(30)48(33,43)44)29-17-11-25(38)19-32(29)47-21-23-6-3-2-4-7-23/h2-19,26,40H,20-22H2,1H3,(H,39,42) DDVWCRQXQALMIQ-UHFFFAOYSA-N 67013 US20250360145, Example 100 Platelet-derived growth factor receptor beta Homo sapiens 378 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67013&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 176887928 252645322 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115700 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CC4CC54)c(OC)c3)ccnc2c1 InChI=1S/C27H25NO7S/c1-33-21-11-9-16(13-22(21)34-2)17-8-10-19-24(14-17)36(31,32)23-7-3-6-20(25(23)26(19)29)27(30)28-15-18-5-4-12-35-18/h3,6-11,13-14,18H,4-5,12,15H2,1-2H3,(H,28,30) LEOCGDXQCOGAPF-UHFFFAOYSA-N 67014 US20250360145, Example 101 Macrophage colony-stimulating factor 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67014&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254770 252645323 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115701 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CC4CC54)c(OC)c3)ccnc2c1 InChI=1S/C27H25NO7S/c1-33-21-11-9-16(13-22(21)34-2)17-8-10-19-24(14-17)36(31,32)23-7-3-6-20(25(23)26(19)29)27(30)28-15-18-5-4-12-35-18/h3,6-11,13-14,18H,4-5,12,15H2,1-2H3,(H,28,30) LEOCGDXQCOGAPF-UHFFFAOYSA-N 67014 US20250360145, Example 101 Mast/stem cell growth factor receptor Kit Homo sapiens 715 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67014&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254770 252645323 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115702 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CC4CC54)c(OC)c3)ccnc2c1 InChI=1S/C27H25NO7S/c1-33-21-11-9-16(13-22(21)34-2)17-8-10-19-24(14-17)36(31,32)23-7-3-6-20(25(23)26(19)29)27(30)28-15-18-5-4-12-35-18/h3,6-11,13-14,18H,4-5,12,15H2,1-2H3,(H,28,30) LEOCGDXQCOGAPF-UHFFFAOYSA-N 67014 US20250360145, Example 101 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67014&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254770 252645323 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115703 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)CC4CC54)c(OC)c3)ccnc2c1 InChI=1S/C27H25NO7S/c1-33-21-11-9-16(13-22(21)34-2)17-8-10-19-24(14-17)36(31,32)23-7-3-6-20(25(23)26(19)29)27(30)28-15-18-5-4-12-35-18/h3,6-11,13-14,18H,4-5,12,15H2,1-2H3,(H,28,30) LEOCGDXQCOGAPF-UHFFFAOYSA-N 67014 US20250360145, Example 101 Platelet-derived growth factor receptor beta Homo sapiens 839 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67014&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254770 252645323 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115704 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](F)C5)c(OC)c3)ccnc2c1 InChI=1S/C20H30N2O2S/c1-15(23)21-17-6-8-18(9-7-17)25-14-13-22-12-11-16(20(2,3)4)5-10-19(22)24/h6-9,16H,5,10-14H2,1-4H3,(H,21,23) SPTOBYMWCCVNAY-UHFFFAOYSA-N 67026 US20250360145, Example 112 Macrophage colony-stimulating factor 1 receptor Homo sapiens 4.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67026&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254780 252645335 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115705 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](F)C5)c(OC)c3)ccnc2c1 InChI=1S/C20H30N2O2S/c1-15(23)21-17-6-8-18(9-7-17)25-14-13-22-12-11-16(20(2,3)4)5-10-19(22)24/h6-9,16H,5,10-14H2,1-4H3,(H,21,23) SPTOBYMWCCVNAY-UHFFFAOYSA-N 67026 US20250360145, Example 112 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67026&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254780 252645335 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115706 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](F)C5)c(OC)c3)ccnc2c1 InChI=1S/C20H30N2O2S/c1-15(23)21-17-6-8-18(9-7-17)25-14-13-22-12-11-16(20(2,3)4)5-10-19(22)24/h6-9,16H,5,10-14H2,1-4H3,(H,21,23) SPTOBYMWCCVNAY-UHFFFAOYSA-N 67026 US20250360145, Example 112 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67026&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254780 252645335 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115707 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](F)C5)c(OC)c3)ccnc2c1 InChI=1S/C20H30N2O2S/c1-15(23)21-17-6-8-18(9-7-17)25-14-13-22-12-11-16(20(2,3)4)5-10-19(22)24/h6-9,16H,5,10-14H2,1-4H3,(H,21,23) SPTOBYMWCCVNAY-UHFFFAOYSA-N 67026 US20250360145, Example 112 Platelet-derived growth factor receptor beta Homo sapiens 874 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67026&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254780 252645335 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115708 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCN(C)CC5)cnc34)cc2OC)nc1 InChI=1S/C20H12N6S3/c1-26-20(23-24-25-26)29-19-16-14(9-27-18(16)21-10-22-19)13-7-4-6-12-11-5-2-3-8-15(11)28-17(12)13/h2-10H,1H3 DEVPNNKKGPZYFO-UHFFFAOYSA-N 67031 US20250360145, Example 116 Macrophage colony-stimulating factor 1 receptor Homo sapiens 3.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67031&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254783 252645339 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115709 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCN(C)CC5)cnc34)cc2OC)nc1 InChI=1S/C20H12N6S3/c1-26-20(23-24-25-26)29-19-16-14(9-27-18(16)21-10-22-19)13-7-4-6-12-11-5-2-3-8-15(11)28-17(12)13/h2-10H,1H3 DEVPNNKKGPZYFO-UHFFFAOYSA-N 67031 US20250360145, Example 116 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67031&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254783 252645339 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115710 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCN(C)CC5)cnc34)cc2OC)nc1 InChI=1S/C20H12N6S3/c1-26-20(23-24-25-26)29-19-16-14(9-27-18(16)21-10-22-19)13-7-4-6-12-11-5-2-3-8-15(11)28-17(12)13/h2-10H,1H3 DEVPNNKKGPZYFO-UHFFFAOYSA-N 67031 US20250360145, Example 116 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67031&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254783 252645339 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115711 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCN(C)CC5)cnc34)cc2OC)nc1 InChI=1S/C20H12N6S3/c1-26-20(23-24-25-26)29-19-16-14(9-27-18(16)21-10-22-19)13-7-4-6-12-11-5-2-3-8-15(11)28-17(12)13/h2-10H,1H3 DEVPNNKKGPZYFO-UHFFFAOYSA-N 67031 US20250360145, Example 116 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67031&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254783 252645339 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115712 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCOCC5)cnc34)cc2OC)nc1 InChI=1S/C24H30N2O7/c1-4-31-22(28)20-17-13-33-18-8-7-14(30-3)10-16(18)21(17)26-19(27)12-25(23(29)24(20,26)2)11-15-6-5-9-32-15/h7-8,10,15,17,20-21H,4-6,9,11-13H2,1-3H3 GHPJFHVSFNKMSR-UHFFFAOYSA-N 67034 US20250360145, Example 119 Macrophage colony-stimulating factor 1 receptor Homo sapiens 0.730 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67034&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887925 242053451 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115713 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCOCC5)cnc34)cc2OC)nc1 InChI=1S/C24H30N2O7/c1-4-31-22(28)20-17-13-33-18-8-7-14(30-3)10-16(18)21(17)26-19(27)12-25(23(29)24(20,26)2)11-15-6-5-9-32-15/h7-8,10,15,17,20-21H,4-6,9,11-13H2,1-3H3 GHPJFHVSFNKMSR-UHFFFAOYSA-N 67034 US20250360145, Example 119 Mast/stem cell growth factor receptor Kit Homo sapiens 681 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67034&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 176887925 242053451 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115714 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCOCC5)cnc34)cc2OC)nc1 InChI=1S/C24H30N2O7/c1-4-31-22(28)20-17-13-33-18-8-7-14(30-3)10-16(18)21(17)26-19(27)12-25(23(29)24(20,26)2)11-15-6-5-9-32-15/h7-8,10,15,17,20-21H,4-6,9,11-13H2,1-3H3 GHPJFHVSFNKMSR-UHFFFAOYSA-N 67034 US20250360145, Example 119 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67034&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 176887925 242053451 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115715 COc1ccc(COc2ncc(Cc3ccnc4cc(N5CCOCC5)cnc34)cc2OC)nc1 InChI=1S/C24H30N2O7/c1-4-31-22(28)20-17-13-33-18-8-7-14(30-3)10-16(18)21(17)26-19(27)12-25(23(29)24(20,26)2)11-15-6-5-9-32-15/h7-8,10,15,17,20-21H,4-6,9,11-13H2,1-3H3 GHPJFHVSFNKMSR-UHFFFAOYSA-N 67034 US20250360145, Example 119 Platelet-derived growth factor receptor beta Homo sapiens 43.2 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67034&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 176887925 242053451 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115716 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C18H20FN3O2/c1-2-10-21-17(23)16(12-13-7-3-4-8-14(13)19)22-18(24)15-9-5-6-11-20-15/h3-9,11,16H,2,10,12H2,1H3,(H,21,23)(H,22,24) UFZWBWHQNILYST-UHFFFAOYSA-N 67036 US20250360145, Example 121 Macrophage colony-stimulating factor 1 receptor Homo sapiens 19.9 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67036&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 178254787 252645343 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115717 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C18H20FN3O2/c1-2-10-21-17(23)16(12-13-7-3-4-8-14(13)19)22-18(24)15-9-5-6-11-20-15/h3-9,11,16H,2,10,12H2,1H3,(H,21,23)(H,22,24) UFZWBWHQNILYST-UHFFFAOYSA-N 67036 US20250360145, Example 121 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67036&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 178254787 252645343 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115718 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C18H20FN3O2/c1-2-10-21-17(23)16(12-13-7-3-4-8-14(13)19)22-18(24)15-9-5-6-11-20-15/h3-9,11,16H,2,10,12H2,1H3,(H,21,23)(H,22,24) UFZWBWHQNILYST-UHFFFAOYSA-N 67036 US20250360145, Example 121 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67036&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 178254787 252645343 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115719 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C18H20FN3O2/c1-2-10-21-17(23)16(12-13-7-3-4-8-14(13)19)22-18(24)15-9-5-6-11-20-15/h3-9,11,16H,2,10,12H2,1H3,(H,21,23)(H,22,24) UFZWBWHQNILYST-UHFFFAOYSA-N 67036 US20250360145, Example 121 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67036&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 178254787 252645343 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115720 COc1ccc(COc2ncc(Cc3ccnc4cc(-c5ccn(C)n5)cnc34)cc2OC)nc1 InChI=1S/C22H25N3O5S/c26-21(27)13-12-20(17-8-3-1-4-9-17)23-24-22(28)18-10-7-11-19(16-18)31(29,30)25-14-5-2-6-15-25/h1,3-4,7-11,16H,2,5-6,12-15H2,(H,24,28)(H,26,27) ZOBWWXCAAXOJSD-UHFFFAOYSA-N 67049 US20250360145, Example 134 Macrophage colony-stimulating factor 1 receptor Homo sapiens 6.60 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67049&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 171714247 252645356 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115721 COc1ccc(COc2ncc(Cc3ccnc4cc(-c5ccn(C)n5)cnc34)cc2OC)nc1 InChI=1S/C22H25N3O5S/c26-21(27)13-12-20(17-8-3-1-4-9-17)23-24-22(28)18-10-7-11-19(16-18)31(29,30)25-14-5-2-6-15-25/h1,3-4,7-11,16H,2,5-6,12-15H2,(H,24,28)(H,26,27) ZOBWWXCAAXOJSD-UHFFFAOYSA-N 67049 US20250360145, Example 134 Platelet-derived growth factor receptor beta Homo sapiens 394 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67049&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 171714247 252645356 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115722 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C29H42O7/c1-17(30)33-16-29-13-9-22-27(5)11-7-10-26(3,4)21(27)8-12-28(22,6)23(29)15-20(36-29)19-14-24(32)35-25(19)34-18(2)31/h14,20-23,25H,7-13,15-16H2,1-6H3 RJZULDNPMPWJSC-UHFFFAOYSA-N 67052 US20250360145, Example 136 Macrophage colony-stimulating factor 1 receptor Homo sapiens 5.00 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67052&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 176887927 252645359 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115723 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C29H42O7/c1-17(30)33-16-29-13-9-22-27(5)11-7-10-26(3,4)21(27)8-12-28(22,6)23(29)15-20(36-29)19-14-24(32)35-25(19)34-18(2)31/h14,20-23,25H,7-13,15-16H2,1-6H3 RJZULDNPMPWJSC-UHFFFAOYSA-N 67052 US20250360145, Example 136 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67052&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 176887927 252645359 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115724 COc1cnc2c(Cc3cnc(OCc4cc5n(n4)C[C@H](OC)C5)c(OC)c3)ccnc2c1 InChI=1S/C29H42O7/c1-17(30)33-16-29-13-9-22-27(5)11-7-10-26(3,4)21(27)8-12-28(22,6)23(29)15-20(36-29)19-14-24(32)35-25(19)34-18(2)31/h14,20-23,25H,7-13,15-16H2,1-6H3 RJZULDNPMPWJSC-UHFFFAOYSA-N 67052 US20250360145, Example 136 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67052&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 176887927 252645359 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115725 COc1ccc(cc1)COc2ccc(cc2OC)Cc3cnc(nc3N)N InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 cid_11617559::GW-2580::5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::US20250353857, Compound GW-2580::US20250360145, Example GW2580 Macrophage colony-stimulating factor 1 receptor Homo sapiens 7.90 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115726 COc1ccc(cc1)COc2ccc(cc2OC)Cc3cnc(nc3N)N InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 cid_11617559::GW-2580::5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::US20250353857, Compound GW-2580::US20250360145, Example GW2580 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115727 COc1ccc(cc1)COc2ccc(cc2OC)Cc3cnc(nc3N)N InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 cid_11617559::GW-2580::5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::US20250353857, Compound GW-2580::US20250360145, Example GW2580 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115728 COc1ccc(cc1)COc2ccc(cc2OC)Cc3cnc(nc3N)N InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 cid_11617559::GW-2580::5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::US20250353857, Compound GW-2580::US20250360145, Example GW2580 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115729 Cc1cc2c(c[nH]c2nc1)Cc3ccc(nc3F)NCc4cc(cnc4OC)F InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26) NSMOZFXKTHCPTQ-UHFFFAOYSA-N 174948 US9096593, P-2049::US20250353857, Compound PLX5622::US20250360145, Example PLX5622 Macrophage colony-stimulating factor 1 receptor Homo sapiens 9.80 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174948&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 622 6N33 52936034 313043793 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115730 Cc1cc2c(c[nH]c2nc1)Cc3ccc(nc3F)NCc4cc(cnc4OC)F InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26) NSMOZFXKTHCPTQ-UHFFFAOYSA-N 174948 US9096593, P-2049::US20250353857, Compound PLX5622::US20250360145, Example PLX5622 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174948&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 622 6N33 52936034 313043793 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115731 Cc1cc2c(c[nH]c2nc1)Cc3ccc(nc3F)NCc4cc(cnc4OC)F InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26) NSMOZFXKTHCPTQ-UHFFFAOYSA-N 174948 US9096593, P-2049::US20250353857, Compound PLX5622::US20250360145, Example PLX5622 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 562 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174948&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 622 6N33 52936034 313043793 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115732 Cc1cc2c(c[nH]c2nc1)Cc3ccc(nc3F)NCc4cc(cnc4OC)F InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26) NSMOZFXKTHCPTQ-UHFFFAOYSA-N 174948 US9096593, P-2049::US20250353857, Compound PLX5622::US20250360145, Example PLX5622 Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174948&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 622 6N33 52936034 313043793 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115733 CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 |r| InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24) ADZBMFGQQWPHMJ-UHFFFAOYSA-N 50460035 CHEMBL4227505::US20250360145, Example BLZ945 Macrophage colony-stimulating factor 1 receptor Homo sapiens 7.70 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460035&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 46184986 433927300 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115734 CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 |r| InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24) ADZBMFGQQWPHMJ-UHFFFAOYSA-N 50460035 CHEMBL4227505::US20250360145, Example BLZ945 Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460035&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 46184986 433927300 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115735 CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 |r| InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24) ADZBMFGQQWPHMJ-UHFFFAOYSA-N 50460035 CHEMBL4227505::US20250360145, Example BLZ945 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460035&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 46184986 433927300 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115736 CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 |r| InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24) ADZBMFGQQWPHMJ-UHFFFAOYSA-N 50460035 CHEMBL4227505::US20250360145, Example BLZ945 Platelet-derived growth factor receptor beta Homo sapiens 408 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50460035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50460035&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 46184986 433927300 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4 115737 COc1ccc(COc2ncc(Cc3ccnc(-c4cnn(C)c4)n3)cc2OC)nc1 InChI=1S/C19H20F3N3O3S/c20-19(21,22)14-5-3-7-16(11-14)24-18(26)13-23-15-6-4-8-17(12-15)29(27,28)25-9-1-2-10-25/h3-8,11-12,23H,1-2,9-10,13H2,(H,24,26) RNYHOBHVJHIJMF-UHFFFAOYSA-N 67082 US20250360145, Example Comparator A Macrophage colony-stimulating factor 1 receptor Homo sapiens 6.10 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=879&target=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67082&enzyme=Macrophage+colony-stimulating+factor+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 164517046 252645389 1 MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC 4LIQ,6T2W,4DKD Macrophage colony-stimulating factor 1 receptor CSF1R_HUMAN P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7 115738 COc1ccc(COc2ncc(Cc3ccnc(-c4cnn(C)c4)n3)cc2OC)nc1 InChI=1S/C19H20F3N3O3S/c20-19(21,22)14-5-3-7-16(11-14)24-18(26)13-23-15-6-4-8-17(12-15)29(27,28)25-9-1-2-10-25/h3-8,11-12,23H,1-2,9-10,13H2,(H,24,26) RNYHOBHVJHIJMF-UHFFFAOYSA-N 67082 US20250360145, Example Comparator A Mast/stem cell growth factor receptor Kit Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67082&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 164517046 252645389 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,9H71,4U0I,6MOB,1T46,1PKG,6KLA,6ITV,6ITT,1T45,3G0E,3G0F,8S1B,8S1A,8S19,8S18,8S17,8S16,8S15,8S14,8S13,8PQF,8PQE,8PQD,8PQC,8PQB,8PQA,8PQ9,6XVB,6XVA,6XV9,6GQM,6GQL,6GQK,6GQJ Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 115739 COc1ccc(COc2ncc(Cc3ccnc(-c4cnn(C)c4)n3)cc2OC)nc1 InChI=1S/C19H20F3N3O3S/c20-19(21,22)14-5-3-7-16(11-14)24-18(26)13-23-15-6-4-8-17(12-15)29(27,28)25-9-1-2-10-25/h3-8,11-12,23H,1-2,9-10,13H2,(H,24,26) RNYHOBHVJHIJMF-UHFFFAOYSA-N 67082 US20250360145, Example Comparator A Receptor-type tyrosine-protein kinase FLT3 Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67082&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search 164517046 252645389 1 MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF Receptor-type tyrosine-protein kinase FLT3 FLT3_HUMAN P36888 A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414 115740 COc1ccc(COc2ncc(Cc3ccnc(-c4cnn(C)c4)n3)cc2OC)nc1 InChI=1S/C19H20F3N3O3S/c20-19(21,22)14-5-3-7-16(11-14)24-18(26)13-23-15-6-4-8-17(12-15)29(27,28)25-9-1-2-10-25/h3-8,11-12,23H,1-2,9-10,13H2,(H,24,26) RNYHOBHVJHIJMF-UHFFFAOYSA-N 67082 US20250360145, Example Comparator A Platelet-derived growth factor receptor beta Homo sapiens >1000 US Patent 10.7270/Q2KP870Q aid1798643 US20250360145 Wang, H; Zhang, E; Zhao, S; Yang, M; Li, P; Geng, B; Shlevkow, E; Ong, TR; Wang, JY; Lin, Y; Young, MN; Harvey, LM; Chen, YA; Han, X 11/27/2025 4/8/2026 Myrobalan Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=67082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=575&target=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=67082&enzyme=Platelet-derived+growth+factor+receptor+beta&column=ki&startPg=0&Increment=50&submit=Search 164517046 252645389 1 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 3MJG Platelet-derived growth factor receptor beta PGFRB_HUMAN P09619 B5A957 Q8N5L4